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Identification
HMDB Protein ID HMDBP09233
Secondary Accession Numbers
  • 15050
Name Aminopeptidase O
Synonyms
  1. AP-O
Gene Name AOPEP
Protein Type Enzyme
Biological Properties
General Function Involved in binding
Specific Function Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
transition metal ion binding
zinc ion binding
peptidase activity
peptidase activity, acting on l-amino acid peptides
metallopeptidase activity
Process
metabolic process
macromolecule metabolic process
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
monocarboxylic acid metabolic process
fatty acid metabolic process
leukotriene biosynthetic process
protein metabolic process
proteolysis
unsaturated fatty acid metabolic process
icosanoid metabolic process
leukotriene metabolic process
Cellular Location
  1. Cytoplasm (Potential)
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs AOPEP
Gene Sequence
>2460 bp
ATGGACATACAGCTGGACCCTGCCAGAGATGACCTGCCTCTCATGGCCAACACCAGCCAC
ATACTTGTGAAGCACTATGTACTGGATTTGGATGTGGATTTTGAAAGTCAAGTCATTGAG
GGGACCATAGTGCTTTTCCTCGAGGATGGAAACAGATTCAAGAAACAGAATAGCTCTATT
GAGGAAGCCTGCCAATCAGAATCAAACAAAGCCTGCAAATTTGGGATGCCTGAACCCTGC
CATATTCCCGTGACAAATGCAAGGACCTTCTCATCTGAAATGGAATATAATGATTTTGCA
ATCTGTAGTAAAGGTGAAAAAGATACTTCTGATAAAGATGGTAACCATGACAACCAGGAA
CATGCTTCTGGGATTTCTAGCTCAAAGTACTGCTGTGACACAGGGAATCATGGGAGTGAG
GATTTTTTGCTAGTGTTGGACTGCTGTGATTTATCTGTGTTAAAAGTCGAGGAGGTGGAT
GTTGCTGCTGTGCCAGGTCTGGAAAAATTTACAAGGTCTCCTGAGCTCACGGTTGTTTCT
GAGGAGTTCAGGAATCAGATTGTACGTGAACTTGTGACTTTGCCTGCAAATCGTTGGAGG
GAGCAGTTAGACTATTACGCTCGCTGCAGCCAGGCTCCTGGCTGTGGGGAACTCCTCTTT
GACACTGACACTTGGAGCTTGCAGATAAGGAAGACAGGGGCTCAGACAGCTACTGACTTT
CCTCATGCTATCAGGATATGGTACAAAACTAAACCTGAAGGGCGATCGGTTACATGGACC
TCAGACCAGAGTGGCAGGCCATGTGTTTATACTGTGGGATCTCCCATAAACAACAGGGCC
CTTTTTCCATGCCAGGAGCCACCCGTTGCCATGTCAACATGGCAGGCTACAGTTCGAGCA
GCTGCATCTTTTGTTGTTTTAATGAGTGGGGAAAATTCTGCCAAACCAACGCAGCTTTGG
GAAGAGTGCTCAAGCTGGTATTACTATGTAACTATGCCAATGCCAGCCTCCACCTTCACA
ATTGCAGTGGGATGCTGGACAGAAATGAAGATGGAGACATGGTCATCAAATGATTTGGCA
ACAGAGAGACCCTTCTCACCTTCTGAGGCCAACTTCAGGCATGTTGGTGTTTGCAGTCAC
ATGGAATACCCCTGCCGCTTCCAGAATGCTTCTGCCACCACCCAGGAGATCATTCCTCAT
CGGGTCTTTGCCCCTGTGTGCCTCACGGGTGCCTGCCAAGAGACCCTTCTGCGGCTGATC
CCTCCTTGCCTCTCAGCAGCACATTCTGTTCTGGGAGCACACCCGTTCTCTCGGCTGGAT
GTTCTCATCGTCCCTGCCAACTTTCCAAGTCTGGGGATGGCCAGCCCACACATCATGTTC
CTCTCTCAGAGCATCTTGACAGGAGGGAACCATCTCTGTGGGACCCGCCTCTGCCATGAA
ATTGCCCATGCCTGGTTTGGCCTAGCCATCGGGGCCCGAGACTGGACGGAGGAGTGGCTG
AGTGAAGGCTTCGCCACTCACTTGGAGGATGTGTTTTGGGCCACAGCACAGCAGCTGGCC
