Showing Protein Serine/threonine-protein kinase SMG1 (HMDBP08855)
Identification | |||||||
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HMDB Protein ID | HMDBP08855 | ||||||
Secondary Accession Numbers |
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Name | Serine/threonine-protein kinase SMG1 | ||||||
Synonyms |
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Gene Name | SMG1 | ||||||
Protein Type | Unknown | ||||||
Biological Properties | |||||||
General Function | Involved in binding | ||||||
Specific Function | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Acts as part of the SMG1C complex, a mRNA surveillance complex that recognizes and degrades mRNAs containing premature translation termination codons (PTCs). The complex probably acts by associating with ribosomes during tranlation termination on mRNPs. If an exon junction complex (EJC) is located 50-55 or more nucleotides downstream from the termination codon, it phosphorylates UPF1/RENT1, triggering nonsense-mediated decay (NMD). Also acts as a genotoxic stress- activated protein kinase that displays some functional overlap with ATM. Can phosphorylate TP53/p53 and is required for optimal TP53/p53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ | ||||||
Pathways | Not Available | ||||||
Reactions | Not Available | ||||||
GO Classification |
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Cellular Location |
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Gene Properties | |||||||
Chromosome Location | Chromosome:1 | ||||||
Locus | 16p12.3 | ||||||
SNPs | SMG1 | ||||||
Gene Sequence |
>10974 bp ATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCACCAACTATTCGCGGAGC TGGAATGACTGGCAACCCAGAACTGATAGTGCATCAGCTGACCCAGGTAATTTAAAATAT TCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTACGGACTGCAACCTTCAAATTCAGCT GTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAA AAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTG GGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGC AGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGAGAGATCGATGTCTTATTCT GATGAGTCTCGACTGTCGAATCTTCTTCGGAGGATCACCCGGGAAGACGACAGAGACCGA AGATTGGCTACTGTAAAGCAGTTGAAAGAATTTATTCAGCAACCAGAAAATAAGCTGGTA