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Identification
HMDB Protein ID HMDBP11492
Secondary Accession Numbers
  • 17843
Name Prolactin regulatory element-binding protein
Synonyms
  1. Mammalian guanine nucleotide exchange factor mSec12
Gene Name PREB
Protein Type Unknown
Biological Properties
General Function Involved in DNA binding
Specific Function Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Nucleus
  2. Endoplasmic reticulum membrane
  3. Single-pass membrane protein
Gene Properties
Chromosome Location Chromosome:2
Locus 2p23.3
SNPs PREB
Gene Sequence
>1254 bp
ATGGGCCGGCGCCGGGCGCCAGAGCTGTACCGGGCTCCGTTCCCGTTGTACGCGCTTCAG
GTCGACCCCAGCACTGGGCTGCTCATCGCTGCGGGCGGAGGAGGCGCCGCCAAGACAGGC
ATAAAGAATGGCGTGCACTTTCTGCAGCTAGAGCTGATTAATGGGCGCTTGAGTGCCTCC
TTGCTGCACTCCCATGACACAGAGACACGGGCCACCATGAACTTGGCACTGGCTGGTGAC
ATCCTTGCTGCAGGGCAGGATGCACACTGTCAGCTCCTGCGCTTCCAGGCACATCAACAG
CAGGGCAACAAGGCAGAGAAGGCCGGTTCCAAGGAGCAGGGGCCTCGACAAAGGAAGGGA
GCAGCCCCAGCAGAGAAGAAATGTGGAGCGGAAACCCAGCACGAGGGGCTAGAACTCAGG
GTAGAGAATTTGCAGGCGGTGCAGACAGACTTTAGCTCCGATCCACTGCAGAAAGTTGTG
TGCTTCAACCACGATAATACCCTGCTTGCCACTGGAGGAACAGATGGCTACGTCCGTGTC
TGGAAGGTGCCCAGCCTGGAGAAGGTTCTGGAGTTCAAAGCCCACGAAGGGGAGATTGAA
GACCTGGCTTTAGGGCCTGATGGCAAGTTGGTAACCGTGGGCCGGGACCTTAAGGCCTCT
GTGTGGCAGAAGGATCAGCTGGTGACACAGCTGCACTGGCAAGAAAATGGACCCACCTTT
TCCAGCACACCTTACCGCTACCAGGCCTGCAGGTTTGGGCAGGTTCCAGACCAGCCTGCT
GGCCTGCGACTCTTCACAGTGCAAATTCCCCACAAGCGGCTGCGGCAGCCCCCTCCCTGC
TACCTCACAGCCTGGGATGGCTCCAACTTCTTGCCCCTTCGGACCAAGTCCTGTGGCCAT
GAAGTCGTCTCCTGCCTCGATGTCAGTGAATCCGGCACCTTCCTAGGCCTGGGCACAGTC
ACTGGCTCTGTTGCCATCTACATAGCTTTCTCTCTCCAGTGCCTCTACTACGTGAGGGAG
GCCCATGGCATTGTGGTGACGGATGTGGCCTTTCTACCTGAGAAGGGTCGTGGTCCAGAG
CTCCTTGGGTCCCATGAAACTGCCCTGTTCTCTGTGGCTGTGGACAGTCGTTGCCAGCTG
CATCTGTTGCCCTCACGGCGGAGTGTTCCTGTGTGGCTCCTGCTCCTGCTGTGTGTCGGG
CTTATTATTGTGACCATCCTGCTGCTCCAGAGTGCCTTTCCAGGTTTCCTTTAG
Protein Properties
Number of Residues 417
Molecular Weight 45467.8
Theoretical pI 7.95
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 389-409
Protein Sequence
>Prolactin regulatory element-binding protein
MGRRRAPELYRAPFPLYALQVDPSTGLLIAAGGGGAAKTGIKNGVHFLQLELINGRLSAS
LLHSHDTETRATMNLALAGDILAAGQDAHCQLLRFQAHQQQGNKAEKAGSKEQGPRQRKG
AAPAEKKCGAETQHEGLELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRV
WKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKASVWQKDQLVTQLHWQENGPTF
SSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYLTAWDGSNFLPLRTKSCGH
EVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPE
LLGSHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIIVTILLLQSAFPGFL
GenBank ID Protein 6606522
UniProtKB/Swiss-Prot ID Q9HCU5
UniProtKB/Swiss-Prot Entry Name PREB_HUMAN
PDB IDs Not Available
GenBank Gene ID AF203687
GeneCard ID PREB
GenAtlas ID PREB
HGNC ID HGNC:9356
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Taylor Clelland CL, Levy B, McKie JM, Duncan AM, Hirschhorn K, Bancroft C: Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome. Mamm Genome. 2000 Aug;11(8):675-81. [PubMed:10920239 ]
  4. Edgar AJ: The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12. BMC Genomics. 2003 May 7;4(1):18. Epub 2003 May 7. [PubMed:12735795 ]