CCCTATGAGGCCCGGGAGCAGCAGGAGCTGAGGGCTTGTCTGCGCTGGCGTCGCCTCCAG
GACGAGATGCAATGCTCCCCCGAGGAGATGCAGGTGTTAAGACCCAGTAAAGACAAAACT
GGCCACACAAGTGACTCGGGAGCATCTGTTATCAAGCATGGACTTAATCCGGAGAAGATC
TTCATGCAGGTGCATTATTTAAAGGGCTACTTCCTTCTTCGGTTTCTTGCCAAAAGACTT
GGAGATGAAACCTATTTTTCATTTTTAAGAAAATTTGTGCACACATTTCATGGACAGCTG
ATTCTTTCCCAGGATTTCCTTCAAATGCTACTGGAGAACATTCCAGAAGAAAAAAGGCTT
GAGCTGTCTGTTGAAAACATCTACCAAGACTGGCTTGAGAGTTCCGGAATACCAAAGCCG
CTGCAGAGGGAGCGTCGCGCCGGGGCGGAGTGCGGGCTTGCGCGGCAAGTGCGCGCCGAG
GTCACGAAATGGATTGGAGTGAACCGGAGACCCCGAAAACGGAAGCGCAGGGAGAAGGAA
GAGGTGTTTGAAAAGCTTCTTCCAGACCAGCTGGTCTTGCTTCTGGAGCATCTCTTGGAG
CAGAAGACTCTGAGCCCCCGAACTCTGCAAAGCCTCCAGAGGACATACCACCTCCAGGAT
CAGGATGCAGAGGTTCGCCATCGGTGGTGTGAACTCATTGTTAAGCACAAGTTCACGAAA
GCCTACAAAAGTGTGGAGAGGTTCCTTCAGGAGGATCAGGCCATGGGTGTGTACCTCTAC
GGGGAGCTGATGGTGAGTGAGGACGCCAGACAGCAGCAGCTCGCCCGTAGGTGCTTCGAG
CGGACCAAGGAGCAGATGGATAGGTCCTCAGCCCAGGTGGTGGCCGAAATGTTATTTTAA
Protein Properties
Number of Residues 819
Molecular Weight 93571.6
Theoretical pI 6.13
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Aminopeptidase O
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSI
EEACQSESNKACKFGMPEPCHIPVTNARTFSSEMEYNDFAICSKGEKDTSDKDGNHDNQE
HASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDF
PHAIRIWYKTKPEGRSVTWTSDQSGRPCVYTVGSPINNRALFPCQEPPVAMSTWQATVRA
AASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLI
PPCLSAAHSVLGAHPFSRLDVLIVPANFPSLGMASPHIMFLSQSILTGGNHLCGTRLCHE
IAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQ
DEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRL
GDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKRLELSVENIYQDWLESSGIPKP
LQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKLLPDQLVLLLEHLLE
QKTLSPRTLQSLQRTYHLQDQDAEVRHRWCELIVKHKFTKAYKSVERFLQEDQAMGVYLY
GELMVSEDARQQQLARRCFERTKEQMDRSSAQVVAEMLF
GenBank ID Protein 58737696
UniProtKB/Swiss-Prot ID Q8N6M6
UniProtKB/Swiss-Prot Entry Name AMPO_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ560639
GeneCard ID AOPEP
GenAtlas ID AOPEP
HGNC ID HGNC:1361
References
General References
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  3. Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blocker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I: DNA sequence and analysis of human chromosome 9. Nature. 2004 May 27;429(6990):369-74. [PubMed:15164053 ]
  4. Diaz-Perales A, Quesada V, Sanchez LM, Ugalde AP, Suarez MF, Fueyo A, Lopez-Otin C: Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase. J Biol Chem. 2005 Apr 8;280(14):14310-7. Epub 2005 Feb 1. [PubMed:15687497 ]