CTAGTTAAACAATTGGATAATATCTTGGCTGCTGTACATGACGTGCTTAATGAAAGTAGC AAATTGCTTCAGGAGTTGAGACAGGAGGGAGCTTGCTGTCTTGGCCTTCTTTGTGCTTCT CTGAGCTATGAGGCTGAGAAGATCTTCAAGTGGATTTTTAGCAAATTTAGCTCATCTGCA AAAGATGAAGTTAAACTCCTCTACTTATGTGCCACCTACAAAGCACTAGAGACTGTAGGA GAAAAGAAAGCCTTTTCATCTGTAATGCAGCTTGTAATGACCAGCCTGCAGTCTATTCTT GAAAATGTGGATACACCAGAATTGCTTTGTAAATGTGTTAAGTGCATTCTTTTGGTGGCT CGATGTTACCCTCATATTTTCAGCACTAATTTTAGGGATACAGTTGATATATTAGTTGGA TGGCATATAGATCATACTCAGAAACCTTCGCTCACGCAGCAGGTATCTGGGTGGTTGCAG AGTTTGGAGCCATTTTGGGTAGCTGATCTTGCATTTTCTACTACTCTTCTTGGTCAGTTT CTGGAAGACATGGAAGCATATGCTGAGGACCTCAGCCATGTGGCCTCTGGGGAATCAGTG GATGAAGATGTCCCTCCTCCATCAGTGTCATTACCAAAGCTGGCTGCACTTCTCCGGGTA TTTAGTACTGTGGTGAGGAGCATTGGGGAACGCTTCAGCCCAATTCGGGGTCCTCCAATT ACTGAGGCATATGTAACAGATGTTCTGTACAGAGTAATGAGATGTGTGACGGCTGCAAAC CAGGTGTTTTTTTCTGAGGCTGTGTTGACAGCTGCTAATGAGTGTGTTGGTGTTTTGCTC GGCAGCTTGGATCCTAGCATGACTATACATTGTGACATGGTCATTACATATGGATTAGAC CAACTGGAGAATTGCCAGACTTGTGGTACCGATTATATCATCTCAGTCTTGAATTTACTC ACGCTGATTGTTGAACAGATAAATACGAAACTGCCATCATCATTTGTAGAAAAACTGTTT ATACCATCATCTAAACTACTATTCTTGCGTTATCATAAAGAAAAAGAGGTTGTTGCTGTA GCCCATGCTGTTTATCAAGCAGTGCTCAGCTTGAAGAATATTCCTGTTTTGGAGACTGCC TATAAGTTAATATTGGGAGAAATGACTTGTGCCCTAAACAACCTCCTACACAGTCTACAA CTTCCTGAGGCCTGTTCTGAAATAAAACATGAGGCTTTTAAGAATCATGTGTTCAATGTA GACAATGCAAAATTTGTAGTTAAATTTGACCTCAGTGCCCTGACTACAATTGGAAATGCC AAAAACTCACTAATAGGGATGTGGGCGCTATCTCCAACTGTCTTTGCACTTCTGAGTAAG AATCTGATGATTGTGCACAGTGACCTGGCTGTTCACTTCCCTGCCATTCAGTATGCTGTG CTCTACACATTGTATTCTCATTGTACCAGGCATGATCACTTTATCTCTAGTAGCCTCAGT TCTGCCTCTCCTTCTTTGTTTGATGGAGCTGTGATTAGCACTGTAACTACGGCTACAAAG AAACATTTCTCAATTATATTAAATCTTCTGGGAATATTACTTAAGAAAGATAACCTTAAC CAGGACACGAGGAAACTGTTAATGACTTGGGCTTTGGAAGCAGCTGTTTTAATGAGGAAG TCTGAAACATACGCACCTTTATTCTCTCTTCCGTCTTTCCATAAATTTTGCAAAGGCCTT TTAGCCAACACTCTCGTTGAAGATGTGAATATCTGTCTGCAGGCATGCAGCAGTCTACAT GCTCTGTCCTCTTCCTTGCCAGATGATCTTTTACAGAGATGTGTCGATGTTTGCCGTGTT CAACTAGTGCACAGTGGAACTCGTATTCGACAAGCATTTGGAAAACTGTTGAAATCAATT CCTTTAGATGTTGTCCTAAGCAATAACAATCACACAGAAATTCAAGAAATTTCTTTAGCA TTAAGAAGTCACATGAGTAAAGCACCAAGTAATACATTCCACCCCCAAGATTTCTCTGAT GTTATTAGTTTTATTTTGTATGGGAACTCTCATAGAACAGGGAAGGACAATTGGTTGGAA AGACTGTTCTATAGCTGCCAGAGACTGGATAAGCGTGACCAGTCAACAATTCCACGCAAT CTCCTGAAGACAGATGCTGTCCTTTGGCAGTGGGCCATATGGGAAGCTGCACAATTCACT