Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP10687
Secondary Accession Numbers
  • 16946
Name GDP-fucose protein O-fucosyltransferase 2
Synonyms
  1. O-FucT-2
  2. Peptide-O-fucosyltransferase 2
Gene Name POFUT2
Protein Type Enzyme
Biological Properties
General Function Involved in peptide-O-fucosyltransferase activity
Specific Function Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in thrombospondin type 1 repeats
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Endoplasmic reticulum
Gene Properties
Chromosome Location Chromosome:2
Locus 21q22.3
SNPs POFUT2
Gene Sequence
>1290 bp
ATGGCGACACTCAGCTTCGTCTTCCTGCTGCTGGGGGCAGTGTCCTGGCCTCCGGCTTCT
GCCTCCGGCCAGGAGTTCTGGCCCGGACAATCGGCGGCCGATATTCTGTCGGGGGCGGCT
TCCCGCAGACGGTATCTTCTGTATGACGTCAACCCCCCGGAAGGCTTCAACCTGCGCAGG
GATGTCTATATCCGAATCGCCTCTCTCCTGAAGACTCTGCTGAAGACGGAGGAGTGGGTG
CTTGTCCTGCCTCCATGGGGCCGCCTCTATCACTGGCAGAGTCCTGACATCCACCAGGTC
CGGATTCCCTGGTCTGAGTTTTTTGATCTTCCAAGTCTCAATAAAAACATCCCCGTCATC
GAGTATGAGCAGTTCATCGCAGAATCTGGTGGGCCCTTTATTGACCAGGTTTACGTCCTG
CAAAGTTACGCAGAGGGGTGGAAAGAAGGGACCTGGGAAGAGAAGGTGGACGAGCGGCCG
TGTATTGATCAGCTCCTGTACTCCCAGGACAAGCACGAGTACTACAGAGGATGGTTTTGG
GGTTATGAGGAGACCAGGGGTCTAAACGTCTCCTGTCTGTCCGTCCAGGGCTCAGCCTCC
ATCGTGGCGCCCCTGCTGCTGAGAAACACATCAGCCCGGTCCGTGATGTTAGACAGAGCC
GAGAACCTACTTCACGACCACTATGGAGGGAAAGAATACTGGGATACCCGTCGCAGCATG
GTGTTTGCCAGGCACCTGCGGGAGGTGGGAGACGAGTTCAGGAGCAGACATCTCAACTCC
ACGGACGACGCAGACAGGATCCCCTTCCAGGAGGACTGGATGAAGATGAAGGTCAAGCTG
GGCTCCGCGCTAGGGGGCCCCTACCTGGGAGTCCACCTGAGAAGAAAAGATTTCATCTGG
GGTCACAGACAGGATGTACCCAGTCTGGAAGGGGCCGTGAGGAAGATCCGCAGCCTCATG
AAGACCCACCGGCTGGACAAGGTGTTTGTGGCCACAGATGCCGTCAGAAAGGAATATGAA
GAGCTAAAAAAGCTGTTACCCGAGATGGTGAGGTTTGAACCCACGTGGGAGGAGCTGGAG
CTCTACAAGGACGGAGGCGTTGCGATTATTGACCAGTGGATCTGCGCACACGCCAGGTTT
TTTATTGGCACCTCAGTCTCAACATTTTCTTTTCGGATTCATGAGGAAAGAGAAATCCTG
GGGTTGGACCCCAAGACGACGTACAACAGGTTCTGCGGAGACCAAGAGAAGGCGTGTGAG
CAACCCACCCACTGGAAGATCACCTACTGA
Protein Properties
Number of Residues 429
Molecular Weight 49975.4
Theoretical pI 6.58
Pfam Domain Function
Signals
  • 1-21
Transmembrane Regions
  • None
Protein Sequence
>GDP-fucose protein O-fucosyltransferase 2
MATLSFVFLLLGAVSWPPASASGQEFWPGQSAADILSGAASRRRYLLYDVNPPEGFNLRR
DVYIRIASLLKTLLKTEEWVLVLPPWGRLYHWQSPDIHQVRIPWSEFFDLPSLNKNIPVI
EYEQFIAESGGPFIDQVYVLQSYAEGWKEGTWEEKVDERPCIDQLLYSQDKHEYYRGWFW
GYEETRGLNVSCLSVQGSASIVAPLLLRNTSARSVMLDRAENLLHDHYGGKEYWDTRRSM
VFARHLREVGDEFRSRHLNSTDDADRIPFQEDWMKMKVKLGSALGGPYLGVHLRRKDFIW
GHRQDVPSLEGAVRKIRSLMKTHRLDKVFVATDAVRKEYEELKKLLPEMVRFEPTWEELE
LYKDGGVAIIDQWICAHARFFIGTSVSTFSFRIHEEREILGLDPKTTYNRFCGDQEKACE
QPTHWKITY
GenBank ID Protein 34147487
UniProtKB/Swiss-Prot ID Q9Y2G5
UniProtKB/Swiss-Prot Entry Name OFUT2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_133635.4
GeneCard ID POFUT2
GenAtlas ID POFUT2
HGNC ID HGNC:14683
References
General References
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  2. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  3. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML: The DNA sequence of human chromosome 21. Nature. 2000 May 18;405(6784):311-9. [PubMed:10830953 ]
  4. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Feb 26;6(1):63-70. [PubMed:10231032 ]
  5. Menzel O, Vellai T, Takacs-Vellai K, Reymond A, Mueller F, Antonarakis SE, Guipponi M: The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development. Genomics. 2004 Aug;84(2):320-30. [PubMed:15233996 ]
  6. Martinez-Duncker I, Mollicone R, Candelier JJ, Breton C, Oriol R: A new superfamily of protein-O-fucosyltransferases, alpha2-fucosyltransferases, and alpha6-fucosyltransferases: phylogeny and identification of conserved peptide motifs. Glycobiology. 2003 Dec;13(12):1C-5C. Epub 2003 Sep 9. [PubMed:12966037 ]
  7. Luo Y, Nita-Lazar A, Haltiwanger RS: Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats. J Biol Chem. 2006 Apr 7;281(14):9385-92. Epub 2006 Feb 7. [PubMed:16464858 ]