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Identification
HMDB Protein ID HMDBP08951
Secondary Accession Numbers
  • 14680
Name Receptor-type tyrosine-protein phosphatase T
Synonyms
  1. R-PTP-T
  2. RPTP-rho
  3. Receptor-type tyrosine-protein phosphatase rho
Gene Name PTPRT
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function May be involved in both signal transduction and cellular adhesion in the CNS.
Pathways Not Available
Reactions
Protein tyrosine phosphate + Water → protein tyrosine + Phosphate details
GO Classification
Biological Process
homophilic cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Component
cell surface
plasma membrane
integral to membrane
Component
membrane
cell part
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
Molecular Function
thiolester hydrolase activity
alpha-catenin binding
gamma-catenin binding
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location 20
Locus 20q12-q13
SNPs PTPRT
Gene Sequence
>4392 bp
ATGGCGAGCCTCGCCGCGCTCGCCCTCAGCCTGCTCCTGAGGCTGCAGCTGCCGCCACTG
CCCGGCGCCCGGGCTCAGAGCGCCCCAGGTGGCTGTTCCTTTGATGAGCACTACAGCAAC
TGTGGTTATAGTGTGGCTCTAGGGACCAATGGGTTCACCTGGGAGCAGATTAACACAACG
GAGAAACCAATGCTGGACCAGGCAGTGCCCACAGGATCTTTCATGATGGTGAACAGCTCT
GGGAGAGCCTCTGGCCAGAAGGCCCACCTTCTCCTGCCAACCCTGAAGGAGAATGACACC
CACTGCATCGACTTCCATTACTACTTCTCCAGCCGTGACAGGTCCAGCCCAGGGGCCTTG
AACGTCTACGTGAAGGTGAATGGTGGCCCCCAAGGGAACCCTGTGTGGAATGTGTCCGGG
GTCGTCACTGAGGGCTGGGTGAAGGCAGAGCTCGCCATCAGCACTTTCTGGCCACATTTC
TATCAGGTGATATTTGAATCCGTCTCATTGAAGGGTCATCCTGGCTACATCGCCGTGGAC
GAGGTCCGGGTCCTTGCTCATCCATGCAGAAAAGCACCTCATTTTCTGCGACTCCAAAAC
GTGGAGGTGAATGTGGGGCAGAATGCCACATTTCAGTGCATTGCTGGTGGGAAGTGGTCT
CAGCATGACAAGCTTTGGCTCCAGCAATGGAATGGCAGGGACACGGCCCTGATGGTCACC
CGTGTGGTCAACCACAGGCGCTTCTCAGCCACAGTCAGTGTGGCAGACACTGCCCAGCGG
AGCGTCAGCAAGTACCGCTGTGTGATCCGCTCTGATGGTGGGTCTGGTGTGTCCAACTAC
GCGGAGCTGATCGTGAAAGAGCCTCCCACGCCCATTGCTCCCCCAGAGCTGCTGGCTGTG
GGGGCCACATACCTGTGGATCAAGCCAAATGCCAACTCCATCATCGGGGATGGCCCCATC
ATCCTGAAGGAAGTGGAATATCGCACCACCACAGGCACGTGGGCAGAGACCCACATAGTC
GACTCTCCCAACTATAAGCTGTGGCATCTGGACCCCGATGTTGAGTATGAGATCCGAGTG
CTCCTCACACGACCAGGTGAGGGGGGTACGGGACCGCCAGGGGCTCCCCTCACCACCAGG
ACCAAGTGTGCAGATCCGGTACATGGCCCACAGAACGTGGAAATCGTAGACATCAGAGCC
CGGCAGCTGACCCTGCAGTGGGAGCCCTTCGGCTACGCGGTGACCCGCTGCCATAGCTAC
AACCTCACCGTGCAGTACCAGTATGTGTTCAACCAGCAGCAGTACGAGGCCGAGGAGGTC
ATCCAGACCTCCTCCCACTACACCCTGCGAGGCCTGCGCCCCTTCATGACCATCCGGCTG
CGACTCTTGCTGTCTAACCCCGAGGGCCGAATGGAGAGCGAGGAGCTGGTGGTGCAGACT
GAGGAAGACGTTCCAGGAGCTGTTCCTCTAGAATCCATCCAAGGGGGGCCCTTTGAGGAG
AAGATCTACATCCAGTGGAAACCTCCCAATGAGACCAATGGGGTCATCACGCTCTACGAG
ATCAACTACAAGGCTGTCGGCTCGCTGGACCCAAGTGCTGACCTCTCGAGCCAGAGGGGG
AAAGTGTTCAAGCTCCGGAATGAAACCCACCACCTCTTTGTGGGTCTGTACCCAGGGACC
ACCTATTCCTTCACCATCAAGGCCAGCACAGCAAAGGGCTTTGGGCCCCCTGTCACCACT
CGGATTGCCACCAAAATTTCAGCTCCATCCATGCCTGAGTACGACACAGACACCCCATTG
AATGAGACAGACACGACCATCACAGTGATGCTGAAACCCGCTCAGTCCCGGGGAGCTCCT
GTCAGTGTTTATCAGCTGGTTGTCAAGGAGGAGCGACTTCAGAAGTCACGGAGGGCAGCT
GACATTATTGAGTGCTTTTCGGTGCCCGTGAGCTATCGGAATGCCTCCAGCCTCGATTCT