GTTCTTTCTAAGCTGAGAACCCCACTGGGCAGAGCTCAAGACACCTTCCAGACAATTGAA GGTATCATTCGAAGTCTCGCAGCTCACACATTAAACCCTGATCAGGATGTTAGTCAGTGG ACAACTGCAGACAATGATGAAGGCCATGGTAACAACCAACTTAGACTTGTTCTTCTTCTG CAGTATCTGGAAAATCTGGAGAAATTAATGTATAATGCATACGAGGGATGTGCTAATGCA TTAACTTCACCTCCCAAGGTCATTAGAACTTTTTTCTATACCAATCGCCAAACTTGTCAG GACTGGCTAACGCGGATTCGACTCTCCATCATGAGGGTAGGATTGTTGGCAGGCCAGCCT GCAGTGACAGTGAGACATGGCTTTGACTTGCTTACAGAGATGAAAACAACCAGCCTATCT CAGGGGAATGAATTGGAAGTAACCATTATGATGGTGGTAGAAGCATTATGTGAACTTCAT TGTCCTGAAGCTATACAGGGAATTGCTGTCTGGTCATCATCTATTGTTGGAAAAAATCTT CTGTGGATTAACTCAGTGGCTCAACAGGCTGAAGGGAGGTTTGAAAAGGCCTCTGTGGAG TACCAGGAACACCTGTGTGCCATGACAGGTGTTGATTGCTGCATCTCCAGCTTTGACAAA TCGGTGCTCACCTTAGCCAATGCTGGGCGTAACAGTGCCAGCCCGAAACATTCTCTGAAT GGTGAATCCAGAAAAACTGTGCTGTCCAAACCGACTGACTCTTCCCCTGAGGTTATAAAT TATTTAGGAAATAAAGCATGTGAGTTCTACATCTCAATTGCCGATTGGGCTGCTGTGCAG GAATGGCAGAACGCTATCCATGACTTGAAAAAGAGTACCAGTAGCACTTCCCTCAACCTG AAAGCTGACTTCAACTATATAAAATCATTAAGCAGCTTTGAGTCTGGAAAATTTGTTGAA TGTACCGAGCAGTTAGAATTGTTACCAGGAGAAAATATCAATCTACTTGCTGGAGGATCA AAAGAAAAAATAGACATGAAAAAACTGCTTCCTAACATGTTAAGTCCGGATCCGAGGGAA CTTCAGAAATCCATTGAAGTTCAATTGTTAAGAAGTTCTGTTTGTTTGGCAACTGCTTTA AACCCGATAGAACAAGATCAGAAGTGGCAGTCTATAACTGAAAATGTGGTAAAGTACTTG AAGCAAACATCCCGCATCGCTATTGGACCTCTGAGACTTTCTACTTTAACAGTTTCACAG TCTTTGCCAGTTCTAAGTACCTTGCAGCTGTATTGCTCATCTGCTTTGGAGAACACAGTT TCTAACAGACTTTCAACAGAGGACTGTCTTATTCCACTCTTCAGTGAAGCTTTACGTTCA TGTAAACAGCATGACGTGAGGCCATGGATGCAGGCATTAAGGTATACTATGTACCAGAAT CAGTTGTTGGAGAAAATTAAAGAACAAACAGTCCCAATTAGAAGCCATCTCATGGAATTA GGTCTAACAGCAGCAAAATTTGCTAGAAAACGAGGGAATGTGTCCCTTGCAACAAGACTG CTGGCACAGTGCAGTGAAGTTCAGCTGGGAAAGACCACCACTGCACAGGATTTAGTCCAA CATTTTAAAAAACTATCAACCCAAGGTCAAGTGGATGAAAAATGGGGGCCCGAACTTGAT ATTGAAAAAACCAAATTGCTTTATACAGCAGGCCAGTCAACACATGCAATGGAAATGTTG AGTTCTTGTGCCATATCTTTCTGCAAGTCTGTGAAAGCTGAATATGCAGTTGCTAAATCA ATTCTGACACTGGCTAAATGGATCCAGGCAGAATGGAAAGAGATTTCAGGACAGCTGAAA CAGGTTTACAGAGCTCAGCACCAACAGAACTTCACAGGTCTTTCTACTTTGTCTAAAAAC ATACTCACTCTAATAGAACTGCCATCTGTTAATACGATGGAAGAAGAGTATCCTCGGATC GAGAGTGAATCTACAGTGCATATTGGAGTTGGAGAACCTGACTTCATTTTGGGACAGTTG TATCACCTGTCTTCAGTACAGGCACCTGAAGTAGCCAAATCTTGGGCAGCGTTGGCCAGC TGGGCTTATAGGTGGGGCAGAAAGGTGGTTGACAATGCCAGTCAGGGAGAAGGTGTTCGT