Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP09287
Secondary Accession Numbers
  • 15116
Name E3 ubiquitin-protein ligase TRIM33
Synonyms
  1. Ectodermin homolog
  2. Protein Rfg7
  3. RET-fused gene 7 protein
  4. TIF1-gamma
  5. Transcription intermediary factor 1-gamma
  6. Tripartite motif-containing protein 33
Gene Name TRIM33
Protein Type Enzyme
Biological Properties
General Function Involved in zinc ion binding
Specific Function Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade)
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
protein binding
Cellular Location
  1. Nucleus
Gene Properties
Chromosome Location Chromosome:1
Locus 1p13.1
SNPs TRIM33
Gene Sequence
>3384 bp
ATGGCGGAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCG
CCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAGGAGGCGGAGCCGCCTCTCACCGCG
GTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCC
GGGCCCGACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCT
CCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGCGCAGTATCGACGCCGGCTCCAGCT
CCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCG
CTCCTGGACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCC
AAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGCTGCCTGCCCGAGCCGGAGCGCCAG
CTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGG
TGCCCAGTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAA
GACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAATCAGAACAGGTATGTACTAGTTGT
GAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACA
TGTATCGAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAA
GATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGCCCTGTTTTCTGCCCTGTACACAAA
CAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAG
CTATTGGAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAG
GGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAGAAGAAGAATTATGTTCATTTTGCA
GCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAG
GAAATTAAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTC
TTACAACAGCTAGAGAATGTTACAAAGGAAAGACAGATGAAGTTACTACAGCAGCAGAAT
GACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATT
GCAAGTGGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGT
CATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCTGCTAATGGAGCAATACGTTTCCAT
TGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGT
AAACCAGCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAAC
CACATTAGTAAAACCCCTGGACAGATTAACTTAGCACAGCTTCGACTCCAGCACATGCAA
CAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCA
GCACCTGTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAG
ATGTTACAACAACAGCCTCCTCGATTGATCAGTGTGCAAACAATGCAAAGAGGCAACATG
AACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCA
GGGATACCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAA
CACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTAGTATCGGTACACAACACCACAATC
AACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCA
TCTGTTACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTG
CCAGATATTCCACCCATACAGTTGGAAGATGCTGGCTCAAGTAGTTTAGATAATCTACTA
AGTAGATACATCTCAGGCAGTCACCTACCCCCACAGCCTACAAGCACCATGAATCCTTCT
CCAGGTCCCTCTGCCCTTTCTCCGGGATCATCAGGTTTATCCAATTCTCACACACCTGTG
AGACCCCCAAGTACTTCTAGTACTGGCAGTCGAGGCAGCTGTGGGTCATCAGGAAGAACT
GCTGAGAAGACAAGTCTTAGTTTCAAATCTGATCAGGTGAAGGTCAAGCAAGAACCTGGG
ACTGAAGATGAAATATGTAGCTTTTCAGGAGGTGTAAAACAAGAAAAAACAGAGGATGGC
AGGAGGAGTGCTTGCATGTTGAGCAGTCCTGAGAGTAGCTTGACACCACCTCTCTCAACC
AACCTGCATCTAGAAAGTGAATTGGATGCATTGGCAAGCCTGGAAAACCATGTGAAAATT
GAACCTGCAGATATGAATGAAAGCTGCAAACAGTCAGGGCTCAGCAGCCTTGTTAATGGA
AAGTCCCCAATTCGAAGCCTCATGCACAGGTCGGCAAGGATTGGAGGAGATGGCAACAAT
AAAGATGATGACCCAAATGAAGACTGGTGTGCTGTCTGCCAAAACGGAGGAGATCTCTTG
TGCTGCGAAAAATGTCCAAAGGTCTTTCATCTAACTTGTCATGTTCCAACACTACTTAGC
TTTCCAAGTGGGGACTGGATATGCACATTTTGTAGAGATATTGGAAAGCCAGAAGTTGAA
TATGATTGTGATAATTTGCAACATAGTAAGAAGGGGAAAACTGCGCAGGGGTTAAGCCCC
GTGGACCAAAGGAAATGTGAACGTCTTCTGCTTTACCTCTATTGCCATGAATTAAGTATT
GAATTCCAGGAGCCTGTTCCTGCTTCGATACCAAACTACTATAAAATTATAAAGAAACCA
ATGGATTTATCCACCGTGAAAAAGAAGCTTCAGAAAAAACATTCCCAACACTACCAAATC
CCGGATGACTTTGTGGCCGATGTCCGTTTGATCTTCAAGAACTGTGAAAGGTTTAATGAA
ATGATGAAAGTTGTTCAAGTTTATGCAGACACACAAGAGATTAATTTGAAGGCTGATTCA
GAAGTAGCTCAGGCAGGGAAAGCAGTTGCATTGTACTTTGAAGATAAACTCACAGAGATC
TACTCAGACAGGACCTTCGCACCTTTGCCAGAGTTTGAGCAGGAAGAGGATGATGGTGAG
GTAACTGAGGACTCTGATGAAGACTTTATACAGCCCCGCAGAAAACGCCTAAAGTCAGAT
GAGAGACCAGTACATATAAAGTAA
Protein Properties
Number of Residues 1127
Molecular Weight 122520.2
Theoretical pI 6.65
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>E3 ubiquitin-protein ligase TRIM33
MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP
SVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPS
PGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPG
TEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKT
EPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLL
CCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSP
VDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQI
PDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEI
YSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
GenBank ID Protein 74027249
UniProtKB/Swiss-Prot ID Q9UPN9
UniProtKB/Swiss-Prot Entry Name TRI33_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_015906.3
GeneCard ID TRIM33
GenAtlas ID TRIM33
HGNC ID HGNC:16290
References
General References
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