Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP09202
Secondary Accession Numbers
  • 14976
Name Probable tRNA pseudouridine synthase 1
Synonyms Not Available
Gene Name TRUB1
Protein Type Enzyme
Biological Properties
General Function Involved in RNA processing
Specific Function May be responsible for synthesis of pseudouridine from uracil in transfer RNAs
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
nucleic acid binding
isomerase activity
pseudouridine synthase activity
intramolecular transferase activity
rna binding
Process
rna metabolic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna processing
rna modification
pseudouridine synthesis
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:1
Locus 10q25.3
SNPs TRUB1
Gene Sequence
>1050 bp
ATGGCCGCTTCTGAGGCGGCGGTGGTGTCTTCGCCGTCTTTGAAAACAGACACATCCCCT
GTCCTTGAAACTGCAGGAACGGTCGCAGCAATGGCTGCGACCCCGTCAGCAAGGGCTGCA
GCCGCGGTGGTTGCGGCCGCGGCCAGGACCGGATCCGAAGCCAGGGTCTCCAAGGCCGCT
TTGGCTACCAAGCTGCTGTCCTTGAGCGGCGTGTTCGCCGTGCACAAGCCCAAAGGGCCC
ACTTCAGCCGAGCTGCTGAATCGGTTGAAGGAGAAGCTGCTGGCAGAAGCTGGAATGCCT
TCTCCAGAATGGACCAAGAGGAAAAAGCAGACTTTGAAAATTGGGCATGGAGGGACTCTA
GACAGCGCAGCCCGAGGAGTTCTGGTTGTTGGAATTGGAAGCGGAACAAAAATGTTGACC
AGTATGTTGTCAGGGTCCAAGAGATATACTGCCATTGGAGAACTGGGGAAAGCTACTGAT
ACACTAGATTCTACGGGGAGGGTAACAGAAGAAAAACCTTACGATAAAATAACACAAGAA
GATATTGAAGGCATTCTACAGAAATTTACTGGAAATATAATGCAAGTGCCCCCCCTCTAT
TCTGCATTAAAGAAAGATGGACAAAGACTTTCGACTTTGATGAAGAGAGGTGAAGTCGTA
GAAGCAAAACCTGCCAGGCCAGTGACTGTATACAGTATCTCCCTTCAAAAATTCCAGCCA
CCATTTTTCACATTAGATGTTGAATGTGGAGGAGGTTTTTATATCAGAAGCTTGGTCAGT
GACATTGGAAAAGAACTATCTTCCTGTGCCAATGTGCTAGAGCTGACCCGAACCAAACAG
GGACCATTTACGCTAGAAGAACATGCCCTTCCTGAAGACAAATGGACAATTGATGACATT
GCACAGTCTCTTGAGCATTGCTCATCTCTTTTCCCAGCAGAGTTGGCACTTAAAAAATCA
AAACCTGAGTCTAATGAACAGGTTTTGAGCTGTGAATATATAACTCTAAATGAGCCAAAG
AGAGAAGATGATGTAATTAAGACGTGTTGA
Protein Properties
Number of Residues 349
Molecular Weight 37252.4
Theoretical pI 8.45
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Probable tRNA pseudouridine synthase 1
MAASEAAVVSSPSLKTDTSPVLETAGTVAAMAATPSARAAAAVVAAAARTGSEARVSKAA
LATKLLSLSGVFAVHKPKGPTSAELLNRLKEKLLAEAGMPSPEWTKRKKQTLKIGHGGTL
DSAARGVLVVGIGSGTKMLTSMLSGSKRYTAIGELGKATDTLDSTGRVTEEKPYDKITQE
DIEGILQKFTGNIMQVPPLYSALKKDGQRLSTLMKRGEVVEAKPARPVTVYSISLQKFQP
PFFTLDVECGGGFYIRSLVSDIGKELSSCANVLELTRTKQGPFTLEEHALPEDKWTIDDI
AQSLEHCSSLFPAELALKKSKPESNEQVLSCEYITLNEPKREDDVIKTC
GenBank ID Protein 17484109
UniProtKB/Swiss-Prot ID Q8WWH5
UniProtKB/Swiss-Prot Entry Name TRUB1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF448144
GeneCard ID TRUB1
GenAtlas ID TRUB1
HGNC ID HGNC:16060
References
General References
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  3. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
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  6. Zucchini C, Strippoli P, Biolchi A, Solmi R, Lenzi L, D'Addabbo P, Carinci P, Valvassori L: The human TruB family of pseudouridine synthase genes, including the Dyskeratosis Congenita 1 gene and the novel member TRUB1. Int J Mol Med. 2003 Jun;11(6):697-704. [PubMed:12736709 ]