CTGCTGCCTAGAGAAAAATCTGAAGTTCAGAATCTACTTCCAGACACTATAACTGAGGAA GAGAAAGAGAGAATATATGGTATTCTTGGACAGGCTGTGTGTCGGCCGGCGGGGATTCAG GATGAAGATATAACACTTCAGATAACTGAGAGTGAAGACAACGAAGAAGATGACATGGTT GATGTTATCTGGCGTCAGTTGATATCAAGCTGCCCATGGCTTTCAGAACTTGATGAAAGT GCAACTGAAGGAGTTATTAAAGTGTGGAGGAAAGTTGTAGATAGAATATTCAGCCTGTAC AAACTCTCTTGCAGTGCATACTTTACTTTCCTTAAACTCAACGCTGGTCAAATTCCTTTA GATGAGGATGACCCTAGGCTGCATTTAAGTCACAGAGTGGAACAGAGCACTGATGACATG ATTGTGATGGCCACATTGCGCCTGCTGCGGTTGCTCGTGAAGCATGCTGGTGAGCTTCGG CAGTATCTGGAGCACGGCTTGGAGACAACACCCACTGCACCATGGAGGGGAATTATTCCG CAACTTTTCTCACGCTTAAACCACCCTGAAGTGTATGTGCGCCAAAGTATTTGTAACCTT CTCTGCCGTGTGGCTCAAGATTCCCCACATCTCATATTGTATCCTGCAATAGTGGGTACC ATATCGCTTAGTAGTGAATCCCAGGCTTCAGGAAATAAATTTTCCACTGCAATTCCAACT TTACTTGGCAATATTCAAGGAGAAGAATTGCTGGTTTCTGAATGTGAGGGAGGAAGTCCT CCTGCATCTCAGGATAGCAATAAGGATGAACCTAAAAGTGGATTAAATGAAGACCAAGCC ATGATGCAGGATTGTTACAGCAAAATTGTAGATAAGCTGTCCTCTGCAAACCCCACCATG GTATTACAGGTTCAGATGCTCGTGGCTGAACTGCGCAGGGTCACTGTGCTCTGGGATGAG CTCTGGCTGGGAGTTTTGCTGCAACAACACATGTATGTCCTGAGACGAATTCAGCAGCTT GAAGATGAGGTGAAGAGAGTCCAGAACAACAACACCTTACGCAAAGAAGAGAAAATTGCA ATCATGAGGGAGAGGCACACAGCTTTGATGAAGCCCATCGTATTTGCTTTGGAGCATGTG AGGAGTATCACAGCGGCTCCTGCAGAAACACCTCATGAAAAATGGTTTCAGGATAACTAT GGTGATGCCATTGAAAATGCCCTAGAAAAACTGAAGACTCCATTGAACCCTGCAAAGCCT GGGAGCAGCTGGATTCCATTTAAAGAGATAATGCTAAGTTTGCAACAGAGAGCACAGAAA CGTGCAAGTTACATCTTGCGTCTTGAAGAAATCAGTCCATGGTTGGCTGCCATGACTAAC ACTGAAATTGCTCTTCCTGGGGAAGTCTCAGCCAGAGACACTGTCACAATCCATAGTGTG GGCGGAACCATCACAATCTTACCGACTAAAACCAAGCCAAAGAAACTTCTCTTTCTTGGA TCAGATGGGAAGAGCTATCCTTATCTTTTCAAAGGACTGGAGGATTTACATCTGGATGAG AGAATAATGCAGTTCCTATCTATTGTGAATACCATGTTTGCTACAATTAATCGCCAAGAA ACACCCCGGTTCCATGCTCGACACTATTCTGTAACACCACTAGGAACAAGATCAGGACTA ATCCAGTGGGTAGATGGAGCCACACCCTTATTTGGTCTTTACAAACGATGGCAACAACGG GAAGCTGCCTTACAAGCACAAAAGGCCCAAGATTCCTACCAAACTCCTCAGAATCCTGGA ATTGTACCCCGTCCTAGTGAACTTTATTACAGTAAAATTGGCCCTGCTTTGAAAACAGTT GGGCTTAGCCTGGATGTGTCCCGTCGGGATTGGCCTCTTCATGTAATGAAGGCAGTATTG GAAGAGTTAATGGAGGCCACACCCCCGAATCTCCTTGCCAAAGAGCTCTGGTCATCTTGC ACAACACCTGATGAATGGTGGAGAGTTACGCAGTCTTATGCAAGATCTACTGCAGTCATG TCTATGGTTGGATACATAATTGGCCTTGGAGACAGACATCTGGATAATGTTCTTATAGAT ATGACGACTGGAGAAGTTGTTCACATAGATTACAATGTTTGCTTTGAAAAAGGTAAAAGC