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Identification
HMDB Protein ID HMDBP10798
Secondary Accession Numbers
  • 17072
Name Adenosine 3'-phospho 5'-phosphosulfate transporter 2
Synonyms
  1. 3'-phosphoadenosine 5'-phosphosulfate transporter
  2. PAPS transporter 2
  3. Solute carrier family 35 member B3
Gene Name SLC35B3
Protein Type Unknown
Biological Properties
General Function Involved in transmembrane transport
Specific Function Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon
Pathways Not Available
Reactions Not Available
GO Classification
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Golgi apparatus membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:6
Locus 6p24.3
SNPs SLC35B3
Gene Sequence
>1206 bp
ATGGACTTGACACAGCAAGCAAAAGACATACAGAACATAACAGTCCAGGAAACCAACAAA
AATAACTCTGAAAGCATTGAATGCAGCAAAATAACAATGGATCTCAAGTTCAACAATTCC
AGGAAATATATTTCTATCACTGTGCCATCCAAAACCCAAACAATGTCACCACACATCAAG
TCAGTTGACGACGTTGTGGTACTTGGCATGAATCTCAGCAAGTTTAACAAACTTACTCAG
TTTTTCATATGTGTTGCTGGAGTTTTTGTATTTTACCTAATTTATGGGTATTTACAGGAA
TTAATATTTTCAGTGGAGGGTTTTAAGTCCTGTGGCTGGTACCTTACCTTAGTGCAGTTT
GCCTTTTACTCCATATTTGGCCTAATAGAACTTCAGCTTATTCAGGACAAAAGGAGGAGA
ATACCAGGAAAAACCTACATGATAATAGCTTTTCTAACTGTGGGTACTATGGGGTTATCA
AACACTTCCTTGGGCTACCTGAATTACCCTACCCAAGTCATCTTCAAGTGCTGCAAATTG
ATTCCTGTTATGCTAGGAGGAGTTTTTATTCAAGGAAAGCGTTATAATGTTGCAGATGTG
TCTGCTGCCATATGTATGAGCCTTGGCCTGATATGGTTTACCCTCGCTGACAGCACAACT
GCACCAAATTTCAACCTGACGGGTGTGGTGCTTATTTCCCTGGCACTATGTGCAGATGCC
GTCATTGGAAATGTTCAAGAGAAAGCTATGAAACTTCATAATGCTTCTAATTCTGAAATG
GTATTGTATTCGTATTCAATTGGTTTTGTATACATTTTACTGGGATTGACATGCACTAGT
GGATTAGGCCCTGCAGTAACATTTTGTGCAAAGAATCCAGTTCGGACCTATGGTTATGCG
TTCCTTTTTTCCCTCACTGGATATTTTGGAATCTCCTTTGTTCTGGCTTTGATTAAAATT
TTTGGTGCACTTATTGCTGTAACAGTGACAACAGGAAGAAAAGCAATGACCATTGTACTT
TCGTTTATATTCTTTGCTAAACCATTCACGTTTCAGTATGTATGGTCTGGTTTGTTAGTT
GTCCTTGGTATATTTCTTAATGTTTACAGCAAAAATATGGATAAAATAAGACTACCATCA
CTGTATGATTTGATAAACAAATCAGTGGAAGCAAGAAAGTCAAGGACGCTGGCACAGACT
GTATAG
Protein Properties
Number of Residues 401
Molecular Weight 44592.3
Theoretical pI 9.58
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 78-98
  • 114-134
  • 147-167
  • 170-190
  • 196-216
  • 223-243
  • 267-287
  • 298-317
  • 324-346
  • 349-369
Protein Sequence
>Adenosine 3'-phospho 5'-phosphosulfate transporter 2
MDLTQQAKDIQNITVQETNKNNSESIECSKITMDLKFNNSRKYISITVPSKTQTMSPHIK
SVDDVVVLGMNLSKFNKLTQFFICVAGVFVFYLIYGYLQELIFSVEGFKSCGWYLTLVQF
AFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKL
IPVMLGGVFIQGKRYNVADVSAAICMSLGLIWFTLADSTTAPNFNLTGVVLISLALCADA
VIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLTCTSGLGPAVTFCAKNPVRTYGYA
FLFSLTGYFGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLV
VLGIFLNVYSKNMDKIRLPSLYDLINKSVEARKSRTLAQTV
GenBank ID Protein 90991129
UniProtKB/Swiss-Prot ID Q9H1N7
UniProtKB/Swiss-Prot Entry Name S35B3_HUMAN
PDB IDs Not Available
GenBank Gene ID AB231931
GeneCard ID SLC35B3
GenAtlas ID SLC35B3
HGNC ID HGNC:21601
References
General References
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  4. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res. 2000 May;10(5):703-13. [PubMed:10810093 ]
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