Human Metabolome Database: Showing Protein Fructosamine-3-kinase (HMDBP09190)

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Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification
HMDB Protein ID	HMDBP09190
Secondary Accession Numbers	14948
Name	Fructosamine-3-kinase
Synonyms	Not Available
Gene Name	FN3K
Protein Type	Enzyme
Biological Properties
General Function	Carbohydrate transport and metabolism
Specific Function	May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme
Pathways	Not Available
Reactions	Not Available
GO Classification	Not Available
Cellular Location	Not Available
Gene Properties
Chromosome Location	Chromosome:1
Locus	17q25.3
SNPs	FN3K
Gene Sequence	>930 bp ATGGAGCAGCTGCTGCGCGCCGAGCTGCGCACCGCGACCCTGCGGGCCTTCGGCGGCCCC GGCGCCGGCTGCATCAGCGAGGGCCGAGCCTACGACACGGACGCAGGCCCAGTGTTCGTC AAAGTCAACCGCAGGACGCAGGCCCGGCAGATGTTTGAGGGGGAGGTGGCCAGCCTGGAG GCCCTCCGGAGCACGGGCCTGGTGCGGGTGCCGAGGCCCATGAAGGTCATCGACCTGCCG GGAGGTGGGGCCGCCTTTGTGATGGAGCATTTGAAGATGAAGAGCTTGAGCAGTCAAGCA TCAAAACTTGGAGAGCAGATGGCAGATTTGCATCTTTACAACCAGAAGCTCAGGGAGAAG TTGAAGGAGGAGGAGAACACAGTGGGCCGAAGAGGTGAGGGTGCTGAGCCTCAGTATGTG GACAAGTTCGGCTTCCACACGGTGACGTGCTGCGGCTTCATCCCGCAGGTGAATGAGTGG CAGGATGACTGGCCGACCTTTTTCGCCCGGCACCGGCTCCAGGCGCAGCTGGACCTCATT GAGAAGGACTATGCTGACCGAGAGGCACGAGAACTCTGGTCCCGGCTACAGGTGAAGATC CCGGATCTGTTTTGTGGCCTAGAGATTGTCCCCGCGTTGCTCCACGGGGATCTCTGGTCG GGAAACGTGGCTGAGGACGACGTGGGGCCCATTATTTACGACCCGGCTTCCTTCTATGGC CATTCCGAGTTTGAACTGGCAATCGCCTTGATGTTTGGGGGGTTCCCCAGATCCTTCTTC ACCGCCTACCACCGGAAGATCCCCAAGGCTCCGGGCTTCGACCAGCGGCTGCTGCTCTAC CAGCTGTTTAACTACCTGAACCACTGGAACCACTTCGGGCGGGAGTACAGGAGCCCTTCC TTGGGCACCATGCGAAGGCTGCTCAAGTAG
Protein Properties
Number of Residues	309
Molecular Weight	35170.9
Theoretical pI	7.64
Pfam Domain Function	Fructosamin_kin (PF03881 )
Signals	None
Transmembrane Regions	None
Protein Sequence	>Fructosamine-3-kinase MEQLLRAELRTATLRAFGGPGAGCISEGRAYDTDAGPVFVKVNRRTQARQMFEGEVASLE ALRSTGLVRVPRPMKVIDLPGGGAAFVMEHLKMKSLSSQASKLGEQMADLHLYNQKLREK LKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLI EKDYADREARELWSRLQVKIPDLFCGLEIVPALLHGDLWSGNVAEDDVGPIIYDPASFYG HSEFELAIALMFGGFPRSFFTAYHRKIPKAPGFDQRLLLYQLFNYLNHWNHFGREYRSPS LGTMRRLLK
External Links
GenBank ID Protein	11191737
UniProtKB/Swiss-Prot ID	Q9H479
UniProtKB/Swiss-Prot Entry Name	FN3K_HUMAN
PDB IDs	Not Available
GenBank Gene ID	AJ404615
GeneCard ID	FN3K
GenAtlas ID	FN3K
HGNC ID	HGNC:24822
References
General References	Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ] Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9. [PubMed:17924679 ] Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E: Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase. Diabetes. 2000 Oct;49(10):1627-34. [PubMed:11016445 ]