Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP10113
Secondary Accession Numbers
  • 16066
Name Ubiquitin carboxyl-terminal hydrolase 51
Synonyms
  1. Deubiquitinating enzyme 51
  2. Ubiquitin thiolesterase 51
  3. Ubiquitin-specific-processing protease 51
Gene Name USP51
Protein Type Enzyme
Biological Properties
General Function Involved in ubiquitin thiolesterase activity
Specific Function Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
transition metal ion binding
zinc ion binding
ubiquitin thiolesterase activity
thiolester hydrolase activity
Process
metabolic process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs USP51
Gene Sequence
>2136 bp
ATGGCCCAGGTTCGAGAAACTTCTTTGCCCTCCGGCTCTGGGGTCCGCTGGATCTCCGGA
GGTGGGGGAGGAGCCTCTCCTGAGGAGGCGGTTGAGAAGGCGGGGAAAATGGAGGAGGCG
GCGGCGGGGGCTACGAAGGCGTCTTCGAGACGTGAAGCCGAGGAGATGAAGCTGGAGCCA
TTACAAGAGCGTGAGCCCGCGCCGGAGGAGAACTTGACGTGGAGCAGCAGCGGCGGCGAC
GAGAAGGTGCTCCCTTCAATCCCCCTTCGCTGTCACAGCAGCTCCTCGCCCGTTTGCCCG
CGCCGCAAGCCCCGCCCTCGGCCCCAGCCCCGGGCCCGCTCCCGCAGCCAGCCTGGGCTC
TCGGCCCCACCCCCGCCTCCAGCCCGGCCCCCGCCCCCGCCGCCACCCCCGCCCCCACCC
GCACCGCGGCCCAGGGCCTGGCGTGGATCCCGGCGCAGATCCCGGCCTGGGTCCAGGCCT
CAGACACGGAGAAGCTGCTCTGGTGACCTAGACGGGTCGGGGGATCCTGGCGGCTTAGGG
GACTGGTTGCTGGAGGTCGAGTTTGGTCAGGGTCCCACAGGCTGCTCTCATGTGGAGAGC
TTTAAAGTAGGTAAGAACTGGCAGAAGAACCTGAGGTTGATCTACCAGCGTTTCGTTTGG
AGTGGGACCCCAGAGACTAGGAAACGTAAAGCAAAGTCATGCATCTGTCACGTATGTAGT
ACCCATATGAACAGACTCCACTCTTGTCTCTCCTGTGTCTTTTTTGGCTGCTTCACTGAG
AAACATATTCACAAACATGCAGAAACAAAGCAGCACCATTTAGCTGTAGACCTTTATCAT
GGGGTCATATATTGCTTCATGTGTAAGGATTATGTATATGACAAAGACATAGAACAGATT
GCCAAAGAAACAAAAGAAAAAATTTTGAGATTATTAACTTCCACCTCAACAGATGTTTCT
CATCAACAGTTTATGACATCAGGGTTTGAAGACAAGCAATCAACCTGTGAGACAAAGGAA
CAGGAGCCAAAATTGGTGAAACCCAAGAAAAAGAGAAGAAAAAAGTCAGTCTATACTGTA
GGCCTGAGAGGGCTAATCAATCTTGGGAACACTTGTTTTATGAATTGTATTGTCCAGGCA
CTTACCCATATTCCTCTACTGAAAGATTTCTTCCTCTCTGACAAGCACAAATGTATAATG
ACAAGCCCCAGCTTGTGTCTGGTCTGTGAAATGTCTTCGCTTTTTCATGCTATGTACTCT
GGGAGCCGAACTCCTCACATTCCCTATAAGTTACTGCATCTGATATGGATCCATGCAGAA
CATTTAGCAGGGTACAGGCAGCAGGATGCCCATGAGTTCCTTATTGCAATATTAGACGTG
CTACATAGACACAGCAAAGATGATAGTGGTGGGCAGGAGGCCAATAACCCCAACTGCTGT
AACTGCATCATAGACCAAATCTTTACAGGTGGCCTGCAATCAGATGTCACATGTCAAGCC
TGCCATAGTGTTTCTACCACCATAGACCCATGCTGGGACATCAGTTTGGACTTGCCTGGC
TCTTGTGCCACATTCGATTCCCAGAACCCAGAGAGGGCTGACAGCACAGTGAGCAGGGAT
GACCACATACCAGGAATCCCCTCACTTACAGACTGTCTACAGTGGTTTACAAGGCCAGAG
CACCTAGGAAGCAGTGCCAAAATCAAATGCAATAGTTGCCAAAGCTACCAGGAGTCTACT
AAACAGCTCACAATGAAAAAATTACCCATTGTGGCTTGTTTTCATCTCAAGCGGTTTGAG
CATGTAGGCAAACAGAGGCGAAAGATTAATACCTTTATCTCCTTTCCCTTGGAGCTGGAC
ATGACTCCGTTTTTGGCCTCTACTAAAGAGAGCAGAATGAAAGAAGGCCAGCCACCAACA
GATTGTGTGCCCAATGAGAATAAGTATTCCTTGTTTGCAGTGATTAATCACCATGGAACT
TTGGAAAGTGGCCACTATACCAGCTTCATCCGGCAACAAAAGGACCAGTGGTTCAGCTGT
GATGATGCCATCATCACCAAGGCTACCATTGAGGACTTACTCTACAGTGAAGGGTATTTA
CTGTTCTATCACAAACAGGGTCTAGAGAAAGACTAG
Protein Properties
Number of Residues 711
Molecular Weight 79755.2
Theoretical pI 8.44
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Ubiquitin carboxyl-terminal hydrolase 51
MAQVRETSLPSGSGVRWISGGGGGASPEEAVEKAGKMEEAAAGATKASSRREAEEMKLEP
LQEREPAPEENLTWSSSGGDEKVLPSIPLRCHSSSSPVCPRRKPRPRPQPRARSRSQPGL
SAPPPPPARPPPPPPPPPPPAPRPRAWRGSRRRSRPGSRPQTRRSCSGDLDGSGDPGGLG
DWLLEVEFGQGPTGCSHVESFKVGKNWQKNLRLIYQRFVWSGTPETRKRKAKSCICHVCS
THMNRLHSCLSCVFFGCFTEKHIHKHAETKQHHLAVDLYHGVIYCFMCKDYVYDKDIEQI
AKETKEKILRLLTSTSTDVSHQQFMTSGFEDKQSTCETKEQEPKLVKPKKKRRKKSVYTV
GLRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLCLVCEMSSLFHAMYS
GSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRHSKDDSGGQEANNPNCC
NCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCATFDSQNPERADSTVSRD
DHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFE
HVGKQRRKINTFISFPLELDMTPFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGT
LESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLYSEGYLLFYHKQGLEKD
GenBank ID Protein 40788183
UniProtKB/Swiss-Prot ID Q70EK9
UniProtKB/Swiss-Prot Entry Name UBP51_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ583823
GeneCard ID USP51
GenAtlas ID USP51
HGNC ID HGNC:23086
References
General References
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