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Identification
HMDB Protein ID HMDBP09266
Secondary Accession Numbers
  • 15094
Name Ubiquitin-conjugating enzyme E2 U
Synonyms
  1. Ubiquitin carrier protein U
  2. Ubiquitin-protein ligase U
Gene Name UBE2U
Protein Type Enzyme
Biological Properties
General Function Involved in acid-amino acid ligase activity
Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity).
Pathways
  • protein ubiquitination
  • Ubiquitin mediated proteolysis
Reactions
Adenosine triphosphate + ubiquitin + protein lysine → Adenosine monophosphate + Pyrophosphate + protein N-ubiquityllysine details
GO Classification
Function
catalytic activity
small conjugating protein ligase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
Molecular Function
ubiquitin-protein ligase activity
ATP binding
Process
metabolic process
regulation of protein metabolic process
macromolecule metabolic process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
post-translational protein modification
macromolecule modification
protein modification process
Cellular Location Not Available
Gene Properties
Chromosome Location 1
Locus 1p31.3
SNPs UBE2U
Gene Sequence
>966 bp
ATGCACGGCAGAGCTTACCTCTTGCTGCACAGAGACTTCTGTGATCTCAAGGAGAACAAT
TATAAGGGTATCACTGCTAAGCCTGTAAGTGAAGATATGATGGAATGGGAAGTTGAAATT
GAAGGTCTACAGAATTCAGTTTGGCAGGGTTTAGTCTTCCAACTGACAATACATTTTACA
TCGGAGTACAACTATGCTCCTCCAGTTGTGAAATTTATAACAATTCCGTTTCATCCAAAT
GTAGACCCACACACTGGTCAGCCCTGTATAGACTTTTTGGACAACCCTGAGAAGTGGAAT
ACAAACTATACATTGAGCAGCATCTTACTTGCCCTACAGGTTATGCTTTCTAATCCAGTG
CTAGAGAATCCAGTGAATTTGGAAGCAGCCAGAATACTGGTTAAAGATGAATCTCTGTAC
AGAACAATTCTAAGACTTTTCAACAGGCCATTACAAATGAAAGATGACAGCCAGGAGTTA
CCTAAAGACCCACGTAAATGTATCAGACCAATTAAAACAACCTCATTTAGTGATTACTAC
CAGACATGGTCCAGAATAGCTACATCAAAAGCCACAGAATACTACAGAACTCCATTGCTC
AAAGTTCCAAATTTCATTGGACAGTATTACAAATGGAAGAAAATGGATCTACAGCATCAG
AAAGAATGGAATTTAAAGTATTCCGTTATCAAGTGTTGGCTTGCTAGAAAAAGAATGCCT
CATGAAGTCACTCACTCAATGGAAGAAATTAAGCTCTGCCCAACTCTAATTCCCACCACA
GATGAAATTTTTCTTGAGTCACCAACTGCAATAAATAGCATCACAGACATTTATGAAACA
GAAGAGGAGGGGTGGAAGAGTGACACTTCATTATATGAAAATGACACAGATGAGCCCAGG
GAAGAGGAAGTGGAAGATCTGATCTCCTGGACCAATACTCTCAATACAAATACTTCAGAA
GATTAA
Protein Properties
Number of Residues 321
Molecular Weight 26688.485
Theoretical pI 7.887
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Ubiquitin-conjugating enzyme E2 U
MHGRAYLLLHRDFCDLKENNYKGITAKPVSEDMMEWEVEIEGLQNSVWQGLVFQLTIHFT
SEYNYAPPVVKFITIPFHPNVDPHTGQPCIDFLDNPEKWNTNYTLSSILLALQVMLSNPV
LENPVNLEAARILVKDESLYRTILRLFNRPLQMKDDSQELPKDPRKCIRPIKTTSFSDYY
QTWSRIATSKATEYYRTPLLKVPNFIGQYYKWKKMDLQHQKEWNLKYSVIKCWLARKRMP
HEVTHSMEEIKLCPTLIPTTDEIFLESPTAINSITDIYETEEEGWKSDTSLYENDTDEPR
EEEVEDLISWTNTLNTNTSED
GenBank ID Protein 56205233
UniProtKB/Swiss-Prot ID Q5VVX9
UniProtKB/Swiss-Prot Entry Name UBE2U_HUMAN
PDB IDs
GenBank Gene ID AL161916
GeneCard ID UBE2U
GenAtlas ID UBE2U
HGNC ID HGNC:28559
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. [PubMed:16710414 ]