CTTAGAGTTCCTGAGAAAGTACCTTTTCGAATGACACAAAACATTGAAACAGCACTGGGT GTAACTGGAGTAGAAGGTGTATTTAGGCTTTCATGTGAGCAGGTTTTACACATTATGCGG CGTGGCAGAGAGACCCTGCTGACGCTGCTGGAGGCCTTTGTGTACGACCCTCTGGTGGAC TGGACAGCAGGAGGCGAGGCTGGGTTTGCTGGTGCTGTCTATGGTGGAGGTGGCCAGCAG GCCGAGAGCAAGCAGAGCAAGAGAGAGATGGAGCGAGAGATCACCCGCAGCCTGTTTTCT TCTAGAGTAGCTGAGATTAAGGTGAACTGGTTTAAGAATAGAGATGAGATGCTGGTTGTG CTTCCCAAGTTGGACGGTAGCTTAGATGAATACCTAAGCTTGCAAGAGCAACTGACAGAT GTGGAAAAACTGCAGGGCAAACTACTGGAGGAAATAGAGTTTCTAGAAGGAGCTGAAGGG GTGGATCATCCTTCTCATACTCTGCAACACAGGTATTCTGAGCACACCCAACTACAGACT CAGCAAAGAGCTGTTCAGGAAGCAATCCAGGTGAAGCTGAATGAATTTGAACAATGGATA ACACATTATCAGGCTGCATTCAATAATTTAGAAGCAACACAGCTTGCAAGCTTGCTTCAA GAGATAAGCACACAAATGGACCTTGGTCCTCCAAGTTACGTGCCAGCAACAGCCTTTCTG CAGAATGCTGGTCAGGCCCACTTGATTAGCCAGTGCGAGCAGCTGGAGGGGGAGGTTGGT GCTCTCCTGCAGCAGAGGCGCTCCGTGCTCCGTGGCTGTCTGGAGCAACTGCATCACTAT GCAACCGTGGCCCTGCAGTATCCGAAGGCCATATTTCAGAAACATCGAATTGAACAGTGG AAGACCTGGATGGAAGAGCTCATCTGTAACACCACAGTAGAGCGTTGTCAAGAGCTCTAT AGGAAATATGAAATGCAATATGCTCCCCAGCCACCCCCAACAGTGTGTCAGTTCATCACT GCCACTGAAATGACCCTGCAGCGATACGCAGCAGACATCAACAGCAGACTTATTAGACAA GTGGAACGCTTGAAACAGGAAGCTGTCACTGTGCCAGTTTGTGAAGATCAGTTGAAAGAA ATTGAACGTTGCATTAAAGTTTTCCTTCATGAGAATGGAGAAGAAGGATCTTTGAGTCTA GCAAGTGTTATTATTTCTGCCCTTTGTACCCTTACAAGGCGTAACCTGATGATGGAAGGT GCAGCGTCAAGTGCTGGAGAACAGCTGGTTGATCTGACTTCTCGGGATGGAGCCTGGTTC TTGGAGGAACTCTGCAGTATGAGCGGAAACGTCACCTGCTTGGTTCAGTTACTGAAGCAG TGCCACCTGGTGCCACAGGACTTAGATATCCCGAACCCCATGGAAGCGTCTGAGACAGTT CACTTAGCCAATGGAGTGTATACCTCACTTCAGGAATTGAATTCGAATTTCCGGCAAATC ATATTTCCAGAAGCACTTCGATGTTTAATGAAAGGGGAATACACGTTAGAAAGTATGCTG CATGAACTGGACGGTCTTATTGAGCAGACCACCGATGGCGTTCCCCTGCAGACTCTAGTG GAATCTCTTCAGGCCTACTTAAGAAACGCAGCTATGGGACTGGAAGAAGAAACACATGCT CATTACATCGATGTTGCCAGACTACTACATGCTCAGTACGGTGAATTAATCCAACCGAGA AATGGTTCAGTTGATGAAACACCCAAAATGTCAGCTGGCCAGATGCTTTTGGTAGCATTC GATGGCATGTTTGCTCAAGTTGAAACTGCTTTCAGCTTATTAGTTGAAAAGTTGAACAAG ATGGAAATTCCCATAGCTTGGCGAAAGATTGACATCATAAGGGAAGCCAGGAGTACTCAA GTTAATTTTTTTGATGATGATAATCACCGGCAGGTGCTAGAAGAGATTTTCTTTCTAAAA AGACTACAGACTATTAAGGAGTTCTTCAGGCTCTGTGGTACCTTTTCTAAAACATTGTCA GGATCAAGTTCACTTGAAGATCAGAATACTGTGAATGGGCCTGTACAGATTGTCAATGTG AAAACCCTTTTTAGAAACTCTTGTTTCAGTGAAGACCAAATGGCCAAACCTATCAAGGCA TTCACAGCTGACTTTGTGAGGCAGCTCTTGATAGGGCTACCCAACCAAGCCCTCGGACTC