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Identification
HMDB Protein ID HMDBP09048
Secondary Accession Numbers
  • 14790
Name tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial
Synonyms Not Available
Gene Name TRMT61B
Protein Type Unknown
Biological Properties
General Function Involved in tRNA (adenine-N1-)-methyltransferase activity
Specific Function Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (decephering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (decephering codons UCA, UCU, UCG or UCC).
Pathways Not Available
Reactions
S-Adenosylmethionine + adenine(58) in tRNA → S-Adenosylhomocysteine + N(1)-methyladenine(58) in tRNA details
GO Classification
Biological Process
mitochondrial tRNA methylation
protein homooligomerization
Cellular Component
tRNA (m1A) methyltransferase complex
mitochondrion
Function
catalytic activity
transferase activity
rna methyltransferase activity
trna methyltransferase activity
trna (adenine) methyltransferase activity
trna (adenine-n1-)-methyltransferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
Molecular Function
tRNA (adenine-N1-)-methyltransferase activity
Process
rna metabolic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna modification
rna methylation
trna methylation
Cellular Location Not Available
Gene Properties
Chromosome Location 2
Locus 2p23.2
SNPs TRMT61B
Gene Sequence
>1434 bp
ATGCTAATGGCATGGTGCCGCGGTCCTGTCTTGCTGTGCCTGCGGCAGGGGCTCGGAACC
AATTCATTCCTGCACGGCCTGGGGCAGGAGCCCTTCGAGGGAGCTCGGTCACTGTGTTGC
AGGTCCTCGCCTAGAGACCTGCGAGATGGAGAAAGAGAGCACGAGGCGGCACAAAGGAAA
GCCCCAGGAGCAGAGTCTTGCCCATCTCTCCCTCTGAGCATCTCGGACATTGGGACTGGA
TGTCTTTCGTCACTGGAAAACCTCAGACTGCCGACGCTGCGGGAAGAGTCATCCCCTCGA
GAGCTCGAGGACTCGAGCGGAGACCAGGGCCGGTGCGGTCCCACACACCAGGGATCCGAG
GATCCTTCGATGCTCTCGCAGGCCCAGTCCGCTACCGAGGTCGAAGAGCGTCACGTCTCC
CCTTCTTGTTCAACTTCCAGAGAGAGACCCTTTCAGGCTGGGGAACTGATTTTAGCTGAG
ACTGGGGAGGGAGAAACAAAATTTAAGAAATTATTTAGGTTGAACAACTTCGGACTCTTA
AATAGTAACTGGGGGGCAGTCCCGTTCGGCAAGATCGTGGGGAAGTTCCCCGGCCAGATA
CTGAGGAGTTCCTTCGGTAAGCAGTACATGCTGAGGAGGCCAGCCTTGGAAGACTATGTA
GTATTGATGAAAAGAGGGACTGCCATAACATTCCCAAAGGATATTAATATGATTCTCTCA
ATGATGGATATCAACCCAGGTGATACTGTTTTGGAAGCTGGCTCAGGCTCTGGTGGAATG
AGCTTATTTTTATCCAAAGCAGTTGGATCACAAGGACGAGTCATAAGTTTTGAGGTACGA
AAAGACCACCATGATCTGGCTAAGAAGAATTACAAACACTGGCGTGATTCATGGAAATTA
AGTCATGTAGAAGAGTGGCCAGACAATGTGGATTTTATTCATAAGGACATTTCAGGAGCA
ACCGAAGACATAAAATCTTTAACATTTGACGCAGTAGCTTTGGATATGTTAAATCCTCAT
GTTACTTTGCCTGTTTTTTACCCACATCTTAAGCATGGTGGTGTATGTGCTGTATATGTA
GTAAACATCACACAGGTTATTGAACTTTTAGATGGAATTCGCACCTGTGAACTTGCTCTT
TCATGTGAAAAGATAAGCGAGGTCATTGTCAGAGATTGGTTGGTTTGCCTTGCAAAACAG
AAAAATGGAATTTTAGCTCAAAAAGTAGAATCTAAAATCAACACAGATGTACAACTAGAT
TCTCAAGAGAAAATTGGAGTTAAAGGTGAGCTGTTTCAAGAGGATGACCATGAAGAATCG
CATTCTGATTTTCCATATGGATCATTTCCCTATGTTGCTAGACCAGTACACTGGCAACCT
GGTCATACAGCTTTTCTTGTCAAGTTGAGGAAGGTCAAACCACAACTTAACTGA
Protein Properties
Number of Residues 477
Molecular Weight 52964.87
Theoretical pI 6.626
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Potential tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61B
MLMAWCRGPVLLCLRQGLGTNSFLHGLGQEPFEGARSLCCRSSPRDLRDGEREHEAAQRK
APGAESCPSLPLSISDIGTGCLSSLENLRLPTLREESSPRELEDSSGDQGRCGPTHQGSE
DPSMLSQAQSATEVEERHVSPSCSTSRERPFQAGELILAETGEGETKFKKLFRLNNFGLL
NSNWGAVPFGKIVGKFPGQILRSSFGKQYMLRRPALEDYVVLMKRGTAITFPKDINMILS
MMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKL
SHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHLKHGGVCAVYV
VNITQVIELLDGIRTCELALSCEKISEVIVRDWLVCLAKQKNGILAQKVESKINTDVQLD
SQEKIGVKGELFQEDDHEESHSDFPYGSFPYVARPVHWQPGHTAFLVKLRKVKPQLN
GenBank ID Protein 62988627
UniProtKB/Swiss-Prot ID Q9BVS5
UniProtKB/Swiss-Prot Entry Name TR61B_HUMAN
PDB IDs
GenBank Gene ID AC097720
GeneCard ID TRMT61B
GenAtlas ID TRMT61B
HGNC ID HGNC:26070
References
General References
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