Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP09061
Secondary Accession Numbers
  • 14803
Name Neurofascin
Synonyms Not Available
Gene Name NFASC
Protein Type Unknown
Biological Properties
General Function Posttranslational modification, protein turnover, chaperones
Specific Function Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 1q32.1
SNPs NFASC
Gene Sequence
>3723 bp
ATGGCCAGGCAGCCACCGCCGCCCTGGGTCCATGCAGCCTTCCTCCTCTGCCTCCTCAGT
CTTGGCGGAGCCATCGAAATTCCTATGGATCCAAGCATTCAGAATGAGCTGACGCAGCCG
CCAACCATCACCAAGCAGTCAGCGAAGGATCACATCGTGGACCCCCGTGATAACATCCTG
ATTGAGTGTGAAGCAAAAGGGAACCCTGCCCCCAGCTTCCACTGGACACGAAACAGCAGA
TTCTTCAACATCGCCAAGGACCCCCGGGTGTCCATGAGGAGGAGGTCTGGGACCCTGGTG
ATTGACTTCCGCAGTGGCGGGCGGCCGGAGGAATATGAGGGGGAATATCAGTGCTTCGCC
CGCAACAAATTTGGCACGGCCCTGTCCAATAGGATCCGCCTGCAGGTGTCTAAATCTCCT
CTGTGGCCCAAGGAAAACCTAGACCCTGTCGTGGTCCAAGAGGGCGCTCCTTTGACGCTC
CAGTGCAACCCCCCGCCTGGACTTCCATCCCCGGTCATCTTCTGGATGAGCAGCTCCATG
GAGCCCATCACCCAAGACAAACGTGTCTCTCAGGGCCATAACGGAGACCTATACTTCTCC
AACGTGATGCTGCAGGACATGCAGACCGACTACAGTTGTAACGCCCGCTTCCACTTCACC
CACACCATCCAGCAGAAGAACCCTTTCACCCTCAAGGTCCTCACCACCCGAGGAGTTGCA
GAAAGAACACCAAGCTTCATGTATCCCCAGGGCACCGCGAGCAGCCAGATGGTGCTTCGT
GGCATGGACCTCCTGCTGGAATGCATCGCCTCCGGGGTCCCAACACCAGACATCGCATGG
TACAAGAAAGGTGGGGACCTCCCATCTGATAAGGCCAAGTTTGAGAACTTTAATAAGGCC
CTGCGTATCACAAATGTCTCTGAGGAAGACTCCGGGGAGTATTTCTGCCTGGCCTCCAAC
AAGATGGGCAGCATCCGGCACACGATCTCGGTGAGAGTAAAGGCTGCTCCCTACTGGCTG
GACGAACCCAAGAACCTTATTCTGGCTCCTGGCGAGGATGGGAGACTGGTGTGTCGAGCC
AATGGAAACCCCAAACCCACTGTCCAGTGGATGGTGAATGGGGAACCTTTGCAATCGGCA
CCACCTAACCCAAACCGTGAGGTGGCCGGAGACACCATCATCTTCCGGGACACCCAGATC
AGCAGCAGGGCTGTGTACCAGTGCAACACCTCCAACGAGCATGGCTACCTGCTGGCCAAC
GCCTTTGTCAGTGTGCTGGATGTGCCGCCTCGGATGCTGTCGCCCCGGAACCAGCTCATT
CGAGTGATTCTTTACAACCGGACGCGGCTGGACTGCCCTTTCTTTGGGTCTCCCATCCCC
ACACTGCGATGGTTTAAGAATGGGCAAGGAAGCAACCTGGATGGTGGCAACTACCATGTT
TATGAGAACGGCAGTCTGGAAATTAAGATGATCCGCAAAGAGGACCAGGGCATCTACACC
TGTGTCGCCACCAACATCCTGGGCAAAGCTGAAAACCAAGTCCGCCTGGAGGTCAAAGAC
CCCACCAGGATCTACCGGATGCCCGAGGACCAGGTGGCCAGAAGGGGCACCACGGTGCAG
CTGGAGTGTCGGGTGAAGCACGACCCCTCCCTGAAACTCACCGTCTCCTGGCTGAAGGAT
GACGAGCCGCTCTATATTGGAAACAGGATGAAGAAGGAAGACGACTCCCTGACCATCTTT
GGGGTGGCAGAGCGGGACCAGGGCAGTTACACGTGTGTCGCCAGCACCGAGCTAGACCAA
GACCTGGCCAAGGCCTACCTCACCGTGCTAGCTGATCAGGCCACTCCAACTAACCGTTTG
GCTGCCCTGCCCAAAGGACGGCCAGACCGGCCCCGGGACCTGGAGCTGACCGACCTGGCC
GAGAGGAGCGTGCGGCTGACCTGGATCCCCGGGGATGCTAACAACAGCCCCATCACAGAC
TACGTCGTCCAGTTTGAAGAAGACCAGTTCCAACCTGGGGTCTGGCATGACCATTCCAAG
TACCCCGGCAGCGTTAACTCAGCCGTCCTCCGGCTGTCCCCGTATGTCAACTACCAGTTC
CGTGTCATTGCCATCAACGAGGTTGGGAGCAGCCACCCCAGCCTCCCATCCGAGCGCTAC
CGAACCAGTGGAGCACCCCCCGAGTCCAATCCTGGTGACGTGAAGGGAGAGGGGACCAGA
AAGAACAACATGGAGATCACGTGGACGCCCATGAATGCCACCTCGGCCTTTGGCCCCAAC
CTGCGCTACATTGTCAAGTGGAGGCGGAGAGAGACTCGAGAGGCCTGGAACAACGTCACA
GTGTGGGGCTCTCGCTACGTGGTGGGGCAGACCCCAGTCTACGTGCCCTATGAGATCCGA
GTCCAGGCTGAAAATGACTTCGGGAAGGGCCCTGAGCCAGAGTCCGTCATCGGTTACTCC
GGAGAAGATTTACCCAGTGCCCCTAGGCGTTTCCGAGTCCGGCAGCCCAACCTGGAGACA
ATCAACCTGGAATGGGATCATCCTGAGCATCCAAATGGGATCATGATTGGATACACTCTC
