Showing Protein Potassium voltage-gated channel subfamily D member 2 (HMDBP10843)

• 17133

1. Voltage-gated potassium channel subunit Kv4.2

• 3-Methylthiofentanyl Action Pathway
• Alfentanil Action Pathway
• Alvimopan Action Pathway
• Anileridine Action Pathway
• Benzocaine Action Pathway
• Bupivacaine Action Pathway
• Buprenorphine Action Pathway
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• Chloroprocaine Action Pathway
• Citalopram Action Pathway
• Cocaine Action Pathway
• Codeine Action Pathway
• Desipramine Action Pathway
• Dezocine Action Pathway
• Dibucaine Action Pathway
• Dihydromorphine Action Pathway
• Dimethylthiambutene Action Pathway
• Diphenoxylate Action Pathway
• Escitalopram Action Pathway
• Ethylmorphine Action Pathway
• Fentanyl Action Pathway
• Fluoxetine Action Pathway
• Heroin Action Pathway
• Hydrocodone Action Pathway
• Hydromorphone Action Pathway
• Imipramine Action Pathway
• Ketobemidone Action Pathway
• Levallorphan Action Pathway
• Levobupivacaine Action Pathway
• Levomethadyl Acetate Action Action Pathway
• Levorphanol Action Pathway
• Lidocaine (Local Anaesthetic) Action Pathway
• Mepivacaine Action Pathway
• Methadone Action Pathway
• Methadyl Acetate Action Pathway
• Morphine Action Pathway
• Nalbuphine Action Pathway
• Naloxone Action Pathway
• Naltrexone Action Pathway
• Nicotine Action Pathway
• Oxybuprocaine Action Pathway
• Oxycodone Action Pathway
• Oxymorphone Action Pathway
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• Proparacaine Action Pathway
• Propoxyphene Action Pathway
• Remifentanil Action Pathway
• Ropivacaine Action Pathway
• Sufentanil Action Pathway
• Tramadol Action Action Pathway

1. Cell membrane
2. Multi-pass membrane protein
3. Cell projection
4. dendrite

>1893 bp
ATGGCGGCGGGGGTGGCAGCGTGGCTGCCTTTTGCAAGGGCAGCGGCTATCGGGTGGATG
CCTGTGGCCTCGGGGCCTATGCCGGCTCCCCCGAGGCAGGAGAGGAAAAGGACCCAAGAT
GCTCTCATTGTGCTGAATGTGAGTGGCACCCGCTTCCAGACGTGGCAGGACACCCTGGAA
CGTTACCCAGACACTCTACTGGGCAGTTCTGAGAGGGACTTTTTCTACCACCCAGAAACT
CAGCAGTATTTCTTTGACCGTGACCCAGACATCTTCCGCCACATCCTGAATTTCTACCGC
ACTGGGAAGCTCCACTATCCTCGCCACGAGTGCATCTCTGCTTACGATGAAGAACTGGCC
TTCTTTGGCCTCATCCCGGAAATCATCGGCGACTGCTGTTATGAGGAGTACAAGGATCGC
AGGCGAGAGAACGCCGAGCGCCTGCAGGACGACGCGGATACCGACACCGCTGGGGAGAGC
GCCTTGCCCACCATGACTGCAAGGCAGAGGGTCTGGAGGGCCTTCGAGAACCCCCACACC
AGCACGATGGCCCTGGTGTTCTACTATGTCACGGGGTTTTTCATTGCCGTCTCTGTCATC
GCGAATGTGGTGGAAACAGTGCCGTGCGGATCAAGCCCAGGTCACATTAAAGAACTGCCC
TGTGGAGAGCGGTATGCTGTGGCCTTCTTCTGCTTGGACACGGCCTGCGTCATGATCTTC
ACAGTTGAGTATTTGCTTCGCCTGGCTGCAGCGCCTAGTCGTTACCGTTTTGTGCGTAGT
GTCATGAGTATCATCGACGTGGTGGCCATCCTGCCTTATTACATTGGGCTGGTGATGACA
GACAATGAGGACGTCAGCGGAGCCTTTGTCACACTCCGAGTCTTCCGGGTCTTCAGGATC
TTTAAGTTTTCCCGCCACTCTCAAGGCCTGCGCATCCTGGGGTACACACTGAAGAGTTGT
GCCTCAGAATTGGGCTTCTTGCTTTTCTCGCTCACCATGGCTATCATCATTTTCGCTACG
GTTATGTTCTACGCAGAGAAGGGCTCTTCAGCAAGCAAGTTCACCAGCATCCCTGCAGCC
TTCTGGTACACCATCGTCACCATGACAACACTGGGGTATGGCGACATGGTACCAAAAACC
ATAGCAGGGAAGATTTTCGGGTCTATCTGCTCACTGAGCGGAGTCTTGGTCATCGCGCTA
CCCGTGCCTGTGATCGTGTCTAACTTCAGTCGGATCTACCACCAAAACCAACGAGCGGAC
AAACGAAGGGCACAGAAGAAAGCGAGGCTGGCCAGGATCCGGGCAGCCAAAAGTGGAAGT
GCAAATGCCTACATGCAGAGCAAGCGGAGTGGGTTACTGAGCAACCAACTGCAGTCCTCG
GAGGATGAACCGGCCTTCGTTAGCAAATCTGGATCCAGCTTCGAGACGCAACACCACCAC
CTGCTTCACTGCCTGGAGAAAACCACGAACCATGAGTTTGTGGATGAACAAGTCTTTGAA
GAAAGCTGCATGGAAGTGGCCACTGTTAATCGCCCTTCAAGTCACAGCCCCTCCCTCTCT
TCCCAACAAGGAGTCACCAGCACTTGCTGCTCACGGAGACACAAAAAAACTTTCCGAATC
CCAAATGCCAATGTGTCAGGAAGTCATAGAGGCAGCGTGCAAGAACTCAGTACAATTCAG
ATCAGATGTGTGGAGAGAACTCCACTATCCAACAGCCGATCCAGCTTAAATGCCAAAATG
GAAGAGTGTGTCAAACTAAACTGTGAACAACCTTACGTGACCACAGCAATAATTAGCATT
CCAACACCTCCAGTAACCACCCCAGAAGGCGACGACAGGCCCGAGTCTCCTGAGTATTCG
GGAGGAAACATCGTCAGGGTGTCTGCTTTGTAA

