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| Identification |
|---|
| HMDB Protein ID
| HMDBP10727 |
| Secondary Accession Numbers
| |
| Name
| Fibroblast growth factor 4 |
| Synonyms
|
- FGF-4
- HBGF-4
- HST
- HST-1
- HSTF-1
- Heparin secretory-transforming protein 1
- Heparin-binding growth factor 4
- Transforming protein KS3
|
| Gene Name
| FGF4 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in growth factor activity |
| Specific Function
| Can transform NIH 3T3 cells from a human stomach tumor (hst) and from karposi's sarcoma (KS3). It has a mitogenic activity |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Function |
| binding |
| protein binding |
| receptor binding |
| growth factor activity |
|
| Cellular Location
|
- Secreted (Potential)
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q13.3 |
| SNPs
| FGF4 |
| Gene Sequence
|
>621 bp
ATGTCGGGGCCCGGGACGGCCGCGGTAGCGCTGCTCCCGGCGGTCCTGCTGGCCTTGCTG
GCGCCCTGGGCGGGCCGAGGGGGCGCCGCCGCACCCACTGCACCCAACGGCACGCTGGAG
GCCGAGCTGGAGCGCCGCTGGGAGAGCCTGGTGGCGCTCTCGTTGGCGCGCCTGCCGGTG
GCAGCGCAGCCCAAGGAGGCGGCCGTCCAGAGCGGCGCCGGCGACTACCTGCTGGGCATC
AAGCGGCTGCGGCGGCTCTACTGCAACGTGGGCATCGGCTTCCACCTCCAGGCGCTCCCC
GACGGCCGCATCGGCGGCGCGCACGCGGACACCCGCGACAGCCTGCTGGAGCTCTCGCCC
GTGGAGCGGGGCGTGGTGAGCATCTTCGGCGTGGCCAGCCGGTTCTTCGTGGCCATGAGC
AGCAAGGGCAAGCTCTATGGCTCGCCCTTCTTCACCGATGAGTGCACGTTCAAGGAGATT
CTCCTTCCCAACAACTACAACGCCTACGAGTCCTACAAGTACCCCGGCATGTTCATCGCC
CTGAGCAAGAATGGGAAGACCAAGAAGGGGAACCGAGTGTCGCCCACCATGAAGGTCACC
CACTTCCTCCCCAGGCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 206 |
| Molecular Weight
| 22047.4 |
| Theoretical pI
| 10.19 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Fibroblast growth factor 4
MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPV
AAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSP
VERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIA
LSKNGKTKKGNRVSPTMKVTHFLPRL
|
| External Links |
|---|
| GenBank ID Protein
| 386788 |
| UniProtKB/Swiss-Prot ID
| P08620 |
| UniProtKB/Swiss-Prot Entry Name
| FGF4_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| J02986 |
| GeneCard ID
| FGF4 |
| GenAtlas ID
| FGF4 |
| HGNC ID
| HGNC:3682 |
| References |
|---|
| General References
| - Yoshida T, Miyagawa K, Odagiri H, Sakamoto H, Little PF, Terada M, Sugimura T: Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. Proc Natl Acad Sci U S A. 1987 Oct;84(20):7305-9. [PubMed:2959959 ]
- Taira M, Yoshida T, Miyagawa K, Sakamoto H, Terada M, Sugimura T: cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. Proc Natl Acad Sci U S A. 1987 May;84(9):2980-4. [PubMed:2953031 ]
- Delli Bovi P, Curatola AM, Kern FG, Greco A, Ittmann M, Basilico C: An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family. Cell. 1987 Aug 28;50(5):729-37. [PubMed:2957062 ]
- Bellosta P, Iwahori A, Plotnikov AN, Eliseenkova AV, Basilico C, Mohammadi M: Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis. Mol Cell Biol. 2001 Sep;21(17):5946-57. [PubMed:11486033 ]
|
