Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP10715
Secondary Accession Numbers
  • 16977
Name Selenium-binding protein 1
Synonyms
  1. 56 kDa selenium-binding protein
  2. SBP56
  3. SP56
Gene Name SELENBP1
Protein Type Unknown
Biological Properties
General Function Involved in selenium binding
Specific Function Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
selenium binding
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. Peripheral membrane protein
  4. Membrane
  5. cytosol
Gene Properties
Chromosome Location Chromosome:1
Locus 1q21.3
SNPs SELENBP1
Gene Sequence
>1419 bp
ATGGCTACGAAATGTGGGAATTGTGGACCCGGCTACTCCACCCCTCTGGAGGCCATGAAA
GGACCCAGGGAAGAGATCGTCTACCTGCCCTGCATTTACCGAAACACAGGCACTGAGGCC
CCAGATTATCTGGCCACTGTGGATGTTGACCCCAAGTCTCCCCAGTATTGCCAGGTCATC
CACCGGCTGCCCATGCCCAACCTGAAGGACGAGCTGCATCACTCAGGATGGAACACCTGC
AGCAGCTGCTTCGGTGATAGCACCAAGTCGCGCACCAAGCTGGTGCTGCCCAGTCTCATC
TCCTCTCGCATCTATGTGGTGGACGTGGGCTCTGAGCCCCGGGCCCCAAAGCTGCACAAG
GTCATTGAGCCCAAGGACATCCATGCCAAGTGCGAACTGGCCTTTCTCCACACCAGCCAC
TGCCTGGCCAGCGGGGAAGTGATGATCAGCTCCCTGGGAGACGTCAAGGGCAATGGCAAA
GGGGGTTTTGTGCTGCTGGATGGGGAGACGTTCGAGGTGAAGGGGACATGGGAGAGACCT
GGGGGTGCTGCACCGTTGGGCTATGACTTCTGGTACCAGCCTCGACACAATGTCATGATC
AGCACTGAGTGGGCAGCTCCCAATGTCTTACGAGATGGCTTCAACCCCGCTGATGTGGAG
GCTGGACTGTACGGGAGCCACTTATATGTATGGGACTGGCAGCGCCATGAGATTGTGCAG
ACCCTGTCTCTAAAAGATGGGCTTATTCCCTTGGAGATCCGCTTCCTGCACAACCCAGAC
GCTGCCCAAGGCTTTGTGGGCTGCGCACTCAGCTCCACCATCCAGCGCTTCTACAAGAAC
GAGGGAGGTACATGGTCAGTGGAGAAGGTGATCCAGGTGCCCCCCAAGAAAGTGAAGGGC
TGGCTGCTGCCCGAAATGCCAGGCCTGATCACCGACATCCTGCTCTCCCTGGACGACCGC
TTCCTCTACTTCAGCAACTGGCTGCATGGGGACCTGAGGCAGTATGACATCTCTGACCCA
CAGAGACCCCGCCTCACAGGACAGCTCTTCCTCGGAGGCAGCATTGTTAAGGGAGGCCCT
GTTCAAGTGCTGGAGGACGAGGAACTAAAGTCCCAGCCAGAGCCCCTAGTGGTCAAGGGA
AAACGGGTGGCTGGAGGCCCTCAGATGATCCAGCTCAGCCTGGATGGGAAGCGCCTCTAC
ATCACCACGTCGCTGTACAGTGCCTGGGACAAGCAGTTTTACCCTGATCTCATCAGGGAA
GGCTCTGTGATGCTGCAGGTTGATGTAGACACAGTAAAAGGAGGGCTGAAGTTGAACCCC
AACTTCCTGGTGGACTTCGGGAAGGAGCCCCTTGGCCCAGCCCTTGCCCATGAGCTCCGC
TACCCTGGGGGCGATTGTAGCTCTGACATCTGGATTTGA
Protein Properties
Number of Residues 472
Molecular Weight 52390.6
Theoretical pI 6.32
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Selenium-binding protein 1
MATKCGNCGPGYSTPLEAMKGPREEIVYLPCIYRNTGTEAPDYLATVDVDPKSPQYCQVI
HRLPMPNLKDELHHSGWNTCSSCFGDSTKSRTKLVLPSLISSRIYVVDVGSEPRAPKLHK
VIEPKDIHAKCELAFLHTSHCLASGEVMISSLGDVKGNGKGGFVLLDGETFEVKGTWERP
GGAAPLGYDFWYQPRHNVMISTEWAAPNVLRDGFNPADVEAGLYGSHLYVWDWQRHEIVQ
TLSLKDGLIPLEIRFLHNPDAAQGFVGCALSSTIQRFYKNEGGTWSVEKVIQVPPKKVKG
WLLPEMPGLITDILLSLDDRFLYFSNWLHGDLRQYDISDPQRPRLTGQLFLGGSIVKGGP
VQVLEDEELKSQPEPLVVKGKRVAGGPQMIQLSLDGKRLYITTSLYSAWDKQFYPDLIRE
GSVMLQVDVDTVKGGLKLNPNFLVDFGKEPLGPALAHELRYPGGDCSSDIWI
GenBank ID Protein 189055026
UniProtKB/Swiss-Prot ID Q13228
UniProtKB/Swiss-Prot Entry Name SBP1_HUMAN
PDB IDs Not Available
GenBank Gene ID AK315643
GeneCard ID SELENBP1
GenAtlas ID SELENBP1
HGNC ID HGNC:10719
References
General References
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  3. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. [PubMed:16710414 ]
  4. Jeong JY, Wang Y, Sytkowski AJ: Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner. Biochem Biophys Res Commun. 2009 Feb 6;379(2):583-8. doi: 10.1016/j.bbrc.2008.12.110. Epub 2008 Dec 30. [PubMed:19118533 ]
  5. Chang PW, Tsui SK, Liew C, Lee CC, Waye MM, Fung KP: Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein. J Cell Biochem. 1997 Feb;64(2):217-24. [PubMed:9027582 ]
  6. Yang M, Sytkowski AJ: Differential expression and androgen regulation of the human selenium-binding protein gene hSP56 in prostate cancer cells. Cancer Res. 1998 Jul 15;58(14):3150-3. [PubMed:9679983 ]
  7. Chen G, Wang H, Miller CT, Thomas DG, Gharib TG, Misek DE, Giordano TJ, Orringer MB, Hanash SM, Beer DG: Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas. J Pathol. 2004 Mar;202(3):321-9. [PubMed:14991897 ]
  8. Glatt SJ, Everall IP, Kremen WS, Corbeil J, Sasik R, Khanlou N, Han M, Liew CC, Tsuang MT: Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15533-8. Epub 2005 Oct 13. [PubMed:16223876 ]
  9. Huang KC, Park DC, Ng SK, Lee JY, Ni X, Ng WC, Bandera CA, Welch WR, Berkowitz RS, Mok SC, Ng SW: Selenium binding protein 1 in ovarian cancer. Int J Cancer. 2006 May 15;118(10):2433-40. [PubMed:16380993 ]
  10. Kim H, Kang HJ, You KT, Kim SH, Lee KY, Kim TI, Kim C, Song SY, Kim HJ, Lee C, Kim H: Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival. Proteomics. 2006 Jun;6(11):3466-76. [PubMed:16645984 ]