AAATATGTGGCCTTTAACGGGACCAAAGTAGGAAAGCAGATAGTGGAAAACTTCTCTCCC
AATCAGACCAAGTTCACGGTGCAAAGAACGGACCCCGTGTCACGCTACCGCTTTACCCTC
AGCGCCAGGACGCAGGTGGGCTCTGGGGAAGCCGTCACAGAGGAGTCACCAGCACCCCCG
AATGAAGCTACTCCAACCGCAGCTCCTCCCACATTGCCCCCGACTACCGTGGGTGCGACG
GGCGCTGTGAGCAGTACCGATGCTACTGCCATTGCTGCCACCACCGAAGCCACAACAGTC
CCCATCATCCCAACTGTCGCACCTACCACCATCGCCACCACCACCACCGTCGCCACAACT
ACTACAACCACTGCTGCCGCCACCACCACCACGGAGAGTCCTCCCACCACCACCTCCGGG
ACTAAGATACACGAATCCGCCCCTGATGAGCAGTCCATATGGAACGTCACGGTGCTCCCC
AACAGTAAATGGGCCAACATCACCTGGAAGCACAATTTCGGGCCCGGAACTGACTTTGTG
GTTGAGTACATCGACAGCAACCATACGAAAAAAACTGTCCCAGTTAAGGCCCAGGCTCAG
CCTATACAGCTGACAGACCTCTATCCCGGGATGACATACACGTTGCGGGTTTATTCCCGG
GACAACGAGGGCATCAGCAGTACCGTCATCACCTTTATGACCAGTACAGCTTACACCAAC
AACCAAGCGGACATCGCCACCCAGGGCTGGTTCATTGGGCTTATGTGCGCCATCGCCCTC
CTGGTGCTGATCCTGCTCATCGTCTGTTTCATCAAGAGGAGTCGCGGCGGCAAGTACCCA
GTACGAGAAAAGAAGGATGTTCCCCTTGGCCCTGAAGACCCCAAGGAAGAGGATGGCTCA
TTTGACTATAGTGATGAGGACAACAAGCCCCTGCAGGGCAGTCAGACATCTCTGGACGGC
ACCATCAAGCAGCAGGAGAGTGACGACAGCCTGGTGGACTATGGCGAGGGTGGCGAGGGT
CAGTTCAATGAAGACGGCTCCTTCATCGGCCAGTACACGGTCAAAAAGGACAAGGAGGAA
ACAGAGGGCAACGAAAGCTCAGAGGCCACGTCACCTGTCAATGCTATCTACTCTCTGGCC
TAA
Protein Properties
Number of Residues 1347
Molecular Weight 150025.7
Theoretical pI 6.61
Pfam Domain Function
Signals
  • 1-24
Transmembrane Regions
  • 1218-1238
Protein Sequence
>Neurofascin
MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL
IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA
RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM
EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA
ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA
LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA
NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN
AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV
YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ
LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ
DLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITD
YVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERY
RTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVT
VWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNST
AISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFP
YSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNG
IMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVT
EESPAPPNEATPTAAPPTLPPTTVGATGAVSSTDATAIAATTEATTVPIIPTVAPTTIAT
TTTVATTTTTTAAATTTTESPPTTTSGTKIHESAPDEQSIWNVTVLPNSKWANITWKHNF
GPGTDFVVEYIDSNHTKKTVPVKAQAQPIQLTDLYPGMTYTLRVYSRDNEGISSTVITFM
TSTAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKDVPLGPED
PKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYT
VKKDKEETEGNESSEATSPVNAIYSLA
GenBank ID Protein 237858675
UniProtKB/Swiss-Prot ID O94856
UniProtKB/Swiss-Prot Entry Name NFASC_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001005388
GeneCard ID NFASC
GenAtlas ID NFASC
HGNC ID HGNC:29866
References
General References
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