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Identification
HMDB Protein ID HMDBP09267
Secondary Accession Numbers
  • 15095
Name Probable E3 ubiquitin-protein ligase MARCH10
Synonyms
  1. MARCH-X
  2. Membrane-associated RING finger protein 10
  3. Membrane-associated RING-CH protein X
  4. RING finger protein 190
Gene Name MARCH10
Protein Type Enzyme
Biological Properties
General Function Involved in zinc ion binding
Specific Function E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 17q23.2
SNPs MARCH10
Gene Sequence
>2427 bp
ATGTTGCATGACGCAAGGGACAGGCAGAAGTTCTTCAGCGATGTTCAGTATCTGCGGGAC
ATGCAGCATAAGGTGGACTCTGAGTATCAGGCTTGTCTGAGACGACAGGAATATAGAAGA
GACCCAAATGAGAAGAAACGCGATCAGTTTTGGGGGCAAGAGACAAGTTTTGAGAGATCC
CGGTTTTCTAGCAGGTCATCTTCCAAACAGAGTTCTAGTGAGGAGGATGCTCTAACTGAA
CCAAGGTCATCTATCAAGATATCTGCATTTAAGTGTGACTCCAAACTTCCAGCAATTGAC
CAAACATCAGTCAAGCAGAAACATAAAAGTACCATGACTGTAAGGAAAGCAGAGAAAGTG
GACCCCAGCGAACCCTCTCCAGCAGACCAAGCACCAATGGTTTTATTAAGAAAGAGGAAG
CCAAACCTGAGGAGATTTACAGTCAGCCCAGAATCGCACAGCCCGAGAGCATCTGGGGAC
AGAAGCAGACAGAAACAGCAGTGGCCTGCAAAGGTGCCGGTTCCCAGGGGAGCAGATCAA
GTAGTTCAACAAGAAGGCCTGATGTGTAACACTAAGCTGAAGAGGCCAAATCAAGAGAGA
AGAAACTTGGTCCCATCGTCACAGCCAATGACTGAGAACGCCCCTGATAGAGCCAAAAAA
GGAGACCCGAGTGCTCCTTCCCAGAGTGAGCTGCATCCAGCCCTGTCCCAGGCCTTCCAA
GGAAAAAATAGTCCTCAAGTATTGAGTGAGTTCTCGGGGCCACCACTCACACCCACCACT
GTAGGAGGGCCAAGAAAGGCATCATTTAGGTTCCGAGATGAAGACTTTTATTCCATTTTG
TCATTGAACAGCAGAAGAGAAAGCGATGACACTGAAGAGGAAACCCAGTCTGAAGAATGT
CTGTGGGTTGGTGTGCGCTCACCCTGTTCTCCTTCCCATCACAAAAGAAGTAGATTTGGG
GGGACATCGACCCCTCAGGCCAAAAATAAAAATTTTGAAGAAAATGCTGAAAATTGCAGA
GGTCATTCTTCAAGAAGAAGTGAGCCCAGTCATGGCTCATTGAGAATAAGCAATGCAATG
GAGCCAGCAACAGAGCGGCCTTCTGCTGGGCAAAGGTTGTCCCAAGACCCCGGGCTGCCT
GATAGGGAATCTGCTACAGAGAAGGACAGAGGTGGCAGTGAAAATGCGAAAAAGAGCCCT
CTTTCGTGGGACACCAAATCCGAGCCCAGACAAGAGGTTGGTGTCAATGCTGAAAATGTA
TGGAGTGATTGTATTTCTGTGGAACATAGGCCTGGCACCCATGATTCTGAAGGATACTGG
AAAGACTATTTAAACAGTTCTCAAAATTCTCTTGACTACTTTATTTCTGGCAGACCAATA
TCTCCAAGATCATCAGTGAATTCATCCTATAACCCTCCTGCATCATTCATGCATTCTGCT
CTGAGAGATGATATTCCAGTAGACTTGTCAATGTCATCGACTTCAGTTCACAGCTCAGAC
TCAGAGGGAAACTCAGGGTTTCATGTTTGCCAACCACTGTCTCCCATTAGAAATAGGACT
CCATTTGCCAGTGCCGAAAACCATAATTATTTCCCAGTAAACAGTGCACACGAATTTGCT
GTCAGGGAAGCAGAAGATACTACTTTAACAAGCCAGCCTCAGGGGGCTCCACTATATACA
GATCTCTTACTAAATCCACAGGGCAATTTGTCCTTAGTGGATTCTTCCAGCTCCTCTCCA
TCAAGAATGAACTCAGAAGGCCATTTGCATGTGTCTGGGTCTCTGCAAGAAAATACACCA
TTTACTTTCTTTGCAGTGTCTCATTTCCCAAATCAAAATGATAATGGGAGCAGGATGGCA
GCCTCTGGTTTCACAGATGAAAAGGAAACCAGTAAGATAAAGGCAGACCCTGAGAAACTC
AAGAAATTGCAAGAAAGTCTCCTGGAGGAGGACTCCGAGGAGGAGGGAGACTTGTGTCGC
ATCTGTCAGATAGCCGGGGGTTCCCCAAGCAACCCCCTCCTGGAGCCTTGCGGCTGTGTG
GGAAGCCTGCAGTTTGTTCATCAAGAGTGCCTGAAAAAGTGGCTGAAAGTGAAAATAACA
TCAGGAGCAGATCTTGGTGCCGTGAAGACCTGTGAGATGTGTAAGCAAGGCCTGCTGGTT
GACCTGGGTGACTTTAACATGATTGAGTTCTACCAGAAGCACCAGCAATCTCAGGCACAA
AACGAGCTGATGAATTCAGGCTTGTACCTGGTGCTGCTGCTTCACCTCTATGAGCAGAGG
TTTGCAGAACTCATGAGGCTCAACCACAACCAGGTGGAAAGAGAGAGGTTGTCAAGAAAT
TACCCACAACCCAGAACAGAGGAAAATGAAAATTCGGAGTTGGGAGATGGAAATGAAGGC
AGCATTTCTCAAAGCCAGGTCGTCTAG
Protein Properties
Number of Residues 808
Molecular Weight 90510.2
Theoretical pI 6.69
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Probable E3 ubiquitin-protein ligase MARCH10
MLHDARDRQKFFSDVQYLRDMQHKVDSEYQACLRRQEYRRDPNEKKRDQFWGQETSFERS
RFSSRSSSKQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKV
DPSEPSPADQAPMVLLRKRKPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQ
VVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSELHPALSQAFQ
GKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEEC
LWVGVRSPCSPSHHKRSRFGGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAM
EPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPRQEVGVNAENV
WSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSA
LRDDIPVDLSMSSTSVHSSDSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFA
VREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLHVSGSLQENTP
FTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCR
ICQIAGGSPSNPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLV
DLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNHNQVERERLSRN
YPQPRTEENENSELGDGNEGSISQSQVV
GenBank ID Protein 154937342
UniProtKB/Swiss-Prot ID Q8NA82
UniProtKB/Swiss-Prot Entry Name MARHA_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001100875.1
GeneCard ID MARCH10
GenAtlas ID MARCH10
HGNC ID HGNC:26655
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  4. Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature. 2006 Apr 20;440(7087):1045-9. [PubMed:16625196 ]