• Ion_trans (PF00520 )
• K_tetra (PF02214 )
• Shal-type (PF11601 )

• None

• 184-204
• 225-245
• 260-280
• 290-310
• 324-344
• 385-405

>Potassium voltage-gated channel subfamily D member 2
MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLE
RYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELA
FFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGESALPTMTARQRVWRAFENPHT
STMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIF
TVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRI
FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAA
FWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD
KRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQHHH
LLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRI
PNANVSGSHQGSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISI
PTPPVTTPEGDDRPESPEYSGGNIVRVSAL

• 1NN7

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4. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ: Modulation of A-type potassium channels by a family of calcium sensors. Nature. 2000 Feb 3;403(6769):553-6. [PubMed:10676964 ]
5. Lin YL, Chen CY, Cheng CP, Chang LS: Protein-protein interactions of KChIP proteins and Kv4.2. Biochem Biophys Res Commun. 2004 Aug 27;321(3):606-10. [PubMed:15358149 ]
6. Scannevin RH, Wang K, Jow F, Megules J, Kopsco DC, Edris W, Carroll KC, Lu Q, Xu W, Xu Z, Katz AH, Olland S, Lin L, Taylor M, Stahl M, Malakian K, Somers W, Mosyak L, Bowlby MR, Chanda P, Rhodes KJ: Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. Neuron. 2004 Feb 19;41(4):587-98. [PubMed:14980207 ]
7. Bahring R, Dannenberg J, Peters HC, Leicher T, Pongs O, Isbrandt D: Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. J Biol Chem. 2001 Jun 29;276(26):23888-94. Epub 2001 Apr 3. [PubMed:11287421 ]
8. Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA: Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. J Biol Chem. 2004 Feb 13;279(7):5549-54. Epub 2003 Nov 17. [PubMed:14623880 ]
9. Kim LA, Furst J, Gutierrez D, Butler MH, Xu S, Goldstein SA, Grigorieff N: Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. Neuron. 2004 Feb 19;41(4):513-9. [PubMed:14980201 ]
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12. Zhu XR, Wulf A, Schwarz M, Isbrandt D, Pongs O: Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current. Receptors Channels. 1999;6(5):387-400. [PubMed:10551270 ]
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15. Schrader LA, Anderson AE, Mayne A, Pfaffinger PJ, Sweatt JD: PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. J Neurosci. 2002 Dec 1;22(23):10123-33. [PubMed:12451113 ]
16. Jerng HH, Qian Y, Pfaffinger PJ: Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). Biophys J. 2004 Oct;87(4):2380-96. [PubMed:15454437 ]
17. El-Haou S, Balse E, Neyroud N, Dilanian G, Gavillet B, Abriel H, Coulombe A, Jeromin A, Hatem SN: Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. Circ Res. 2009 Mar 27;104(6):758-69. doi: 10.1161/CIRCRESAHA.108.191007. Epub 2009 Feb 12. [PubMed:19213956 ]