| Identification |
|---|
| HMDB Protein ID
| HMDBP08809 |
| Secondary Accession Numbers
| |
| Name
| Solute carrier family 41 member 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SLC41A1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in cation transmembrane transporter activity |
| Specific Function
| Acts as a magnesium transporter that is responsive to magnesium balance |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Function |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| cation transmembrane transporter activity |
| transporter activity |
| Process |
| establishment of localization |
| transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q32.1 |
| SNPs
| SLC41A1 |
| Gene Sequence
|
>1542 bp
ATGTCCTCTAAGCCAGAGCCGAAGGACGTCCACCAACTGAACGGGACTGGCCCTTCTGCC
TCTCCCTGCTCTTCAGATGGCCCAGGGAGAGAGCCCTTGGCTGGGACCTCAGAGTTCCTG
GGGCCTGATGGGGCTGGGGTAGAGGTGGTGATTGAGTCTCGGGCCAACGCCAAGGGGGTT
CGGGAGGAGGACGCCCTGCTGGAGAACGGGAGCCAGAGCAACGAAAGTGACGACGTCAGC
ACAGACCGTGGCCCTGCGCCACCTTCCCCGCTCAAGGAGACCTCCTTTTCCATCGGGCTG
CAAGTACTGTTTCCATTCCTCCTGGCAGGCTTTGGGACCGTGGCTGCTGGCATGGTGTTG
GACATCGTGCAGCACTGGGAAGTCTTCCAGAAGGTGACAGAGGTCTTCATCCTAGTGCCT
GCGCTGCTGGGGCTCAAAGGGAACCTGGAAATGACCCTGGCATCAAGGCTTTCCACTGCA
GCCAACATTGGACACATGGACACACCCAAGGAGCTCTGGCGGATGATCACTGGGAACATG
GCCCTCATCCAGGTGCAGGCCACGGTGGTGGGCTTCCTGGCGTCCATCGCAGCCGTCGTC
TTTGGCTGGATCCCTGATGGCCACTTCAGTATTCCGCACGCCTTCCTGCTCTGTGCTAGC
AGCGTGGCCACAGCCTTCATTGCCTCCCTGGTACTGGGTATGATCATGATTGGAGTCATC
ATTGGCTCTCGCAAGATTGGGATCAACCCAGACAACGTGGCCACACCCATTGCTGCCAGC
CTGGGCGACCTCATCACCTTGGCGCTGCTCTCAGCATCAGCTGGGGGACTCTACCTGGAA
CTGAATCACTGGCGATACATCTACCCACTGGTGTGTGCTTTCTTTGTGGCCCTGCTGCCT
GTCTGGGTGGTGCTGGCCCGACGAAGTCCAGCCACAAGGGAGGTGTTGTACTCGGGCTGG
GAGCCTGTTATCATTGCCATGGCCATCAGCAGTGTGGGAGGCCTCATCTTGGACAAGACT
GTCTCAGACCCCAACTTTGCTGGGATGGCTGTCTTCACGCCTGTGATTAATGGTGTTGGG
GGCAATCTGGTGGCAGTGCAGGCCAGCCGCATCTCCACCTTCCTGCACATGAATGGAATG
CCCGGAGAGAACTCTGAGCAAGCTCCTCGCCGCTGTCCCAGTCCTTGTACCACCTTCTTC
AGCCCTGATGTGAATTCTCGCTCAGCCCGGGTCCTCTTCCTCCTCGCGGTCCCAGGACAC
CTGGTGTTCCTCTACACCATCAGCTGTATGCAGGGCGGGCACACCACCCTCACACTCATC
TTCATCATCTTCTATATGACAGCTGCACTGCTCCAGGTGCTGATTCTCCTGTACATCGCA
GACTGGATGGTGCACTGGATGTGGGGCCGGGGCCTGGACCCGGACAACTTCTCCATCCCA
TACTTGACTGCTCTGGGGGACCTGCTTGGCACTGGGCTCCTAGCACTCAGCTTCCATGTT
CTCTGGCTCATAGGGGACCGAGACACGGATGTCGGGGACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 513 |
| Molecular Weight
| 54900.3 |
| Theoretical pI
| 4.95 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 102-122
- 185-205
- 222-242
- 257-277
- 286-306
- 316-336
- 346-366
- 411-431
- 439-459
- 484-504
|
| Protein Sequence
|
>Solute carrier family 41 member 1
MSSKPEPKDVHQLNGTGPSASPCSSDGPGREPLAGTSEFLGPDGAGVEVVIESRANAKGV
REEDALLENGSQSNESDDVSTDRGPAPPSPLKETSFSIGLQVLFPFLLAGFGTVAAGMVL
DIVQHWEVFQKVTEVFILVPALLGLKGNLEMTLASRLSTAANIGHMDTPKELWRMITGNM
ALIQVQATVVGFLASIAAVVFGWIPDGHFSIPHAFLLCASSVATAFIASLVLGMIMIGVI
IGSRKIGINPDNVATPIAASLGDLITLALLSGISWGLYLELNHWRYIYPLVCAFFVALLP
VWVVLARRSPATREVLYSGWEPVIIAMAISSVGGLILDKTVSDPNFAGMAVFTPVINGVG
GNLVAVQASRISTFLHMNGMPGENSEQAPRRCPSPCTTFFSPDVNSRSARVLFLLVVPGH
LVFLYTISCMQGGHTTLTLIFIIFYMTAALLQVLILLYIADWMVHWMWGRGLDPDNFSIP
YLTALGDLLGTGLLALSFHVLWLIGDRDTDVGD
|
| External Links |
|---|
| GenBank ID Protein
| 27527024 |
| UniProtKB/Swiss-Prot ID
| Q8IVJ1 |
| UniProtKB/Swiss-Prot Entry Name
| S41A1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ514402 |
| GeneCard ID
| SLC41A1 |
| GenAtlas ID
| SLC41A1 |
| HGNC ID
| HGNC:19429 |
| References |
|---|
| General References
| - Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
- Wabakken T, Rian E, Kveine M, Aasheim HC: The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. Biochem Biophys Res Commun. 2003 Jul 4;306(3):718-24. [PubMed:12810078 ]
- Goytain A, Quamme GA: Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters. Physiol Genomics. 2005 May 11;21(3):337-42. Epub 2005 Feb 15. [PubMed:15713785 ]
|