CTACACTACTTTGCTGCTGAGTTGAAGCCTGCCAACCTGCCTGTCACCCAGCCATTTACA
GTGGGTGACAATAAGACATACAATGGCTACTGGAACCCTCCTCTCTCTCCCCTGAAAAGC
TACAGCATCTACTTCCAGGCACTCAGCAAAGCCAATGGAGAGACCAAAATCAACTGTGTT
CGTCTGGCTACAAAAGCACCAATGGGCAGCGCCCAGGTGACCCCGGGGACTCCACTCTGC
CTCCTCACCACAGGTGCCTCCACCCAGAATTCTAACACTGTGGAGCCAGAGAAGCAGGTG
GACAACACCGTGAAGATGGCTGGCGTGATCGCTGGCCTCCTCATGTTCATCATCATTCTC
CTGGGCGTGATGCTCACCATCAAAAGGAGAAGAAATGCTTATTCCTACTCCTATTACTTG
TCCCAAAGGAAGCTGGCCAAGAAGCAGAAGGAGACCCAGAGTGGAGCCCAGAGGGAGATG
GGGCCTGTGGCCTCTGCCGACAAACCCACCACCAAGCTCAGCGCCAGCCGCAATGATGAA
GGCTTCTCTTCTAGTTCTCAGGACGTCAACGGATTCACAGATGGCAGCCGCGGGGAGCTT
TCCCAGCCCACCCTCACGATCCAGACTCATCCCTACCGCACCTGTGACCCTGTGGAGATG
AGCTACCCCCGGGACCAGTTCCAACTCGCCATCCGGGTGGCTGACTTGCTGCAGCACATC
ACGCAGATGAAGAGAGGCCAGGGCTACGGGTTCAAGGAGGAATACGAGGCCTTACCAGAG
GGGCAGACAGCTTCGTGGGACACAGCCAAGGAGGATGAAAACCGCAATAAGAATCGATAT
GGGAACATCATATCCTACGACCATTCCCGGGTGAGGCTGCTGGTGCTGGATGGAGACCCG
CACTCTGACTACATCAATGCCAACTACATTGACGGATACCATCGACCTCGGCACTACATT
GCGACTCAAGGTCCGATGCAGGAGACTGTAAAGGACTTTTGGAGAATGATCTGGCAGGAG
AACTCCGCCAGCATCGTCATGGTCACAAACCTGGTGGAAGTGGGCAGGGTGAAATGTGTG
CGATACTGGCCAGATGACACGGAGGTCTACGGAGACATTAAAGTCACCCTGATTGAAACA
GAGCCCCTGGCAGAATACGTCATACGCACCTTCACAGTCCAGAAGAAAGGCTACCATGAG
ATCCGGGAGCTCCGCCTCTTCCACTTCACCAGCTGGCCTGACCACGGCGTTCCCTGCTAT
GCCACTGGCCTTCTGGGCTTCGTCCGCCAGGTCAAGTTCCTCAACCCCCCGGAAGCTGGG
CCCATAGTGGTCCACTGCAGTGCTGGGGCTGGGCGGACTGGCTGCTTCATTGCCATTGAC
ACCATGCTTGACATGGCCGAGAATGAAGGGGTGGTGGACATCTTCAACTGCGTGCGTGAG
CTCCGGGCCCAAAGGGTCAACCTGGTACAGACAGAGGAGCAATATGTGTTTGTGCACGAT
GCCATCCTGGAAGCGTGCCTCTGTGGCAACACTGCCATCCCTGTGTGTGAGTTCCGTTCT
CTCTACTACAATATCAGCAGGCTGGACCCCCAGACAAACTCCAGCCAAATCAAAGATGAA
TTTCAGACCCTCAACATTGTGACACCCCGTGTGCGGCCCGAGGACTGCAGCATTGGGCTC
CTGCCCCGGAACCATGATAAGAATCGAAGTATGGACGTGCTGCCTCTGGACCGCTGCCTG
CCCTTCCTTATCTCAGTGGACGGAGAATCCAGCAATTACATCAACGCAGCACTGATGGAT
AGCCACAAGCAGCCTGCCGCCTTCGTGGTCACCCAGCACCCTCTACCCAACACCGTGGCA
GACTTCTGGAGGCTGGTGTTCGATTACAACTGCTCCTCTGTGGTGATGCTGAATGAGATG
GACACTGCCCAGTTCTGTATGCAGTACTGGCCTGAGAAGACCTCCGGGTGCTATGGGCCC
ATCCAGGTGGAGTTCGTCTCCGCAGACATCGACGAGGACATCATCCACAGAATATTCCGC
ATCTGTAACATGGCCCGGCCACAGGATGGTTATCGTATAGTCCAGCACCTCCAGTACATT
GGCTGGCCTGCCTACCGGGACACGCCCCCCTCCAAGCGCTCTCTGCTCAAAGTGGTCCGA
CGACTGGAGAAGTGGCAGGAGCAGTATGACGGGAGGGAGGGACGTACTGTGGTCCACTGC
CTAAATGGGGGAGGCCGTAGTGGAACCTTCTGTGCCATCTGCAGTGTGTGTGAGATGATC
CAGCAGCAAAACATCATTGACGTGTTCCACATCGTGAAAACACTGCGTAACAACAAATCC
AACATGGTGGAGACCCTGGAACAGTATAAATTTGTATACGAGGTGGCACTGGAATATTTA
AGCTCCTTTTAG
Protein Properties
Number of Residues 1463
Molecular Weight 162132.92
Theoretical pI 6.893
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Receptor-type tyrosine-protein phosphatase T
MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW
EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL
NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD
EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT
RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV
GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV
LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY
NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT
EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG
KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL
NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS
LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV
RLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIIL
LGVMLTIKRRRNAYSYSYYLSQRKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDE
GFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHI
TQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDP
HSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCV
RYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCY
ATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRE
LRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDE
FQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMD
SHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGP
IQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVR
RLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKS
NMVETLEQYKFVYEVALEYLSSF
GenBank ID Protein 6554165
UniProtKB/Swiss-Prot ID O14522
UniProtKB/Swiss-Prot Entry Name PTPRT_HUMAN
PDB IDs
GenBank Gene ID AF043644
GeneCard ID PTPRT
GenAtlas ID PTPRT
HGNC ID HGNC:9682
References
General References
  1. Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [PubMed:11780052 ]
  2. Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K, Dooling D, Dunford-Shore BH, McGrath S, Hickenbotham M, Cook L, Abbott R, Larson DE, Koboldt DC, Pohl C, Smith S, Hawkins A, Abbott S, Locke D, Hillier LW, Miner T, Fulton L, Magrini V, Wylie T, Glasscock J, Conyers J, Sander N, Shi X, Osborne JR, Minx P, Gordon D, Chinwalla A, Zhao Y, Ries RE, Payton JE, Westervelt P, Tomasson MH, Watson M, Baty J, Ivanovich J, Heath S, Shannon WD, Nagarajan R, Walter MJ, Link DC, Graubert TA, DiPersio JF, Wilson RK: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature. 2008 Nov 6;456(7218):66-72. doi: 10.1038/nature07485. [PubMed:18987736 ]
  3. Ohara O, Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Nomura N: Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. DNA Res. 1997 Feb 28;4(1):53-9. [PubMed:9179496 ]
  4. McAndrew PE, Frostholm A, White RA, Rotter A, Burghes AH: Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system. Brain Res Mol Brain Res. 1998 May;56(1-2):9-21. [PubMed:9602027 ]
  5. Besco JA, Frostholm A, Popesco MC, Burghes AH, Rotter A: Genomic organization and alternative splicing of the human and mouse RPTPrho genes. BMC Genomics. 2001;2:1. Epub 2001 Jun 8. [PubMed:11423001 ]
  6. Besco JA, Frostholm A, Popesco MC, Burghes AH, Rotter A: Genomic organization and alternative splicing of the human and mouse RPTPrho genes: Correction. BMC Genomics. 2001;2:5. Epub 2001 Aug 14. [PubMed:11814386 ]
  7. Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE: Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science. 2004 May 21;304(5674):1164-6. [PubMed:15155950 ]