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Identification
HMDB Protein ID HMDBP09181
Secondary Accession Numbers
  • 14939
Name A-kinase anchor protein 10, mitochondrial
Synonyms
  1. AKAP-10
  2. D-AKAP-2
  3. Dual specificity A kinase-anchoring protein 2
  4. PRKA10
  5. Protein kinase A-anchoring protein 10
Gene Name AKAP10
Protein Type Enzyme
Biological Properties
General Function Involved in signal transducer activity
Specific Function Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase
Pathways Not Available
Reactions Not Available
GO Classification
Function
molecular transducer activity
signal transducer activity
Cellular Location
  1. Cytoplasm
  2. Mitochondrion
  3. Membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 17p11.1
SNPs AKAP10
Gene Sequence
>1989 bp
ATGAGGGGAGCCGGGCCCTCCCCGCGCCAGTCCCCCCGCACCCTCCGTCCCGACCCGGGC
CCCGCCATGTCCTTCTTCCGGCGGAAAGTGAAAGGCAAAGAACAAGAGAAGACCTCAGAT
GTGAAGTCCATTAAAGCTTCAATATCCGTACATTCCCCACAAAAAAGCACTAAAAATCAT
GCCTTGCTGGAGGCTGCAGGACCAAGTCATGTTGCAATCAATGCCATTTCTGCCAACATG
GACTCCTTTTCAAGTAGCAGGACAGCCACACTTAAGAAGCAGCCAAGCCACATGGAGGCT
GCTCATTTTGGTGACCTGGGCAGATCTTGTCTGGACTACCAGACTCAAGAGACCAAATCA
AGCCTTTCTAAGACCCTTGAACAAGTCTTGCACGACACTATTGTCCTCCCTTACTTCATT
CAATTCATGGAACTTCGGCGAATGGAGCATTTGGTGAAATTTTGGTTAGAGGCTGAAAGT
TTTCATTCAACAACTTGGTCGCGAATAAGAGCACACAGTCTAAACACAATGAAGCAGAGC
TCACTGGCTGAGCCTGTCTCTCCATCTAAAAAGCATGAAACTACAGCGTCTTTTTTAACT
GATTCTCTTGATAAGAGATTGGAGGATTCTGGCTCAGCACAGTTGTTTATGACTCATTCA
GAAGGAATTGACCTGAATAATAGAACTAACAGCACTCAGAATCACTTGCTGCTTTCCCAG
GAATGTGACAGTGCCCATTCTCTCCGTCTTGAAATGGCCAGAGCAGGAACTCACCAAGTT
TCCATGGAAACCCAAGAATCTTCCTCTACACTTACAGTAGCCAGTAGAAATAGTCCCGCT
TCTCCACTAAAAGAATTGTCAGGAAAACTAATGAAAAGTATAGAACAAGATGCAGTGAAT
ACTTTTACCAAATATATATCTCCAGATGCTGCTAAACCAATACCAATTACAGAAGCAATG
AGAAATGACATCATAGCAAGGATTTGTGGAGAAGATGGACAGGTGGATCCCAACTGTTTC
GTTTTGGCACAGTCCATAGTCTTTAGTGCAATGGAGCAAGAGCACTTTAGTGAGTTTCTG
CGAAGTCACCATTTCTGTAAATACCAGATTGAAGTGCTGACCAGTGGAACTGTTTACCTG
GCTGACATTCTCTTCTGTGAGTCAGCCCTCTTTTATTTCTCTGAGTACATGGAAAAAGAG
GATGCAGTGAATATCTTACAATTCTGGTTGGCAGCAGATAACTTCCAGTCTCAGCTTGCT
GCCAAAAAGGGGCAATATGATGGACAGGAGGCACAGAATGATGCCATGATTTTATATGAC
AAGTACTTCTCCCTCCAAGCCACACATCCTCTTGGATTTGATGATGTTGTACGATTAGAA
ATTGAATCCAATATCTGCAGGGAAGGTGGGCCACTCCCCAACTGTTTCACAACTCCATTA
CGTCAGGCCTGGACAACCATGGAGAAGGTCTTTTTGCCTGGCTTTCTGTCCAGCAATCTT
TATTATAAATATTTGAATGATCTCATCCATTCGGTTCGAGGAGATGAATTTCTGGGCGGG
AACGTGTCGCCGACTGCTCCTGGCTCTGTTGGCCCTCCTGATGAGTCTCACCCAGGGAGT
TCTGACAGCTCTGCGTCTCAGTCCAGTGTGAAAAAAGCCAGTATTAAAATACTGAAAAAT
TTTGATGAAGCGATAATTGTGGATGCGGCAAGTCTGGATCCAGAATCTTTATATCAACGG
ACATATGCCGGGAAGATGACATTTGGAAGAGTGAGTGACTTGGGGCAATTCATCCGGGAA
TCTGAGCCTGAACCTGATGTAAGGAAATCAAAAGGATCCATGTTCTCACAAGCTATGAAG
AAATGGGTGCAAGGAAATACTGATGAGGCCCAGGAAGAGCTAGCTTGGAAGATTGCTAAA
ATGATAGTCAGTGACATTATGCAGCAGGCTCAGTATGATCAACCGTTAGAGAAATCTACA
AAGTTATGA
Protein Properties
Number of Residues 662
Molecular Weight 73817.5
Theoretical pI 6.35
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>A-kinase anchor protein 10, mitochondrial
MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNH
ALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQETKS
SLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQS
SLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQ
ECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASRNSPASPLKELSGKLMKSIEQDAVN
TFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFL
RSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLA
AKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPL
RQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFLGGNVSLTAPGSVGPPDESHPGS
SDSSASQSSVKKASIKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRE
SEPEPDVRKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKST
KL
GenBank ID Protein 2707344
UniProtKB/Swiss-Prot ID O43572
UniProtKB/Swiss-Prot Entry Name AKA10_HUMAN
PDB IDs Not Available
GenBank Gene ID AF037439
GeneCard ID AKAP10
GenAtlas ID AKAP10
HGNC ID HGNC:368
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
  4. Wang L, Sunahara RK, Krumins A, Perkins G, Crochiere ML, Mackey M, Bell S, Ellisman MH, Taylor SS: Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3220-5. [PubMed:11248059 ]