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Identification
HMDB Protein ID HMDBP08960
Secondary Accession Numbers
  • 14690
Name Putative tyrosine-protein phosphatase TPTE
Synonyms
  1. CT44
  2. Cancer/testis antigen 44
  3. Transmembrane phosphatase with tensin homology
  4. Tumor antigen BJ-HCC-5
Gene Name TPTE
Protein Type Enzyme
Biological Properties
General Function Involved in protein tyrosine/serine/threonine phosphatase activity
Specific Function Could be involved in signal transduction.
Pathways Not Available
Reactions
Protein tyrosine phosphate + Water → protein tyrosine + Phosphate details
GO Classification
Biological Process
signal transduction
Cellular Component
integral to membrane
Component
membrane
cell part
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
protein tyrosine/serine/threonine phosphatase activity
transporter activity
ion channel activity
Molecular Function
protein tyrosine/serine/threonine phosphatase activity
ion channel activity
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
establishment of localization
transport
cellular metabolic process
transmembrane transport
ion transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location 21
Locus 21p11
SNPs TPTE
Gene Sequence
>1656 bp
ATGAATGAAAGTCCTGATCCGACTGACCTGGCGGGAGTCATCATTGAGCTCGGCCCCAAT
GACAGTCCACAGACAAGTGAATTTAAAGGAGCAACCGAGGAGGCACCTGCGAAAGAAAGC
CCACACACAAGTGAATTTAAAGGAGCAGCCCGGGTGTCACCTATCAGTGAAAGTGTGTTA
GCACGACTTTCCAAGTTTGAAGTTGAAGATGCTGAAAATGTTGCTTCATATGACAGCAAG
ATTAAGAAAATTGTGCATTCAATTGTATCATCCTTTGCATTTGGACTATTTGGAGTTTTC
CTGGTCTTACTGGATGTCACTCTCATCCTTGCCGACCTAATTTTCACTGACAGCAAACTT
TATATTCCTTTGGAGTATCGTTCTATTTCTCTAGCTATTGCCTTATTTTTTCTCATGGAT
GTTCTTCTTCGAGTATTTGTAGAAAGGAGACAGCAGTATTTTTCTGACTTATTTAACATT
TTAGATACTGCCATTATTGTGATTCTTCTGCTGGTTGATGTCGTTTACATTTTTTTTGAC
ATTAAGTTGCTTAGGAATATTCCCAGATGGACACATTTACTTCGACTTCTACGACTTATT
ATTCTGTTAAGAATTTTTCATCTGTTTCATCAAAAAAGACAACTTGAAAAGCTGATAAGA
AGGCGGGTTTCAGAAAACAAAAGGCGATACACAAGGGATGGATTTGACCTAGACCTCACT
TACGTTACAGAACGTATTATTGCTATGTCATTTCCATCTTCTGGAAGGCAGTCTTTCTAT
AGAAATCCAATCAAGGAAGTTGTGCGGTTTCTAGATAAGAAACACCGAAACCACTATCGA
GTCTACAATCTATGCAGTGAAAGAGCTTACGATCCTAAGCACTTCCATAATAGGGTCGTT
AGAATCATGATTGATGATCATAATGTCCCCACTCTACATCAGATGGTGGTTTTCACCAAG
GAAGTAAATGAGTGGATGGCTCAAGATCTTGAAAACATCGTAGCGATTCACTGTAAAGGA
GGCACAGATAGAACAGGAACTATGGTTTGTGCCTTCCTTATTGCCTCTGAAATATGTTCA
ACTGCAAAGGAAAGCCTGTATTATTTTGGAGAAAGGCGAACAGATAAAACCCACAGCGAA
AAATTTCAGGGAGTAGAAACTCCTTCTCAGAAGAGATATGTTGCATATTTTGCACAAGTG
AAACATCTCTACAACTGGAATCTCCCTCCAAGACGGATACTCTTTATAAAACACTTCATT
ATTTATTCGATTCCTCGTTATGTACGTGATCTAAAAATCCAAATAGAAATGGAGAAAAAG
GTTGTCTTTTCCACTATTTCATTAGGAAAATGTTCGGTACTTGATAACATTACAACAGAC
AAAATATTAATTGATGTATTCGACGGTCCACCTCTGTATGATGATGTGAAAGTGCAGTTT
TTCTATTCGAATCTTCCTACATACTATGACAATTGCTCATTTTACTTCTGGTTGCACACA
TCTTTTATTGAAAATAACAGGCTTTATCTACCAAAAAATGAATTGGATAATCTACATAAA
CAAAAAGCACGGAGAATTTATCCATCAGATTTTGCCGTGGAGATACTTTTTGGCGAGAAA
ATGACTTCCAGTGATGTTGTAGCTGGATCCGATTAA
Protein Properties
Number of Residues 551
Molecular Weight 62440.68
Theoretical pI 8.452
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Putative tyrosine-protein phosphatase TPTE
MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESPHTSEFKGAARVSPISESVL
ARLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKL
YIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFD
IKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLT
YVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVV
RIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICS
TAKESLYYFGERRTDKTHSEKFQGVKTPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFI
IYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTDKILIDVFDGPPLYDDVKVQF
FYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEK
MTSSDVVAGSD
GenBank ID Protein 3549240
UniProtKB/Swiss-Prot ID P56180
UniProtKB/Swiss-Prot Entry Name TPTE_HUMAN
PDB IDs Not Available
GenBank Gene ID AF007118
GeneCard ID TPTE
GenAtlas ID TPTE
HGNC ID HGNC:12023
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  3. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML: The DNA sequence of human chromosome 21. Nature. 2000 May 18;405(6784):311-9. [PubMed:10830953 ]
  4. Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, Hutter P, Antonarakis SE: The TPTE gene family: cellular expression, subcellular localization and alternative splicing. Gene. 2003 Dec 24;323:189-99. [PubMed:14659893 ]
  5. Chen H, Rossier C, Morris MA, Scott HS, Gos A, Bairoch A, Antonarakis SE: A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y. Hum Genet. 1999 Nov;105(5):399-409. [PubMed:10598804 ]