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Identification
HMDB Protein ID HMDBP09433
Secondary Accession Numbers
  • 15312
Name Bone morphogenetic protein 1
Synonyms
  1. BMP-1
  2. Mammalian tolloid protein
  3. PCP
  4. Procollagen C-proteinase
  5. mTld
Gene Name BMP1
Protein Type Enzyme
Biological Properties
General Function Involved in calcium ion binding
Specific Function Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD)
Pathways Not Available
Reactions Not Available
GO Classification
Function
endopeptidase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
transition metal ion binding
zinc ion binding
metalloendopeptidase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
metallopeptidase activity
calcium ion binding
Process
metabolic process
macromolecule metabolic process
protein metabolic process
proteolysis
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:8
Locus 8p21.3
SNPs BMP1
Gene Sequence
>2961 bp
ATGCCCGGCGTGGCCCGCCTGCCGCTGCTGCTCGGGCTGCTGCTGCTCCCGCGTCCCGGC
CGGCCGCTGGACTTGGCCGACTACACCTATGACCTGGCGGAGGAGGACGACTCGGAGCCC
CTCAACTACAAAGACCCCTGCAAGGCGGCTGCCTTTCTTGGGGACATTGCCCTGGACGAA
GAGGACCTGAGGGCCTTCCAGGTACAGCAGGCTGTGGATCTCAGACGGCACACAGCTCGT
AAGTCCTCCATCAAAGCTGCAGTTCCAGGAAACACTTCTACCCCCAGCTGCCAGAGCACC
AACGGGCAGCCTCAGAGGGGAGCCTGTGGGAGATGGAGAGGTAGATCCCGTAGCCGGCGG
GCGGCGACGTCCCGACCAGAGCGTGTGTGGCCCGATGGGGTCATCCCCTTTGTCATTGGG
GGAAACTTCACTGGTAGCCAGAGGGCAGTCTTCCGGCAGGCCATGAGGCACTGGGAGAAG
CACACCTGTGTCACCTTCCTGGAGCGCACTGACGAGGACAGCTATATTGTGTTCACCTAT
CGACCTTGCGGGTGCTGCTCCTACGTGGGTCGCCGCGGCGGGGGCCCCCAGGCCATCTCC
ATCGGCAAGAACTGTGACAAGTTCGGCATTGTGGTCCACGAGCTGGGCCACGTCGTCGGC
TTCTGGCACGAACACACTCGGCCAGACCGGGACCGCCACGTTTCCATCGTTCGTGAGAAC
ATCCAGCCAGGGCAGGAGTATAACTTCCTGAAGATGGAGCCTCAGGAGGTGGAGTCCCTG
GGGGAGACCTATGACTTCGACAGCATCATGCATTACGCTCGGAACACATTCTCCAGGGGC
ATCTTCCTGGATACCATTGTCCCCAAGTATGAGGTGAACGGGGTGAAACCTCCCATTGGC
CAAAGGACACGGCTCAGCAAGGGGGACATTGCCCAAGCCCGCAAGCTTTACAAGTGCCCA
GCCTGTGGAGAGACCCTGCAAGACAGCACAGGCAACTTCTCCTCCCCTGAATACCCCAAT
GGCTACTCTGCTCACATGCACTGCGTGTGGCGCATCTCTGTCACACCCGGGGAGAAGATC
ATCCTGAACTTCACGTCCCTGGACCTGTACCGCAGCCGCCTGTGCTGGTACGACTATGTG
GAGGTCCGAGATGGCTTCTGGAGGAAGGCGCCCCTCCGAGGCCGCTTCTGCGGGTCCAAA
CTCCCTGAGCCTATCGTCTCCACTGACAGCCGCCTCTGGGTTGAATTCCGCAGCAGCAGC
AATTGGGTTGGAAAGGGCTTCTTTGCAGTCTACGAAGCCATCTGCGGGGGTGATGTGAAA
AAGGACTATGGCCACATTCAATCGCCCAACTACCCAGACGATTACCGGCCCAGCAAAGTC
TGCATCTGGCGGATCCAGGTGTCTGAGGGCTTCCACGTGGGCCTCACATTCCAGTCCTTT
GAGATTGAGCGCCACGACAGCTGTGCCTACGACTATCTGGAGGTGCGCGACGGGCACAGT
GAGAGCAGCACCCTCATCGGGCGCTACTGTGGCTATGAGAAGCCTGATGACATCAAGAGC
ACGTCCAGCCGCCTCTGGCTCAAGTTCGTCTCTGACGGGTCCATTAACAAAGCGGGCTTT
GCCGTCAACTTTTTCAAAGAGGTGGACGAGTGCTCTCGGCCCAACCGCGGGGGCTGTGAG
CAGCGGTGCCTCAACACCCTGGGCAGCTACAAGTGCAGCTGTGACCCCGGGTACGAGCTG
GCCCCAGACAAGCGCCGCTGTGAGGCTGCTTGTGGCGGATTCCTCACCAAGCTCAACGGC
TCCATCACCAGCCCGGGCTGGCCCAAGGAGTACCCCCCCAACAAGAACTGCATCTGGCAG
CTGGTGGCCCCCACCCAGTACCGCATCTCCCTGCAGTTTGACTTCTTTGAGACAGAGGGC
AATGATGTGTGCAAGTACGACTTCGTGGAGGTGCGCAGTGGACTCACAGCTGACTCCAAG
