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Identification
HMDB Protein ID HMDBP09264
Secondary Accession Numbers
  • 15092
Name E3 ubiquitin-protein ligase MARCH3
Synonyms
  1. MARCH-III
  2. Membrane-associated RING finger protein 3
  3. Membrane-associated RING-CH protein III
  4. RING finger protein 173
Gene Name MARCH3
Protein Type Enzyme
Biological Properties
General Function Involved in zinc ion binding
Specific Function E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
Cellular Location
  1. Multi-pass membrane protein
  2. Multi-pass membrane protein
  3. Cytoplasmic vesicle membrane
  4. Early endosome membrane
Gene Properties
Chromosome Location Chromosome:5
Locus 5q23.2
SNPs MARCH3
Gene Sequence
>762 bp
ATGACAACCAGCCGCTGCAGTCACCTGCCCGAAGTCCTGCCAGACTGCACCAGCTCAGCT
GCACCCGTGGTGAAGACGGTGGAGGATTGTGGCAGCCTAGTGAATGGGCAGCCGCAGTAT
GTCATGCAAGTTTCAGCCAAGGACGGGCAGCTGCTGTCAACAGTAGTGCGGACTCTTGCC
ACCCAGAGCCCCTTCAATGACCAGCCGATGTGCAGGATCTGCCACGAGGGCAGCAGCCAA
GAGGACTTGCTCTCTCCATGTGAATGTACAGGGACCTTGGGGACAATTCATCGGAGCTGC
CTGGAGCACTGGCTGTCATCCTCAAACACCAGCTACTGTGAACTCTGCCACTTCAGGTTT
GCAGTCGAGCGCAAACCCAGGCCGTTAGTGGAGTGGCTGAGAAACCCTGGCCCCCAGCAT
GAGAAGCGGACTCTGTTTGGCGACATGGTGTGCTTCTTGTTTATAACTCCCCTGGCCACC
ATCTCGGGCTGGCTGTGCCTGCGGGGCGCCGTGGACCACCTGCACTTTAGTAGTCGGCTG
GAAGCCGTCGGACTGATTGCACTCACTGTCGCACTCTTCACTATTTACCTCTTTTGGACA
CTAGTGTCATTTAGGTACCACTGTCGATTGTACAACGAGTGGCGTCGGACCAATCAGAGG
GTGATTCTCCTCATTCCAAAGTCTGTCAATGTACCTTCTAACCAGCCGTCCTTGCTGGGC
CTCCATTCGGTCAAGAGGAACTCAAAGGAGACAGTTGTTTGA
Protein Properties
Number of Residues 253
Molecular Weight 28503.7
Theoretical pI 8.26
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 145-165
  • 182-202
Protein Sequence
>E3 ubiquitin-protein ligase MARCH3
MTTSRCSHLPEVLPDCTSSAAPVVKTVEDCGSLVNGQPQYVMQVSAKDGQLLSTVVRTLA
TQSPFNDRPMCRICHEGSSQEDLLSPCECTGTLGTIHRSCLEHWLSSSNTSYCELCHFRF
AVERKPRPLVEWLRNPGPQHEKRTLFGDMVCFLFITPLATISGWLCLRGAVDHLHFSSRL
EAVGLIALTVALFTIYLFWTLVSFRYHCRLYNEWRRTNQRVILLIPKSVNVPSNQPSLLG
LHSVKRNSKETVV
GenBank ID Protein 158261281
UniProtKB/Swiss-Prot ID Q86UD3
UniProtKB/Swiss-Prot Entry Name MARH3_HUMAN
PDB IDs Not Available
GenBank Gene ID AK290129
GeneCard ID MARCH3
GenAtlas ID MARCH3
HGNC ID HGNC:28728
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Fukuda H, Nakamura N, Hirose S: MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II. J Biochem. 2006 Jan;139(1):137-45. [PubMed:16428329 ]