Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP09329
Secondary Accession Numbers
  • 15166
Name E3 ubiquitin-protein ligase DZIP3
Synonyms
  1. DAZ-interacting protein 3
  2. RNA-binding ubiquitin ligase of 138 kDa
  3. hRUL138
Gene Name DZIP3
Protein Type Enzyme
Biological Properties
General Function Involved in protein binding
Specific Function E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA
Pathways
  • Pyruvate metabolism
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
protein binding
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location Chromosome:3
Locus 3q13.13
SNPs DZIP3
Gene Sequence
>3627 bp
ATGGATTCTCTACCAGATGAATTTTTTGTGAGGCATCCTGCTGTGGAGGATCAGAGGAAG
GAAGAAACTGAGAATAAGCTAGAAAAATCATCTGGTCAACTGAACAAACAGGAAAATGAC
ATACCTACTGATCTTGTCCCTGTTAACCTACTATTAGAAGTGAAGAAGTTATTAAATGCA
ATTAATACTCTACCAAAAGGTGTGGTTCCTCACATTAAGAAGTTCTTACAAGAAGATTTT
TCCTTCCAAACTATGCAGAGAGAAGTTGCAGCTAACAGCCAGAATGGTGAGGAAATTGTT
CCTGCTTTGACTTTACGTTTCTTGATTACACAGCTAGAAGCAGCACTTAGGAACATTCAA
GCTGGCAATTATACCGCACACCAGATTAATATTGGTTATTATTTGACATTACTGTTTTTA
TATGGAGTAGCACTCACTGAAAGAGGAAAGAAAGAGGATTATACAGAAGCTGAGAATAAA
TTTCTGGTGATGAAGATGATGATCCAAGAAAATGAAATTTGTGAAAACTTTATGTCTTTA
GTTTATTTTGGACGTGGTTTACTGCGATGTGCTCAAAAGAGATATAATGGAGGACTGCTA
GAATTTCATAAAAGCTTACAAGAAATTGGAGACAAAAATGACCATTGGTTTGACATAGAT
CCTACAGAAGATGAAGATTTACCTACAACTTTTAAAGATCTTCTTAATAATTTTATCAAG
ACAACTGAAAGCAATATAATGAAGCAGACGATTTGTAGTTACCTAGATTGTGAACGATCT
TGTGAAGCTGACATTTTGAAGAACACCAGTTATAAGGGATTTTTTCAGTTAATGTGCAGT
AAAAGTTGCTGTGTTTATTTCCATAAAATTTGCTGGAAAAAGTTCAAGAATTTAAAGTAT
CCAGGTGAAAATGATCAGAGTTTTAGTGGGAAAAAATGTTTGAAGGAAGGATGTACAGGT
GACATGGTAAGGATGCTGCAATGTGATGTACCTGGAATTGTTAAAATTTTGTTTGAAGTT
GTGAGAAAGGATGAATATATCACCATTGAAAATTTAGGAGCAAGTTATAGAAAGTTGATA
TCTCTGAAAATAACTGATACTGATATAAGACCGAAGATCAGTTTAAAATTTAATACAAAA
GATGAAATGCCTATCTTCAAGCTTGATTATAATTATTTCTATCATCTGCTTCATATAATT
ATTATTTCTGGTACTGACATTGTTCGACAAATATTTGATGAGGCTATGCCACCTCCTCTT
TTGAAAAAAGAGCTTCTTATACACAAGAATGTGCTGGAATCCTACTACAACCATCTTTGG
ACCAATCATCCTTTGGGTGGATCATGGCATCTGCTTTATCCTCCTAACAAGGAGTTACCG
CAATCCAAACAGTTTGACTTATGCCTCCTGTTAGCTCTTATAAAACATTTAAATGTGTTC
