Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP11476
Secondary Accession Numbers
  • 17825
Name FERM, RhoGEF and pleckstrin domain-containing protein 2
Synonyms
  1. FERM domain including RhoGEF
  2. FIR
  3. PH domain-containing family C member 3
  4. Pleckstrin homology domain-containing family C member 3
Gene Name FARP2
Protein Type Unknown
Biological Properties
General Function Involved in Rho guanyl-nucleotide exchange factor activity
Specific Function Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular part
cytoplasm
cytoskeleton
membrane part
organelle
extrinsic to membrane
intracellular
non-membrane-bounded organelle
intracellular non-membrane-bounded organelle
Function
small gtpase regulator activity
binding
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
enzyme regulator activity
protein binding
cytoskeletal protein binding
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of ras protein signal transduction
regulation of rho protein signal transduction
biological regulation
regulation of biological process
regulation of cellular process
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:2
Locus 2q37.3
SNPs FARP2
Gene Sequence
>3165 bp
ATGGGGGAGATAGAAGGAACATACAGAGTCCTGCAGACTGCAGGGATGCGCTTGGGTGCC
CAGACCCCTGTGGGAGTTAGCACCCTTGAGCCTGGGCAGACTCTCTTGCCCAGAATGCAA
GAGAAGCACCTGCACCTCAGAGTAAAGCTGCTGGACAACACCATGGAAATATTTGACATT
GAGCCTAAATGCGATGGCCAGGTATTACTGACACAAGTGTGGAAGCGTTTAAACCTGGTA
GAATGTGACTACTTCGGGATGGAGTTTCAAAATACTCAGTCCTACTGGATTTGGCTTGAA
CCTATGAAACCCATCATTAGGCAAATACGAAGGCCAAAGAATGTGGTGCTTCGCCTAGCT
GTAAAATTTTTTCCACCTGATCCTGGTCAGCTACAAGAAGAATATACAAGATACTTGTTT
GCCTTGCAACTTAAGAGAGACCTGCTGGAAGAGCGTTTGACCTGTGCTGACACCACAGCG
GCCCTTCTCACGTCCCATCTCCTGCAGTCGGAAATAGGAGATTACGATGAAACGCTGGAC
CGAGAGCACCTCAAAGTGAACGAGTATTTGCCTGGCCAGCAGCACTGCCTTGAGAAGATA
CTAGAATTCCATCAGAAGCACGTGGGCCAGACACCTGCTGAGTCGGATTTCCAGGTGCTC
GAAATTGCTCGAAAGTTGGAAATGTACGGCATCAGATTTCACATGGCTTCTGACAGGGAA
GGAACCAAGATTCAACTGGCAGTTTCCCACATGGGTGTACTCGTGTTCCAGGGCACCACC
AAAATCAACACTTTCAACTGGTCCAAGGTCCGTAAACTAAGCTTCAAGAGGAAAAGATTT
CTTATCAAACTTCATCCAGAGGTTCATGGACCTTACCAGGACACATTAGAATTTTTGTTG
GGTAGTAGAGATGAATGTAAGAACTTCTGGAAGATTTGTGTGGAGTATCACACCTTTTTT
AGACTTTTGGACCAACCTAAGCCAAAAGCAAAAGCCGTCTTCTTCAGCCGGGGCTCCTCC
TTCAGATACAGTGGAAGAACTCAGAAACAACTAGTAGATTATTTCAAAGACAGTGGAATG
AAGAGAATTCCATATGAAAGAAGGCACAGCAAGACCCACACGTCCGTTCGAGCTCTGACT
GCAGACCTACCAAAACAGAGCATCTCATTCCCCGAGGGATTGAGGACTCCTGCCTCCCCA
TCTTCAGCGAATGCCTTTTACTCGCTCTCTCCCTCCACTCTGGTCCCCTCTGGCCTGCCA
GAGTTTAAGGACAGCAGCAGCTCCCTCACAGATCCCCAGGTTTCCTACGTCAAGAGTCCA
GCTGCAGAGAGGCGCAGTGGAGCAGTGGCTGGAGGCCCCGACACACCATCGGCCCAGCCC
CTCGGGCCCCCCGCACTCCAGCCTGGTCCAGGCCTTTCCACGAAGAGTCCTCAGCCTTCT
CCCTCCAGCCGGAAGAGCCCCCTGAGTCTGAGCCCTGCATTTCAGGTGCCTTTGGGCCCA
GCTGAACAGGGCTCATCCCCACTCCTGAGCCCTGTCCTCAGTGATGCTGGCGGAGCCGGG
ATGGACTGCGAGGAGCCCAGACACAAGCGCGTGCCTGCAGACGAGGCCTACTTCATAGTC
AAAGAGATTCTCGCTACAGAACGAACATACCTCAAGGATTTAGAAGTTATTACCGTGTGG
TTCCGCAGCGCAGTGGTGAAGGAGGACGCCATGCCTGCGACTCTGATGACGCTGCTCTTC
TCCAACATCGATCCCATCTATGAGTTCCACAGAGGCTTCCTGCGCGAGGTGGAGCAGAGG
