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Identification
HMDB Protein ID HMDBP11551
Secondary Accession Numbers
  • 20995
Name Carboxypeptidase N subunit 2
Synonyms
  1. Carboxypeptidase N 83 kDa chain
  2. Carboxypeptidase N large subunit
  3. Carboxypeptidase N polypeptide 2
  4. Carboxypeptidase N regulatory subunit
Gene Name CPN2
Protein Type Enzyme
Biological Properties
General Function Involved in protein binding
Specific Function The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
protein binding
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Chromosome:3
Locus 3q29
SNPs CPN2
Gene Sequence
>1638 bp
ATGCTCCCTGGAGCCTGGCTGCTCTGGACCTCCCTCCTGCTCCTGGCCAGGCCTGCCCAG
CCCTGTCCCATGGGTTGTGACTGCTTCGTCCAGGAGGTGTTCTGCTCAGATGAGGAGCTT
GCCACCGTCCCGCTGGACATCCCGCCATATACGAAAAACATCATCTTTGTGGAGACCTCG
TTCACCACATTGGAAACCAGAGCTTTTGGCAGTAACCCCAACTTGACCAAGGTGGTCTTC
CTCAACACTCAGCTCTGCCAGTTTAGGCCGGATGCCTTTGGGGGGCTGCCCAGGCTGGAG
GACCTGGAGGTCACAGGCAGTAGCTTCTTGAACCTCAGCACCAACATCTTCTCCAACCTG
ACCTCGCTGGGCAAGCTCACCCTCAACTTCAACATGCTGGAGGCTCTGCCCGAGGGTCTT
TTCCAGCACCTGGCTGCCCTGGAGTCCCTCCACCTGCAGGGGAACCAGCTCCAGGCCCTG
CCCAGGAGGCTCTTCCAGCCTCTGACCCATCTGAAGACACTCAACCTGGCCCAGAACCTC
CTGGCCCAGCTCCCGGAGGAGCTGTTCCACCCACTCACCAGCCTGCAGACCCTGAAGCTG
AGCAACAACGCGCTCTCTGGTCTCCCCCAGGGTGTGTTTGGCAAACTGGGCAGCCTGCAG
GAGCTCTTCCTGGACAGCAACAACATCTCGGAGCTGCCCCCTCAGGTGTTCTCCCAGCTC
TTCTGCCTAGAGAGGCTGTGGCTGCAACGCAACGCCATCACGCACCTGCCGCTCTCCATC
TTTGCCTCCCTGGGTAATCTGACCTTTCTGAGCTTGCAGTGGAACATGCTTCGGGTCCTG
CCTGCCGGCCTCTTTGCCCACACCCCATGCCTGGTTGGCCTGTCTCTGACCCATAACCAG
CTGGAGACTGTCGCTGAGGGCACCTTTGCCCACCTGTCCAACCTGCGTTCCCTCATGCTC
TCATACAATGCCATTACCCACCTCCCAGCTGGCATCTTCAGAGACCTGGAGGAGTTGGTC
AAACTCTACCTGGGCAGCAACAACCTTACGGCGCTGCACCCAGCCCTCTTCCAGAACCTG
TCCAAGCTGGAGCTGCTCAGCCTCTCCAAGAACCAGCTGACCACACTTCCGGAGGGCATC
TTCGACACCAACTACAACCTGTTCAACCTGGCCCTGCACGGTAACCCCTGGCAGTGCGAC
TGCCACCTGGCCTACCTCTTCAACTGGCTGCAGCAGTACACCGATCGGCTCCTGAACATC
CAGACCTACTGCGCTGGCCCTGCCTACCTCAAAGGCCAGGTGGTGCCCGCCTTGAATGAG
AAGCAGCTGGTGTGTCCCGTCACCCGGGACCACTTGGGCTTCCAGGTCACGTGGCCGGAC
GAAAGCAAGGCAGGGGGCAGCTGGGATCTGGCTGTGCAGGAAAGGGCAGCCCGGAGCCAG
TGCACCTACAGCAACCCCGAGGGCACCGTGGTGCTCGCCTGTGACCAGGCCCAGTGTCGC
TGGCTGAACGTCCAGCTCTCTCCTCGGCAGGGCTCCCTGGGACTGCAGTACAATGCTAGT
CAGGAGTGGGACCTGAGGTCGAGCTGCGGTTCTCTGCGGCTCACCATGTCTATCGAGGCT
CGGGCAGCAGGGCCCTAG
Protein Properties
Number of Residues 545
Molecular Weight 60614.1
Theoretical pI 5.89
Pfam Domain Function
Signals
  • 1-21
Transmembrane Regions
  • None
Protein Sequence
>Carboxypeptidase N subunit 2
MLPGAWLLWTSLLLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETS
FTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNL
TSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL
LAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQL
FCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQ
LETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNL
SKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNI
QTYCAGPAYLKGQVVPALNEKQLVCPVTRDHLGFQVTWPDESKAGGSWDLAVQERAARSQ
CTYSNPEGTVVLACDQAQCRWLNVQLSPWQGSLGLQYNASQEWDLRSSCGSLRLTVSIEA
RAAGP
GenBank ID Protein 51173528
UniProtKB/Swiss-Prot ID P22792
UniProtKB/Swiss-Prot Entry Name CPN2_HUMAN
PDB IDs Not Available
GenBank Gene ID J05158
GeneCard ID CPN2
GenAtlas ID CPN2
HGNC ID HGNC:2313
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J Proteome Res. 2005 Nov-Dec;4(6):2070-80. [PubMed:16335952 ]
  3. Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wisniewski JR: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. Proteomics. 2004 Feb;4(2):454-65. [PubMed:14760718 ]
  4. Skidgel RA, Bennett CD, Schilling JW, Tan FL, Weerasinghe DK, Erdos EG: Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases. Biochem Biophys Res Commun. 1988 Aug 15;154(3):1323-9. [PubMed:3408501 ]
  5. Tan F, Weerasinghe DK, Skidgel RA, Tamei H, Kaul RK, Roninson IB, Schilling JW, Erdos EG: The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats. J Biol Chem. 1990 Jan 5;265(1):13-9. [PubMed:2378615 ]