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Identification
HMDB Protein ID HMDBP08823
Secondary Accession Numbers
  • 14548
Name Dual specificity testis-specific protein kinase 1
Synonyms
  1. Testicular protein kinase 1
Gene Name TESK1
Protein Type Unknown
Biological Properties
General Function Involved in protein kinase activity
Specific Function Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis
Pathways Not Available
Reactions Not Available
GO Classification
Function
protein tyrosine kinase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:9
Locus 9p13
SNPs TESK1
Gene Sequence
>1881 bp
ATGGCCGGGGAACGGCCCCCACTGCGGGGCCCTGGGCCCGGGCCTGGAGAGGTGCCGGGG
GAGGGGCCCCCGGGGCCGGGGGGCACGGGCGGAGGCCCGGGCCGGGGCCGCCCCTCCTCC
TACCGGGCTCTCCGCAGCGCCGTGTCTAGCCTGGCGCGTGTGGACGATTTTCACTGCGCG
GAGAAGATCGGGGCCGGCTTCTTCTCTGAGGTCTACAAGGTTCGGCACCGACAGTCAGGG
CAAGTCATGGTGCTGAAGATGAACAAGCTCCCCAGTAACCGGGGCAACACACTACGGGAA
GTGCAGCTGATGAACCGGCTCAGGCACCCCAACATCCTAAGGTTCATGGGAGTCTGTGTG
CACCAGGGACAGCTGCACGCTCTTACAGAGTATATGAATGGGGGGACATTGGAACAGCTG
CTCAGCTCCCCTGAACCCCTGTCCTGGCCGGTCAGGCTCCACCTGGCCCTGGACATTGCC
CGAGGCCTGCGGTACCTGCACTCCAAAGGTGTATTTCACCGCGACCTCACATCCAAGAAC
TGTCTAGTCCGACGGGAAGATCGAGGCTTCACCGCTGTCGTGGGTGACTTCGGGCTGGCC
GAAAAGATTCCTGTGTATAGGGAGGGGGCAAGGAAGGAGCCATTGGCCGTGGTGGGCTCC
CCATACTGGATGGCTCCAGAGGTGTTACGGGGTGAGCTGTATGATGAGAAGGCTGATGTC
TTTGCCTTCGGGATTGTCCTCTGTGAGCTCATCGCCCGAGTACCTGCAGACCCTGACTAC
CTACCACGCACTGAGGACTTTGGCCTGGATGTGCCTGCTTTCCGAACTCTGGTGGGGGAT
GACTGCCCACTGCCTTTCTTGCTCCTGGCCATCCACTGCTGCAACCTGGAACCCAGCACC
CGTGCCCCCTTCACCGAAATTACCCAGCACCTGGAATGGATCCTGGAGCAGCTGCCTGAG
CCAGCCCCACTCACCAGGACCGCCCTGACACACAATCAGGGCTCTGTTGCAAGAGGGGGT
CCCTCTGCCACGCTTCCCAGGCCAGATCCCCGGCTTTCCCGAAGCCGGTCAGACCTCTTC
CTGCCCCCATCACCAGAATCACCCCCCAACTGGGGGGACAATCTGACTCGAGTCAACCCC
TTCTCACTACGGGAAGACCTCAGGGGTGGCAAGATCAAGCTCTTAGACACACCCAGCAAG
CCAGTCCTGCCTCTTGTGCCACCATCACCATTCCCATCCACTCAGCTGCCCTTGGTGACC
ACTCCGGAGACCCTGGTCCAGCCTGGGACACCTGCCCGCCGCTGCCGCTCACTACCCTCA
TCCCCCGAGCTCCCCCGCCGTATGGAGACAGCACTGCCAGGTCCTGGCCCTCCCGCTGTG
GGCCCCTCGGCTGAAGAGAAGATGGAGTGCGAGGGCAGCAGCCCTGAGCCGGAACCTCCA
GGGCCAGCGCCCCAGCTGCCTCTGGCTGTGGCCACAGACAACTTCATCAGCACCTGTTCC
TCGGCCTCCCAACCCTGGTCCCCTAGATCAGGACCCGTCCTCAATAACAATCCCCCAGCT
GTGGTGGTGAACTCCCCACAAGGCTGGGCTGGGGAGCCCTGGAACCGGGCCCAGCATAGC
CTGCCCCGGGCGGCAGCCCTGGAGCGGACAGAACCCTCGCCACCCCCTTCAGCTCCCCGG
GAGCCCGATGAGGGGCTGCCCTGTCCTGGCTGCTGCCTCGGCCCCTTCAGCTTTGGCTTC
CTGTCCATGTGCCCCCGCCCCACACCAGCTGTTGCCCGCTACCGCAACCTGAACTGTGAG
GCGGGCAGTCTCCTCTGCCACCGAGGGCACCACGCCAAGCCACCCACACCCAGCCTGCAG
CTGCCTGGGGCACGCTCTTAG
Protein Properties
Number of Residues 626
Molecular Weight 67683.7
Theoretical pI 8.15
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Dual specificity testis-specific protein kinase 1
MAGERPPLRGPGPGPGEVPGEGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFHCA
EKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCV
HQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKN
CLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADV
FAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPST
RAPFTEITQHLEWILEQLPEPAPLTRTALTHNQGSVARGGPSATLPRPDPRLSRSRSDLF
LPPSPESPPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPLVPPSPFPSTQLPLVT
TPETLVQPGTPARRCRSLPSSPELPRRMETALPGPGPPAVGPSAEEKMECEGSSPEPEPP
GPAPQLPLAVATDNFISTCSSASQPWSPRSGPVLNNNPPAVVVNSPQGWAGEPWNRAQHS
LPRAAALERTEPSPPPSAPREPDEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCE
AGSLLCHRGHHAKPPTPSLQLPGARS
GenBank ID Protein 55958923
UniProtKB/Swiss-Prot ID Q15569
UniProtKB/Swiss-Prot Entry Name TESK1_HUMAN
PDB IDs Not Available
GenBank Gene ID AL357874
GeneCard ID TESK1
GenAtlas ID TESK1
HGNC ID HGNC:11731
References
General References
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  2. Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H: Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15. [PubMed:19369195 ]
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  4. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  5. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
  6. Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ: Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1. Eur J Biochem. 2002 May;269(10):2546-56. [PubMed:12027893 ]
  7. Toshima J, Ohashi K, Okano I, Nunoue K, Kishioka M, Kuma K, Miyata T, Hirai M, Baba T, Mizuno K: Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells. J Biol Chem. 1995 Dec 29;270(52):31331-7. [PubMed:8537404 ]