Human Metabolome Database: Showing Protein Membrane transport protein XK (HMDBP09097)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification
HMDB Protein ID	HMDBP09097
Secondary Accession Numbers	14841
Name	Membrane transport protein XK
Synonyms	Kell complex 37 kDa component Kx antigen XK-related protein 1
Gene Name	XK
Protein Type	Unknown
Biological Properties
General Function	Involved in protein binding
Specific Function	May be involved in sodium-dependent transport of neutral amino acids or oligopeptides
Pathways	Not Available
Reactions	Not Available
GO Classification	Not Available
Cellular Location	Membrane Multi-pass membrane protein (Potential)
Gene Properties
Chromosome Location	Not Available
Locus	Not Available
SNPs	XK
Gene Sequence	>1335 bp ATGAAATTCCCGGCCTCGGTGCTGGCGTCCGTGTTCCTGTTCGTGGCCGAGACAACGGCG GCGCTCAGCCTGAGCAGCACCTACCGCTCGGGCGGGGACCGCATGTGGCAGGCGCTGACG TTGCTTTTCTCGCTACTGCCTTGCGCGCTCGTGCAGCTCACGCTTCTCTTCGTACACCGC GACCTCAGCCGCGACCGCCCGCTCGTACTGCTGCTGCACCTGCTGCAACTTGGGCCCCTT TTCAGGTGTTTTGAAGTCTTCTGCATCTACTTTCAGTCAGGCAACAATGAAGAGCCTTAT GTCAGTATCACCAAGAAGAGGCAAATGCCAAAAAATGGCCTCTCAGAGGAGATTGAGAAG GAGGTGGGCCAGGCAGAAGGCAAACTAATCACCCACCGATCAGCGTTCAGCCGGGCGTCG GTGATCCAGGCTTTCTTGGGCTCAGCCCCCCAGCTGACCCTACAGCTGTACATAAGTGTC ATGCAGCAGGACGTCACTGTTGGAAGAAGTCTCCTCATGACCATATCCCTGTTGTCCATT GTGTATGGAGCCTTGCGCTGCAACATCCTAGCCATCAAAATCAAGTACGATGAGTATGAA GTCAAAGTGAAGCCTCTGGCCTATGTCTGTATCTTCCTGTGGAGGAGCTTTGAGATTGCC ACTCGAGTTGTAGTCCTGGTCCTCTTTACCTCCGTCCTGAAGACCTGGGTGGTGGTTATA ATACTCATCAACTTCTTCAGTTTGTTCTTGTACCCCTGGATCCTCTTCTGGTGCAGTGGT TCCCCATTCCCTGAGAACATAGAGAAGGCCCTCAGTAGAGTGGGCACCACCATTGTACTA TGCTTTCTAACTTTACTCTATACTGGTATCAACATGTTCTGCTGGTCTGCTGTACAGCTG AAAATTGACAGCCCTGACCTCATCAGCAAGTCCCATAATTGGTACCAGCTACTGGTGTAT TACATGATAAGATTCATCGAGAATGCCATCCTCCTCCTCCTGTGGTATCTTTTCAAGACT GACATCTATATGTATGTGTGCGCACCTCTGTTGGTCCTGCAGCTGCTCATTGGGTACTGC ACAGCCATTCTCTTCATGCTTGTATTCTATCAGTTCTTCCACCCTTGCAAAAAGCTCTTT TCTTCCAGTGTTTCTGAAGGCTTTCAGAGGTGGCTCAGGTGTTTTTGCTGGGCCTGCAGG CAGCAAAAACCCTGTGAGCCGATAGGAAAGGAAGATCTACAGTCATCCAGAGATAGAGAT GAGACACCTTCTAGCAGTAAAACAAGTCCTGAGCCTGGTCAGTTCTTGAATGCTGAAGAT CTCTGCTCTGCTTAA
Protein Properties
Number of Residues	444
Molecular Weight	50901.6
Theoretical pI	8.32
Pfam Domain Function	XK-related (PF09815 )
Signals	None
Transmembrane Regions	3-23 38-58 69-89 141-161 172-192 209-229 236-256 278-298 318-338 350-370
Protein Sequence	>Membrane transport protein XK MKFPASVLASVFLFVAETTAALSLSSTYRSGGDRMWQALTLLFSLLPCALVQLTLLFVHR DLSRDRPLVLLLHLLQLGPLFRCFEVFCIYFQSGNNEEPYVSITKKRQMPKNGLSEEIEK EVGQAEGKLITHRSAFSRASVIQAFLGSAPQLTLQLYISVMQQDVTVGRSLLMTISLLSI VYGALRCNILAIKIKYDEYEVKVKPLAYVCIFLWRSFEIATRVVVLVLFTSVLKTWVVVI ILINFFSFFLYPWILFWCSGSPFPENIEKALSRVGTTIVLCFLTLLYTGINMFCWSAVQL KIDSPDLISKSHNWYQLLVYYMIRFIENAILLLLWYLFKTDIYMYVCAPLLVLQLLIGYC TAILFMLVFYQFFHPCKKLFSSSVSEGFQRWLRCFCWACRQQKPCEPIGKEDLQSSRDRD ETPSSSKTSPEPGQFLNAEDLCSA
External Links
GenBank ID Protein	46948351
UniProtKB/Swiss-Prot ID	P51811
UniProtKB/Swiss-Prot Entry Name	XK_HUMAN
PDB IDs	Not Available
GenBank Gene ID	AY534238
GeneCard ID	XK
GenAtlas ID	XK
HGNC ID	HGNC:12811
References
General References	Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ] Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ] Ho M, Chelly J, Carter N, Danek A, Crocker P, Monaco AP: Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein. Cell. 1994 Jun 17;77(6):869-80. [PubMed:8004674 ] Khamlichi S, Bailly P, Blanchard D, Goossens D, Cartron JP, Bertrand O: Purification and partial characterization of the erythrocyte Kx protein deficient in McLeod patients. Eur J Biochem. 1995 Mar 15;228(3):931-4. [PubMed:7737196 ] Russo D, Redman C, Lee S: Association of XK and Kell blood group proteins. J Biol Chem. 1998 May 29;273(22):13950-6. [PubMed:9593744 ] Danek A, Rubio JP, Rampoldi L, Ho M, Dobson-Stone C, Tison F, Symmans WA, Oechsner M, Kalckreuth W, Watt JM, Corbett AJ, Hamdalla HH, Marshall AG, Sutton I, Dotti MT, Malandrini A, Walker RH, Daniels G, Monaco AP: McLeod neuroacanthocytosis: genotype and phenotype. Ann Neurol. 2001 Dec;50(6):755-64. [PubMed:11761473 ] Russo DC, Lee S, Reid ME, Redman CM: Point mutations causing the McLeod phenotype. Transfusion. 2002 Mar;42(3):287-93. [PubMed:11961232 ] Jung HH, Hergersberg M, Vogt M, Pahnke J, Treyer V, Rothlisberger B, Kollias SS, Russo D, Frey BM: McLeod phenotype associated with a XK missense mutation without hematologic, neuromuscular, or cerebral involvement. Transfusion. 2003 Jul;43(7):928-38. [PubMed:12823753 ]