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Identification
HMDB Protein ID HMDBP10974
Secondary Accession Numbers
  • 17288
Name Oxysterol-binding protein-related protein 2
Synonyms
  1. ORP-2
  2. OSBP-related protein 2
Gene Name OSBPL2
Protein Type Unknown
Biological Properties
General Function Involved in steroid metabolic process
Specific Function Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate
Pathways Not Available
Reactions Not Available
GO Classification
Process
metabolic process
primary metabolic process
lipid metabolic process
steroid metabolic process
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:2
Locus 20q13.3
SNPs OSBPL2
Gene Sequence
>1443 bp
ATGAACGGAGAGGAAGAATTCTTTGATGCCGTCACAGGCTTTGATTCTGATAACTCTTCT
GGGGAATTTTCAGAGGCAAATCAGAAAGTCACGGGAATGATTGACTTAGACACCAGCAAA
AATAATAGGATTGGGAAAACTGGGGAGAGGCCCTCTCAAGAGAACGGAATTCAGAAACAC
AGGACATCGCTGCCGGCTCCCATGTTCAGCAGAAGCGACTTCAGCGTGTGGACCATCCTG
AAGAAGTGTGTTGGCCTGGAGCTGTCCAAGATCACGATGCCAATCGCCTTCAACGAGCCT
CTGAGCTTCTTGCAGCGGATCACGGAGTACATGGAGCACGTGTACCTCATCCACAGGGCC
TCCTGCCAGCCCCAGCCCCTGGAGAGGATGCAGTCTGTGGCTGCTTTTGCTGTTTCGGCT
GTGGCTTCCCAGTGGGAGAGGACCGGCAAACCATTTAATCCACTCTTGGGAGAAACGTAT
GAATTAATCAGGGAAGATTTAGGATTCAGATTTATATCGGAACAGGTCAGTCACCACCCC
CCCATCAGTGCGTTCCACTCGGAAGGTCTCAACCATGACTTCCTGTTCCATGGCTCCATC
TACCCCAAGCTCAAGTTCTGGGGCAAAAGCGTGGAGGCGGAGCCCCGAGGCACCATCACC
CTGGAGCTGCTCAAACATAATGAAGCCTACACCTGGACCAACCCCACCTGCTGCGTCCAC
AACGTCATCATCGGGAAGCTGTGGATAGAGCAGTATGGGACAGTGGAGATTTTAAACCAC
AGAACTGGACATAAGTGTGTGCTTCACTTTAAACCGTGTGGATTATTTGGAAAAGAACTT
CACAAGGTGGAAGGACACATTCAAGACAAAAACAAAAAGAAGCTCTTTATGATCTATGGC
AAATGGACGGAATGTTTGTGGGGCATAGATCCTGTTTCGTATGAATCCTTCAAGAAGCAG
GAGAGGAGAGGTGACCACCTGAGAAAGGCCAAGCTGGATGAAGACTCCGGGAAGGCTGAC
AGCGACGTGGCTGACGACGTGCCTGTGGCCCAGGAGACCGTGCAGGTCATTCCTGGCAGC
AAGCTGCTCTGGAGGATCAACACCCGGCCCCCCAACTCTGCCCAGATGTATAATTTCACC
AGTTTCACTGTGAGCCTCAACGAGCTGGAGACAGGCATGGAGAAGACCCTGCCACCCACG
GACTGCCGCCTGCGCCCTGACATCCGCGGCATGGAGAATGGCAACATGGATCTGGCCAGC
CAGGAGAAGGAGCGGCTGGAGGAGAAGCAGAGAGAAGCACGGAGGGAGCGGGCCAAGGAG
GAGGCAGAGTGGCAGACGAGGTGGTTCTACCCAGGCAATAACCCCTACACTGGGACCCCC
GACTGGTTGTATGCAGGGGATTACTTTGAGCGGAATTTCTCCGACTGCCCAGATATCTAC
TGA
Protein Properties
Number of Residues 480
Molecular Weight 55200.9
Theoretical pI 6.31
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Oxysterol-binding protein-related protein 2
MNGEEEFFDAVTGFDSDNSSGEFSEANQKVTGMIDLDTSKNNRIGKTGERPSQENGIQKH
RTSLPAPMFSRSDFSVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHRA
SCQPQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHP
PISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVH
NVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKELHKVEGHIQDKNKKKLFMIYG
KWTECLWGIDPVSYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVAQETVQVIPGS
KLLWRINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENGNMDLAS
QEKERLEEKQREARRERAKEEAEWQTRWFYPGNNPYTGTPDWLYAGDYFERNFSDCPDIY
GenBank ID Protein 21450853
UniProtKB/Swiss-Prot ID Q9H1P3
UniProtKB/Swiss-Prot Entry Name OSBL2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_144498.1
GeneCard ID OSBPL2
GenAtlas ID OSBPL2
HGNC ID HGNC:15761
References
General References
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  4. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1998 Oct 30;5(5):277-86. [PubMed:9872452 ]
  5. Xu Y, Liu Y, Ridgway ND, McMaster CR: Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport. J Biol Chem. 2001 May 25;276(21):18407-14. Epub 2001 Feb 26. [PubMed:11279184 ]
  6. Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR: A family of 12 human genes containing oxysterol-binding domains. Genomics. 2001 Dec;78(3):185-96. [PubMed:11735225 ]
  7. Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM: The OSBP-related protein family in humans. J Lipid Res. 2001 Aug;42(8):1203-13. [PubMed:11483621 ]