CTGGCACTCTGGGAAGGGCCCTCCAAAGCCCACACAAAAGGCAGTCATCAACGAATCGGG
GACATCCTGCTCAGGAACATGCGCCAGTTAAAGGAGTTTACCAGCTACTTCCAAAGACAT
GACGAGGTCCTAACAGAACTGGAAAAGGCTACCAAACGCTGTAAGAAGTTGGAGGCAGTG
TACAAGGAGTTTGAGCTGCAGAAGGTCTGCTACTTGCCTCTCAACACGTTCCTGCTGAAG
CCCATCCAGCGGCTGCTGCACTACCGCCTGCTGCTGCGCCGCCTATGCGGACATTACAGC
CCCGGGCACCATGACTACGCTGACTGCCATGACGCCCTGAAAGCCATCACAGAGGTGACC
ACCACACTACAGCACATTCTCATCCGGCTGGAGAACCTGCAGAAGCTAACGGAGCTGCAG
CGGGACCTGGTGGGCATAGAGAACCTCATTGCTCCTGGCAGGGAGTTCATCCGTGAGGGC
TGCCTTCACAAGCTCACCAAGAAGGGCCTGCAGCAGAGGATGTTTTTTCTGTTCTCAGAT
ATGTTGCTGTACACAAGCAAAGGAGTTGCAGGGACCAGCCACTTCCGGATCCGGGGCCTC
CTTCCCCTCCAAGGCATGCTGGTGGAAGAAAGTGATAACGAGTGGTCTGTTCCACACTGT
TTCACCATCTACGCGGCTCAGAAAACAATCGTGGTGGCAGCCAGCACTCGGCTGGAGAAA
GAGAAGTGGATGCTGGACCTGAACTCCGCGATCCAAGCAGCCAAGAGTGGCGGTGACACG
GCCCCTGCACTGCCAGGCCGCACTGTGTGCACTCGTCCCCCCAGATCCCCCAACGAGGTA
TCTCTGGAGCAGGAGTCAGAAGATGATGCTCGGGGTGTCCGCAGCTCCCTGGAGGGGCAT
GGCCAGCACCGGGCCAACACCACAATGCACGTGTGCTGGTACCGGAACACCAGCGTGTCC
AGGGCAGACCACAGTGCAGCTGTCGAGAACCAGCTTTCAGGATATCTGCTAAGAAAGTTC
AAAAACAGTCATGGCTGGCAGAAGCTCTGGGTCGTCTTTACCAACTTCTGTTTGTTCTTC
TACAAAACTCATCAGGATGACTACCCACTGGCCAGCCTCCCGCTGCTGGGCTACAGCGTG
AGCATCCCCAGGGAGGCCGATGGCATACACAAAGACTATGTTTTCAAGCTCCAGTTCAAA
TCCCACGTCTACTTCTTCCGGGCTGAGAGCAAGTACACATTTGAAAGGTGGATGGAGGTG
ATCCAGGGGGCCAGCAGCTCAGCCGGGAGGGCCCCAAGCATCGTGCAGGATGGCCCCCAA
CCCTCCTCAGGGCTGGAGGGGATGGTCAGGGGGAAGGAGGAATGA
Protein Properties
Number of Residues 1054
Molecular Weight 119887.5
Theoretical pI 9.05
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>FERM, RhoGEF and pleckstrin domain-containing protein 2
MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDI
EPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLA
VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLD
REHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDRE
GTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL
GSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGM
KRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLP
EFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPS
PSSRKSPLSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIV
KEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQR
LALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAV
YKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVT
TTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSD
MLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEK
EKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGH
GQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFF
YKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEV
IQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE
GenBank ID Protein 7662310
UniProtKB/Swiss-Prot ID O94887
UniProtKB/Swiss-Prot Entry Name FARP2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_014808.2
GeneCard ID FARP2
GenAtlas ID FARP2
HGNC ID HGNC:16460
References
General References
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  4. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
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