ACACTGTGCAGTTTTATCAGTGCTCTGGGTGTAGACATCATTGCTCAAGTAGAGGCAAAG GACTTTGGTGCCGAAAGCAAAGTTTCTGTTGATGATCTCTGTAAGAAAGCGGTGGAACAT AACATCCAGATAGGGAAGTTCTCTCAGCTGGTTATGAACAGGGCAACTGTGTTAGCAAGT TCTTACGACACTGCCTGGAAGAAGCATGACTTGGTGCGAAGGCTAGAAACCAGTATTTCT TCTTGTAAGACAAGCCTGCAGCGGGTTCAGCTGCATATTGCCATGTTTCAGTGGCAACAT GAAGATCTACTTATCAATAGACCACAAGCCATGTCAGTCACACCTCCCCCACGGTCTGCT ATCCTAACCAGCATGAAAAAGAAGCTGCATACCCTGAGCCAGATTGAAACTTCTATTGCG ACAGTTCAGGAGAAGCTAGCTGCACTTGAATCAAGTATTGAACAGCGACTCAAGTGGGCA GGTGGTGCCAACCCTGCATTGGCCCCTGTACTACAAGATTTTGAAGCAACGATAGCTGAA AGAAGAAATCTTGTCCTTAAAGAGAGCCAAAGAGCAAGTCAGGTCACATTTCTCTGCAGC AATATCATTCATTTTGAAAGTTTACGAACAAGAACTGCAGAAGCCTTAAACCTGGATGCG GCGTTATTTGAACTAATCAAGCGATGTCAGCAGATGTGTTCGTTTGCATCACAGTTTAAC AGTTCAGTGTCTGAGTTAGAGCTTCGTTTATTACAGAGAGTGGACACTGGTCTTGAACAT CCTATTGGCAGCTCTGAATGGCTTTTGTCAGCACACAAACAGTTGACCCAGGATATGTCT ACTCAGAGGGCAATTCAGACAGAGAAAGAGCAGCAGATAGAAACGGTCTGTGAAACAATT CAGAATCTGGTTGATAATATAAAGACTGTGCTCACTGGTCATAACCGACAGCTTGGAGAT GTCAAACATCTCTTGAAAGCTATGGCTAAGGATGAAGAAGCTGCTCTGGCAGATGGTGAA GATGTTCCCTATGAGAACAGTGTTAGGCAGTTTTTGGGTGAATATAAATCATGGCAAGAC AACATTCAAACAGTTCTATTTACATTAGTCCAGGCTATGGGTCAGGTTCGAAGTCAAGAA CACGTTGAAATGCTCCAGGAAATCACTCCCACCTTGAAAGAACTGAAAACACAAAGTCAG AGTATCTATAATAATTTAGTGAGTTTTGCATCACCCTTAGTCACCGATGCAACAAATGAA TGTTCGAGTCCAACGTCATCTGCTACTTATCAGCCATCCTTCGCTGCAGCAGTCCGGAGT AACACTGGCCAGAAGACTCAGCCTGATGTCATGTCACAGAATGCTAGAAAGCTGATCCAG AAAAATCTTGCTACATCAGCTGATACTCCACCAAGCACCGTTCCAGGAACTGGCAAGAGT GTTGCTTGTAGTCCTAAAAAGGCAGTCAGAGACCCTAAAACTGGGAAAGCGGTGCAAGAG AGAAACTCCTATGCAGTGAGTGTGTGGAAGAGAGTGAAAGCCAAGTTAGAGGGCCGAGAT GTTGATCCGAATAGGAGGATGTCAGTTGCTGAACAGGTTGACTATGTCATTAAGGAAGCA ACTAATCTAGATAACTTGGCTCAGCTGTATGAAGGTTGGACAGCCTGGGTGTGA |
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Protein Properties | |||||||
Number of Residues | 3657 | ||||||
Molecular Weight | 410257.6 | ||||||
Theoretical pI | 6.43 | ||||||
Pfam Domain Function | |||||||
Signals |
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Transmembrane Regions |
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Protein Sequence |
