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Identification
HMDB Protein ID HMDBP10696
Secondary Accession Numbers
  • 16957
Name Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Synonyms
  1. hLHPP
Gene Name LHPP
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).
Pathways
  • Oxidative phosphorylation
Reactions
Pyrophosphate + Water → Phosphate details
GO Classification
Biological Process
protein dephosphorylation
Cellular Component
cytosol
nucleus
Function
catalytic activity
hydrolase activity
Molecular Function
magnesium ion binding
phosphohistidine phosphatase activity
inorganic diphosphatase activity
Process
metabolic process
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location 10
Locus 10q26.13
SNPs LHPP
Gene Sequence
>813 bp
ATGGCACCGTGGGGCAAGCGGCTGGCTGGCGTGCGCGGGGTGCTGCTTGACATCTCGGGC
GTGCTGTACGACAGCGGCGCGGGCGGCGGCACGGCCATCGCCGGCTCGGTGGAGGCGGTG
GCCAGACTGAAGCGTTCCCGGCTGAAGGTGAGGTTCTGCACCAACGAGTCGCAGAAGTCC
CGGGCAGAGCTGGTGGGGCAGCTTCAGAGGCTGGGATTTGACATCTCTGAGCAGGAGGTG
ACCGCCCCGGCACCAGCTGCCTGCCAGATCCTGAAGGAGCGAGGCCTGCGACCATACCTG
CTCATCCATGACGGAGTCCGCTCAGAATTTGATCAGATCGACACATCCAACCCAAACTGT
GTGGTAATTGCAGACGCAGGAGAAAGCTTTTCTTATCAAAACATGAATAACGCCTTCCAG
GTGCTCATGGAGCTGGAAAAACCTGTGCTCATATCACTGGGAAAAGGGCGTTACTACAAG
GAGACCTCTGGCCTGATGCTGGACGTTGGTCCCTACATGAAGGCGCTTGAGTATGCCTGT
GGCATCAAAGCCGAGGTGGTGGGGAAGCCTTCTCCTGAGTTTTTCAAGTCTGCCCTGCAA
GCGATAGGAGTGGAAGCCCACCAGGCCGTCATGATTGGGGACGATATCGTGGGCGACGTC
GGCGGTGCCCAGCGGTGTGGAATGAGAGCGCTGCAGGTGCGCACCGGGAAGTTCAGGCCC
AGTGACGAGCACCATCCGGAAGTGAAGGCTGATGGGTACGTGGACAACCTCGCAGAGGCA
GTGGACCTGCTGCTGCAGCACGCCGACAAGTGA
Protein Properties
Number of Residues 270
Molecular Weight 22695.865
Theoretical pI 7.208
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
MAPWGKRLAGVRGVLLDISGVLYDSGAGGGTAIAGSVEAVARLKRSRLKVRFCTNESQKS
RAELVGQLQRLGFDISEQEVTAPAPAACQILKEQGLRPYLLIHDGVRSEFDQIDTSNPNC
VVIADAGESFSYQNMNNAFQVLMELEKPVLISLGKGRYYKETSGLMLDVGPYMKALEYAC
GIKAEVVGKPSPEFFKSALQAIGVEAHQAVMIGDDIVGDVGGAQRCGMRALQVRTGKFRP
SDEHHPEVKADGYVDNLAEAVDLLLQHADK
GenBank ID Protein 10716807
UniProtKB/Swiss-Prot ID Q9H008
UniProtKB/Swiss-Prot Entry Name LHPP_HUMAN
PDB IDs
GenBank Gene ID AB049629
GeneCard ID LHPP
GenAtlas ID LHPP
HGNC ID HGNC:30042
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [PubMed:15164054 ]
  3. Yokoi F, Hiraishi H, Izuhara K: Molecular cloning of a cDNA for the human phospholysine phosphohistidine inorganic pyrophosphate phosphatase. J Biochem. 2003 May;133(5):607-14. [PubMed:12801912 ]