CCTGCACCCAAAAAAGGATGGAATATGGAACCGCCATCTTCTGACATCTCTAAATCTGCA
GACATCCTGAGACTGTGCAAATACAGGGATATCCTCCTTAGTGAGATTTTGATGAATGGT
CTCACTGAGTCACAGTTCAATTCAATTTGGAAAAAAGTTTCAGATATTCTTCTGCGCCTT
GGGATGATGCAAGAGGATATTGACAAAGTGAAGGAGAATCCCATTGAGAATATCTCCCTT
GATTACCATCAGCTATCTGTCTACCTAGGCATACCAGTACCAGAAATCATACAGAGGATG
TTATCCTGCTATCAACAAGGAATTGCTCTACAGTCAATAACAGGCAGTCAGCGTATTGAA
ATAGAAGAGTTACAGAATGAGGAAGAAGAACTAAGTCCACCTCTCATGGAGTACAATATA
AATGTGAAATCACACCCTGAGATACAGTTTGCAGAAATTAATAAAGATGGGACCTCAATA
CCCAGTGAATCTTCAACAGAATCTCTTAAAGATCTCCAGGAAGTTAAGAGTAAACAAAGG
AAAAAGAAGAAGACTAAGAATAAAAAGAATAAAGACTCAAAAGAAGACCAAGTCCCATAT
GTGGTAGAAAAGGAAGAGCAGTTGAGGAAAGAACAAGCAAATCCACACTCAGTCAGTAGA
CTTATAAAAGATGATGCAAGTGATGTTCAAGAGGATTCTGCAATGGAAGACAAGTTCTAT
AGCCTGGATGAATTGCATATTCTGGACATGATAGAGCAGGGCTCAGCTGGCAAAGTAACT
ACAGACTATGGAGAAACTGAAAAGGAAAGGCTTGCTCGTCAAAGGCAGCTTTATAAATTG
CACTATCAGTGTGAAGATTTCAAAAGACAGTTGAGAACAGTGACTTTTCGGTGGCAAGAA
AACCAAATGCAGATTAAAAAGAAAGACAAAATTATCGCATCTCTTAATCAACAAGTTGCT
TTTGGAATCAATAAGGTTTCCAAATTACAGCGTCAAATCCATGCTAAAGATAATGAAATC
AAGAACCTTAAAGAGCAACTTTCTATGAAAAGATCTCAGTGGGAAATGGAAAAACATAAT
CTGGAAAGCACAATGAAAACATACGTAAGCAAACTGAACGCAGAAACTAGCAGAGCTTTA
ACAGCCGAGGTGTATTTCTTACAGTGTCGTAGGGATTTTGGTTTGCTTCATCTAGAGCAG
ACTGAAAAGGAATGTCTCAATCAGCTTGCCAGGGTGACTCACATGGCAGCAAGCAACCTA
GAATCACTTCAATTAAAGGCTGCGGTAGACAGTTGGAATGCCATTGTGGCAGATGTTAGA
AACAAGATTGCATTCCTCAGGACACAGTACAATGAACAAATAAACAAAGTCAAGCAAGGA
TTTGCCTTGAGTACCTTGCCTCCAGTCCAGCTTCCTCCTCCACCACCCAGTCCTGAGATA
CTGATGCAGCAGTTCTTAGGAAGACCCCTTGTGAAAGAATCTTTCTTTAGACCCATACTT
ACTGTTCCTCAAATGCCTGCAGTTTGCCCGGGAGTCGTCTCTGCAACTGGCCAACCTAGA
GCCCCCCTGATGACTGGCATAGCCTGGGCTCTGCCAGCGCCTGTGGGAGACGCTGTGCCT
CCCAGTGCAGGTCTGCGGAGTGATCCCTCCATCATGAATTGGGAGAGAATTACAGACAGG
CTGAAAACTGCCTTTCCACAGCAAACCAGAAAGGAACTTACAGATTTCTTACGGAAATTG
AAGGATGCTTATGGAAAATCCTTGTCTGAACTGACATTTGATGAAATTGTTTGCAAGATT
TCCCAGTTTATTGACCCCAAAAAGTCTCAGAGTCAAGGAAAATCAGTGTCAAATGTTAAT
TGTGTTTCACCTAGTCATTCTCCATCACAGCCTGATGCTGCCCAGCCCCCAAAACCAGCC
TGGAGGCCACTCACTTCACAGGGTCCTGCCACATGGGAAGGAGCCAGTAATCCAGATGAG
GAAGAGGAAGAAGAAGAGCCTTGTGTGATCTGTCATGAGAATCTGTCTCCAGAAAATCTT
TCAGTTTTGCCTTGCGCTCACAAATTCCATGCTCAGTGCATTAGACCATGGTTGATGCAA