>Serine/threonine-protein kinase SMG1 MSRRAPGSRLSSGGTNYSRSWNDWQPRTDSASADPGNLKYSSSRDRGGSSSYGLQPSNSA VVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRVNNVTSPEFTSVQHG SRALATKDMRKSQERSMSYSDESRLSNLLRRITREDDRDRRLATVKQLKEFIQQPENKLV LVKQLDNILAAVHDVLNESSKLLQELRQEGACCLGLLCASLSYEAEKIFKWIFSKFSSSA KDEVKLLYLCATYKALETVGEKKAFSSVMQLVMTSLQSILENVDTPELLCKCVKCILLVA RCYPHIFSTNFRDTVDILVGWHIDHTQKPSLTQQVSGWLQSLEPFWVADLAFSTTLLGQF LEDMEAYAEDLSHVASGESVDEDVPPPSVSLPKLAALLRVFSTVVRSIGERFSPIRGPPI TEAYVTDVLYRVMRCVTAANQVFFSEAVLTAANECVGVLLGSLDPSMTIHCDMVITYGLD QLENCQTCGTDYIISVLNLLTLIVEQINTKLPSSFVEKLFIPSSKLLFLRYHKEKEVVAV AHAVYQAVLSLKNIPVLETAYKLILGEMTCALNNLLHSLQLPEACSEIKHEAFKNHVFNV DNAKFVVKFDLSALTTIGNAKNSLIGMWALSPTVFALLSKNLMIVHSDLAVHFPAIQYAV LYTLYSHCTRHDHFISSSLSSASPSLFDGAVISTVTTATKKHFSIILNLLGILLKKDNLN QDTRKLLMTWALEAAVLMRKSETYAPLFSLPSFHKFCKGLLANTLVEDVNICLQACSSLH ALSSSLPDDLLQRCVDVCRVQLVHSGTRIRQAFGKLLKSIPLDVVLSNNNHTEIQEISLA LRSHMSKAPSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKRDQSTIPRN LLKTDAVLWQWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQW TTADNDEGHGNNQLRLVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTFFYTNRQTCQ DWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMKTTSLSQGNELEVTIMMVVEALCELH CPEAIQGIAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCCISSFDK SVLTLANAGRNSASPKHSLNGESRKTVLSKPTDSSPEVINYLGNKACEFYISIADWAAVQ EWQNAIHDLKKSTSSTSLNLKADFNYIKSLSSFESGKFVECTEQLELLPGENINLLAGGS KEKIDMKKLLPNMLSPDPRELQKSIEVQLLRSSVCLATALNPIEQDQKWQSITENVVKYL KQTSRIAIGPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSNRLSTEDCLIPLFSEALRS CKQHDVRPWMQALRYTMYQNQLLEKIKEQTVPIRSHLMELGLTAAKFARKRGNVSLATRL LAQCSEVQLGKTTTAQDLVQHFKKLSTQGQVDEKWGPELDIEKTKLLYTAGQSTHAMEML SSCAISFCKSVKAEYAVAKSILTLAKWIQAEWKEISGQLKQVYRAQHQQNFTGLSTLSKN ILTLIELPSVNTMEEEYPRIESESTVHIGVGEPDFILGQLYHLSSVQAPEVAKSWAALAS WAYRWGRKVVDNASQGEGVRLLPREKSEVQNLLPDTITEEEKERIYGILGQAVCRPAGIQ DEDITLQITESEDNEEDDMVDVIWRQLISSCPWLSELDESATEGVIKVWRKVVDRIFSLY KLSCSAYFTFLKLNAGQIPLDEDDPRLHLSHRVEQSTDDMIVMATLRLLRLLVKHAGELR QYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLCRVAQDSPHLILYPAIVGT ISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSGLNEDQA MMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLRRIQQL EDEVKRVQNNNTLRKEEKIAIMREKHTALMKPIVFALEHVRSITAAPAETPHEKWFQDNY GDAIENALEKLKTPLNPAKPGSSWIPFKEIMLSLQQRAQKRASYILRLEEISPWLAAMTN TEIALPGEVSARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDE RIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQR EAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVL EELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLID MTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMR RGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAVYGGGGQQAESKQSKREMEREITRSLFS SRVAEIKVNWFKNRDEMLVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLEGAEG VDHPSHTLQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWITHYQAAFNNLEATQLASLLQ EISTQMDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQLHHY ATVALQYPKAIFQKHRIEQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVCQFIT ATEMTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEGSLSL ASVIISALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQLLKQ CHLVPQDLDIPNPMEASETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYTLESML HELDGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHYIDVARLLHAQYGELIQPR NGSVDETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKIDIIREARSTQ VNFFDDDNHRQVLEEIFFLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQIVNV KTLFRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFISALGVDIIAQVEAK DFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLASSYDTAWKKHDLVRRLETSIS SCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTLSQIETSIA TVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQRASQVTFLCS NIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDTGLEH PIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGD VKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNIQTVLFTLVQAMGQVRSQE HVEMLQEITPTLKELKTQSQSIYNNLVSFASPLVTDATNECSSPTSSATYQPSFAAAVRS NTGQKTQPDVMSQNARKLIQKNLATSADTPPSTVPGTGKSVACSPKKAVRDPKTGKAVQE RNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAWV |
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External Links | |||||||
GenBank ID Protein | 16506130 | ||||||
UniProtKB/Swiss-Prot ID | Q96Q15 | ||||||
UniProtKB/Swiss-Prot Entry Name | SMG1_HUMAN | ||||||
PDB IDs | Not Available | ||||||
GenBank Gene ID | AB061371 | ||||||
GeneCard ID | SMG1 | ||||||
GenAtlas ID | SMG1 | ||||||
HGNC ID | HGNC:30045 | ||||||
References | |||||||
General References |
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