CTGCATGGCAAGTTCTGTGGTTCTGAGAAGCCCGAGGTCATCACCTCCCAGTACAACAAC
ATGCGCGTGGAGTTCAAGTCCGACAACACCGTGTCCAAAAAGGGCTTCAAGGCCCACTTC
TTCTCAGACAAGGACGAGTGCTCCAAGGATAACGGCGGCTGCCAGCAGGACTGCGTCAAC
ACGTTCGGCAGTTATGAGTGCCAATGCCGCAGTGGCTTCGTCCTCCATGACAACAAGCAC
GACTGCAAAGAAGCCGGCTGTGACCACAAGGTGACATCCACCAGTGGTACCATCACCAGC
CCCAACTGGCCTGACAAGTATCCCAGCAAGAAGGAGTGCACGTGGGCCATCTCCAGCACC
CCCGGGCACCGGGTCAAGCTGACCTTCATGGAGATGGACATCGAGTCCCAGCCTGAGTGT
GCCTACGACCACCTAGAGGTGTTCGACGGGCGAGACGCCAAGGCCCCCGTCCTCGGCCGC
TTCTGTGGGAGCAAGAAGCCCGAGCCCGTCCTGGCCACAGGCAGCCGCATGTTCCTGCGC
TTCTACTCAGATAACTCGGTCCAGCGAAAGGGCTTCCAGGCCTCCCACGCCACAGAGTGC
GGGGGCCAGGTACGGGCAGACGTGAAGACCAAGGACCTTTACTCCCACGCCCAGTTTGGC
GACAACAACTACCCTGGGGGTGTGGACTGTGAGTGGGTCATTGTGGCCGAGGAAGGCTAC
GGCGTGGAGCTCGTGTTCCAGACCTTTGAGGTGGAGGAGGAGACCGACTGCGGCTATGAC
TACATGGAGCTCTTCGACGGCTACGACAGCACAGCCCCCAGGCTGGGGCGCTACTGTGGC
TCAGGGCCTCCTGAGGAGGTGTACTCGGCGGGAGATTCTGTCCTGGTGAAGTTCCACTCG
GATGACACCATCACCAAAAAAGGTTTCCACCTGCGATACACCAGCACCAAGTTCCAGGAC
ACACTCCACAGCAGGAAGTGA
Protein Properties
Number of Residues 986
Molecular Weight 111247.8
Theoretical pI 6.89
Pfam Domain Function
Signals
  • 1-22
Transmembrane Regions
  • None
Protein Sequence
>Bone morphogenetic protein 1
MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR
AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVN
TFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISST
PGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLR
FYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGY
GVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHS
DDTITKKGFHLRYTSTKFQDTLHSRK
GenBank ID Protein 5453579
UniProtKB/Swiss-Prot ID P13497
UniProtKB/Swiss-Prot Entry Name BMP1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_006129.4
GeneCard ID BMP1
GenAtlas ID BMP1
HGNC ID HGNC:1067
References
General References
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  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  4. Hillman RT, Green RE, Brenner SE: An unappreciated role for RNA surveillance. Genome Biol. 2004;5(2):R8. Epub 2004 Feb 2. [PubMed:14759258 ]
  5. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA: Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34. [PubMed:3201241 ]
  6. Li SW, Sieron AL, Fertala A, Hojima Y, Arnold WV, Prockop DJ: The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1. Proc Natl Acad Sci U S A. 1996 May 14;93(10):5127-30. [PubMed:8643539 ]
  7. Janitz M, Heiser V, Bottcher U, Landt O, Lauster R: Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1. J Mol Med (Berl). 1998 Feb;76(2):141-6. [PubMed:9500680 ]
  8. Takahara K, Lyons GE, Greenspan DS: Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues. J Biol Chem. 1994 Dec 23;269(51):32572-8. [PubMed:7798260 ]
  9. Garrigue-Antar L, Barker C, Kadler KE: Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity. J Biol Chem. 2001 Jul 13;276(28):26237-42. Epub 2001 Mar 29. [PubMed:11283002 ]