CAGGGGACATGTCCAACGTGCAGACTCCACGTTTTGCTACCAGAAGAATTCCCTGGTCAC
CCCAGCCGGCAGTTGCCCAAGATCTGA
Protein Properties
Number of Residues 1208
Molecular Weight 138603.1
Theoretical pI 6.87
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>E3 ubiquitin-protein ligase DZIP3
MDSLPDEFFVRHPAVEDQRKEETENKLEKSSGQLNKQENDIPTDLVPVNLLLEVKKLLNA
INTLPKGVVPHIKKFLQEDFSFQTMQREVAANSQNGEEIVPALTLRFLITQLEAALRNIQ
AGNYTAHQINIGYYLTLLFLYGVALTERGKKEDYTEAENKFLVMKMMIQENEICENFMSL
VYFGRGLLRCAQKRYNGGLLEFHKSLQEIGDKNDHWFDIDPTEDEDLPTTFKDLLNNFIK
TTESNIMKQTICSYLDCERSCEADILKNTSYKGFFQLMCSKSCCVYFHKICWKKFKNLKY
PGENDQSFSGKKCLKEGCTGDMVRMLQCDVPGIVKILFEVVRKDEYITIENLGASYRKLI
SLKITDTDIRPKISLKFNTKDEMPIFKLDYNYFYHLLHIIIISGTDIVRQIFDEAMPPPL
LKKELLIHKNVLESYYNHLWTNHPLGGSWHLLYPPNKELPQSKQFDLCLLLALIKHLNVF
PAPKKGWNMEPPSSDISKSADILRLCKYRDILLSEILMNGLTESQFNSIWKKVSDILLRL
GMMQEDIDKVKENPIENISLDYHQLSVYLGIPVPEIIQRMLSCYQQGIALQSITGSQRIE
IEELQNEEEELSPPLMEYNINVKSHPEIQFAEINKDGTSIPSESSTESLKDLQEVKSKQR
KKKKTKNKKNKDSKEDQVPYVVEKEEQLRKEQANPHSVSRLIKDDASDVQEDSAMEDKFY
SLDELHILDMIEQGSAGKVTTDYGETEKERLARQRQLYKLHYQCEDFKRQLRTVTFRWQE
NQMQIKKKDKIIASLNQQVAFGINKVSKLQRQIHAKDNEIKNLKEQLSMKRSQWEMEKHN
LESTMKTYVSKLNAETSRALTAEVYFLQCRRDFGLLHLEQTEKECLNQLARVTHMAASNL
ESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEI
LMQQFLGRPLVKESFFRPILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVP
PSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSLSELTFDEIVCKI
SQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDE
EEEEEEPCVICHENLSPENLSVLPCAHKFHAQCIRPWLMQQGTCPTCRLHVLLPEEFPGH
PSRQLPKI
GenBank ID Protein 7662244
UniProtKB/Swiss-Prot ID Q86Y13
UniProtKB/Swiss-Prot Entry Name DZIP3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_014648.3
GeneCard ID DZIP3
GenAtlas ID DZIP3
HGNC ID HGNC:30938
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Jun 30;5(3):169-76. [PubMed:9734811 ]
  4. Kreft SG, Nassal M: hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase. J Cell Sci. 2003 Feb 15;116(Pt 4):605-16. [PubMed:12538761 ]
  5. Moore FL, Jaruzelska J, Fox MS, Urano J, Firpo MT, Turek PJ, Dorfman DM, Pera RA: Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):538-43. Epub 2003 Jan 2. [PubMed:12511597 ]