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Showing Protein G protein-coupled receptor kinase 7 (HMDBP09511)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 metabolites
Identification
HMDB Protein ID HMDBP09511
Secondary Accession Numbers
  • 15410
Name G protein-coupled receptor kinase 7
Synonyms
  1. G protein-coupled receptor kinase GRK7
Gene Name GRK7
Protein Type Enzyme
Biological Properties
General Function Involved in protein serine/threonine kinase activity
Specific Function Phosphorylates cone opsins thereby initiating their deactivation
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
g-protein coupled receptor kinase activity
molecular transducer activity
signal transducer activity
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
biological regulation
regulation of biological process
cellular metabolic process
regulation of cellular process
signal transduction
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Lipid-anchor
  2. Membrane
Gene Properties
Chromosome Location Chromosome:3
Locus 3q24
SNPs GRK7
Gene Sequence 
>1662 bp
ATGGTGGACATGGGGGCCCTGGACAACCTGATCGCCAACACCGCCTACCTGCAGGCCCGG
AAGCCCTCGGACTGCGACAGCAAAGAGCTGCAGCGGCGGCGGCGTAGCCTGGCCCTGCCC
GGGCTGCAGGGCTGCGCGGAGCTCCGCCAGAAGCTGTCCCTGAACTTCCACAGCCTGTGT
GAGCAGCAGCCCATCGGTCGCCGCCTCTTCCGTGACTTCCTAGCCACAGTGCCCACGTTC
CGCAAGGCGGCAACCTTCCTAGAGGACGTGCAGAACTGGGAGCTGGCCGAGGAGGGACCC
ACCAAAGACAGCGCGCTGCAGGGGCTGGTGGCCACTTGTGCGAGTGCCCCTGCCCCGGGG
AACCCGCAACCCTTCCTCAGCCAGGCCGTGGCCACCAAGTGCCAAGCAGCCACCACTGAG
GAAGAGCGAGTGGCTGCAGTGACGCTGGCCAAGGCTGAGGCCATGGCTTTCTTGCAAGAG
CAGCCCTTTAAGGATTTCGTGACCAGCGCCTTCTACGACAAGTTTCTGCAGTGGAAACTC
TTCGAGATGCAACCAGTGTCAGACAAGTACTTCACTGAGTTCAGAGTGCTGGGGAAAGGT
GGTTTTGGGGAGGTATGTGCCGTCCAGGTGAAAAACACTGGGAAGATGTATGCCTGTAAG
AAACTGGACAAGAAGCGGCTGAAGAAGAAAGGTGGCGAGAAGATGGCTCTCTTGGAAAAG
GAAATCTTGGAGAAGGTCAGCAGCCCTTTCATTGTCTCTCTGGCCTATGCCTTTGAGAGC
AAGACCCATCTCTGCCTTGTCATGAGCCTGATGAATGGGGGAGACCTCAAGTTCCACATC
TACAACGTGGGCACGCGTGGCCTGGACATGAGCCGGGTGATCTTTTACTCGGCCCAGATA
GCCTGTGGGATGCTGCACCTCCATGAACTCGGCATCGTCTATCGGGACATGAAGCCTGAG
AATGTGCTTCTGGATGACCTCGGCAACTGCAGGTTATCTGACCTGGGGCTGGCCGTGGAG
ATGAAGGGTGGCAAGCCCATCACCCAGAGGGCTGGAACCAATGGTTACATGGCTCCTGAG
ATCCTAATGGAAAAGGTAAGTTATTCCTATCCTGTGGACTGGTTTGCCATGGGATGCAGC
ATTTATGAAATGGTTGCTGGACGAACACCATTCAAAGATTACAAGGAAAAGGTCAGTAAA
GAGGATCTGAAGCAAAGAACTCTGCAAGACGAGGTCAAATTCCAGCATGATAACTTCACA
GAGGAAGCAAAAGATATTTGCAGGCTCTTCTTGGCTAAGAAACCAGAGCAACGCTTAGGA
AGCAGAGAAAAGTCTGATGATCCCAGGAAACATCATTTCTTTAAAACGATCAACTTTCCT
CGCCTGGAAGCTGGCCTAATTGAACCCCCATTTGTGCCAGACCCTTCAGTGGTTTATGCC
AAAGACATCGCTGAAATTGATGATTTCTCTGAGGTTCGGGGGGTGGAATTTGATGACAAA
GATAAGCAGTTCTTCAAAAACTTTGCGACAGGTGCTGTTCCTATAGCATGGCAGGAAGAA
ATTATAGAAACGGGACTGTTTGAGGAACTGAATGACCCCAACAGACCTACGGGTTGTGAG
GAGGGTAATTCATCCAAGTCTGGCGTGTGTTTGTTATTGTAA
Protein Properties
Number of Residues 553
Molecular Weight 62211.0
Theoretical pI 6.52
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>G protein-coupled receptor kinase 7
MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLC
EQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPG
NPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKL
FEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEK
EILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQI
ACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPE
ILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFT
EEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYA
KDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCE
EGNSSKSGVCLLL
GenBank ID Protein 17026318
UniProtKB/Swiss-Prot ID Q8WTQ7
UniProtKB/Swiss-Prot Entry Name GRK7_HUMAN
PDB IDs Not Available
GenBank Gene ID AF282269
GeneCard ID GRK7
GenAtlas ID GRK7
HGNC ID HGNC:17031
References
General References
  1. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
  2. Chen CK, Zhang K, Church-Kopish J, Huang W, Zhang H, Chen YJ, Frederick JM, Baehr W: Characterization of human GRK7 as a potential cone opsin kinase. Mol Vis. 2001 Dec 21;7:305-13. [PubMed:11754336 ]
  3. Weiss ER, Ducceschi MH, Horner TJ, Li A, Craft CM, Osawa S: Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction. J Neurosci. 2001 Dec 1;21(23):9175-84. [PubMed:11717351 ]