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Identification
HMDB Protein ID HMDBP09218
Secondary Accession Numbers
  • 15000
Name Very-long-chain enoyl-CoA reductase
Synonyms
  1. Synaptic glycoprotein SC2
  2. TER
  3. Trans-2,3-enoyl-CoA reductase
Gene Name TECR
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity, acting on the CH-CH group of donors
Specific Function Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids.
Pathways
  • Biosynthesis of unsaturated fatty acids
  • Fatty acid elongation
Reactions
A very-long-chain acyl-CoA + NADP → a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH details
GO Classification
Biological Process
very long-chain fatty acid biosynthetic process
long-chain fatty-acyl-CoA biosynthetic process
triglyceride biosynthetic process
fatty acid elongation
Cellular Component
integral to endoplasmic reticulum membrane
Component
cell part
intracellular part
cytoplasm
membrane part
intrinsic to membrane
integral to membrane
Function
oxidoreductase activity, acting on the ch-ch group of donors
catalytic activity
oxidoreductase activity
Molecular Function
oxidoreductase activity, acting on the CH-CH group of donors
Process
metabolic process
primary metabolic process
lipid metabolic process
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location 19
Locus 19p13.12
SNPs TECR
Gene Sequence
>927 bp
ATGAAGCATTACGAGGTGGAGATTCTGGACGCAAAGACAAGGGAGAAGCTGTGTTTCTTG
GACAAGGTGGAGCCCCACGCCACCATTGCGGAGATCAAGAACCTCTTCACTAAGACCCAT
CCGCAGTGGTACCCCGCCCGCCAGTCCCTCCGCCTGGACCCCAAGGGCAAGTCCCTGAAG
GATGAGGATGTTCTGCAGAAGCTGCCCGTGGGACCACGCGCACACCTGTACTTCCGGGAC
CTGGGGGCCCAGATCAGCTGGGTGACGGTCTTCCTAACAGAGTACGCGGGGCCCCTTTTC
ATCTACCTGCTCTTCTACTTCCGAGTGCCCTTCATCTATGGCCACAAATATGACTTTACG
TCCAGTCGGCATACAGTGGTGCACCTCGCCTGCATCTGTCACTCATTCCACTACATCAAG
CGCCTGCTGGAGACGCTCTTCGTGCACCGCTTCTCCCATGGCACTATGCCTTTGCGCAAC
ATCTTTAAGAACTGCACCTACTACTGGGGCTTCGCCGCGTGGATGGCCTATTACATCAAT
CACCCTCTCTACACTCCCCCTACCTACGGAGCTCAGCAGGTGAAACTGGCGCTCGCCATC
TTTGTGATCTGCCAGCTCGGCAACTTCTCCATCCACATGGCCCTGCGGGACCTGCGGCCC
GCTGGGTCCAAGACGCGGAAGATCCCATACCCCACCAAGAACCCCTTCACGTGGCTCTTC
CTGCTGGTGTCCTGCCCCAACTGCACCTACGAGGTGGGGTCCTGGATCGGTTTCGCCATC
ATGACGCAGTGTCTCCCAGTGGCCCTGTTCTCCCTGGTGGGCTTCACCCAGATGACCATC
TGGGCCAAGGGCAAGCACCGCAGCTACCTGAAGGAGTTCCGGGACTACCCGCCCCTGCGC
ATGCCCATCATCCCCTTCCTGCTCTGA
Protein Properties
Number of Residues 308
Molecular Weight 36034.065
Theoretical pI 9.445
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Trans-2,3-enoyl-CoA reductase
MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLK
DEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGHKYDFT
SSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYIN
HPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLF
LLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLR
MPIIPFLL
GenBank ID Protein 3329386
UniProtKB/Swiss-Prot ID Q9NZ01
UniProtKB/Swiss-Prot Entry Name TECR_HUMAN
PDB IDs
GenBank Gene ID AF038958
GeneCard ID TECR
GenAtlas ID TECR
HGNC ID HGNC:4551
References
General References
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