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Identification
HMDB Protein ID HMDBP11573
Secondary Accession Numbers
  • 21017
Name Tyrosine-protein phosphatase non-receptor type 23
Synonyms
  1. HD-PTP
  2. His domain-containing protein tyrosine phosphatase
  3. PTP-TD14
  4. Protein tyrosine phosphatase TD14
Gene Name PTPN23
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
Pathways Not Available
Reactions
Protein tyrosine phosphate + Water → protein tyrosine + Phosphate details
GO Classification
Biological Process
cilium morphogenesis
peptidyl-tyrosine dephosphorylation
Cellular Component
cilium
nucleus
microtubule basal body
cytoplasmic membrane-bounded vesicle
endosome
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
Molecular Function
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Cytoplasmic vesicle
Gene Properties
Chromosome Location 3
Locus 3p21.3
SNPs PTPN23
Gene Sequence
>4911 bp
ATGGAGGCCGTGCCCCGCATGCCCATGATCTGGCTGGACCTGAAGGAGGCCGGTGACTTT
CACTTCCAGCCAGCTGTGAAGAAGTTCGTCCTGAAGAATTATGGAGAGAACCCAGAAGCC
TACAATGAAGAACTGAAGAAGCTGGAGTTGCTCAGACAGAATGCTGTCCGTGTCCCACGA
GACTTTGAGGGCTGTAGTGTCCTCCGCAAGTACCTCGGCCAGCTTCATTACCTGCAGAGT
CGGGTCCCCATGGGCTCGGGCCAGGAGGCCGCTGTCCCTGTCACCTGGACAGAGATCTTC
TCAGGCAAGTCTGTGGCCCATGAGGACATCAAGTACGAGCAGGCCTGTATTCTCTACAAC
CTTGGAGCGCTGCACTCCATGCTGGGGGCCATGGACAAGCGGGTGTCTGAGGAGGGCATG
AAGGTCTCCTGTACCCATTTCCAGTGCGCAGCCGGCGCCTTCGCCTACCTACGGGAGCAC
TTCCCTCAAGCCTACAGCGTCGACATGAGCCGCCAGATCCTTACGCTCAACGTCAACCTC
ATGCTGGGCCAGGCTCAGGAGTGCCTCCTGGAGAAGTCGATGTTGGACAACAGGAAGAGC
TTTCTGGTGGCCCGCATCAGTGCACAGGTGGTAGATTACTACAAGGAGGCATGCCGGGCC
TTGGAGAACCCCGACACTGCCTCACTGCTGGGCCGGATCCAGAAGGACTGGAAGAAACTT
GTGCAGATGAAGATCTACTACTTCGCAGCCGTGGCTCATCTGCACATGGGAAAGCAGGCC
GAGGAGCAGCAGAAGTTCGGGGAGCGGGTTGCATACTTCCAGAGCGCCCTGGACAAGCTC
AATGAAGCCATCAAGTTGGCCAAGGGCCAGCCTGACACTGTGCAAGACGCGCTTCGCTTC
ACTATGGATGTCATTGGGGGAAAGTACAATTCTGCCAAGAAGGACAACGACTTCATTTAC
CATGAGGCTGTCCCAGCATTGGACACCCTTCAGCCTGTAAAAGGAGCCCCCTTGGTGAAG
CCCTTGCCAGTGAACCCCACAGACCCAGCTGTTACAGGCCCTGACATCTTTGCCAAACTG
GTACCCATGGCTGCCCACGAGGCCTCGTCACTGTACAGTGAGGAGAAGGCCAAGCTGCTC
CGGGAGATGATGGCCAAGATTGAGGACAAGAATGAGGTCCTGGACCAGTTCATGGATTCA
ATGCAGTTGGATCCCGAGACGGTGGACAACCTTGATGCCTACAGCCACATCCCACCCCAG
CTCATGGAGAAGTGCGCGGCTCTCAGCGTCCGGCCCGACACTGTCAGGAACCTTGTACAG
TCCATGCAAGTGCTGTCAGGTGTGTTCACGGATGTGGAGGCTTCCCTGAAGGACATCAGA
GATCTGTTGGAGGAGGATGAGCTGCTAGAGCAGAAGTTTCAGGAGGCGGTGGGCCAGGCA
GGGGCCATCTCCATCACCTCCAAGGCTGAGCTGGCAGAGGTGAGGCGAGAATGGGCCAAG
TACATGGAAGTCCATGAGAAGGCCTCCTTCACCAACAGTGAGCTGCACCGTGCCATGAAC
CTGCACGTCGGCAACCTGCGCCTGCTCAGCGGGCCGCTTGACCAGGTCCGGGCTGCCCTG
CCCACACCGGCCCTCTCCCCAGAGGACAAGGCCGTGCTGCAAAACCTAAAGCGCATCCTG
GCTAAGGTGCAGGAGATGCGGGACCAGCGCGTGTCCCTGGAGCAGCAGCTGCGTGAGCTT
ATCCAGAAAGATGACATCACTGCCTCGCTGGTCACCACAGACCACTCAGAGATGAAGAAG
TTGTTCGAGGAGCAGCTGAAAAAGTATGACCAGCTGAAGGTGTACCTGGAGCAGAACCTG
GCCGCCCAGGACCGTGTCCTCTGTGCACTGACAGAGGCCAACGTGCAGTACGCAGCCGTG
CGGCGGGTACTCAGCGACTTGGACCAAAAGTGGAACTCCACGCTGCAGACCCTGGTGGCC
TCGTATGAAGCCTATGAGGACCTGATGAAGAAGTCGCAGGAGGGCAGGGACTTCTACGCA
GATCTGGAGAGCAAGGTGGCTGCTCTGCTGGAGCGCACGCAGTCCACCTGCCAGGCCCGC
GAGGCTGCCCGCCAGCAGCTCCTGGACAGGGAGCTGAAGAAGAAGCCGCCGCCACGGCCC
ACAGCCCCAAAGCCGCTGCTGCCCCGCAGGGAGGAGAGTGAGGCAGTGGAAGCAGGAGAC
CCCCCTGAGGAGCTGCGCAGCCTCCCCCCTGACATGGTGGCTGGCCCACGACTGCCTGAC
ACCTTCCTGGGAAGTGCCACCCCGCTCCACTTTCCTCCCAGCCCCTTCCCCAGCTCCACA
GGCCCAGGACCCCACTATCTCTCAGGCCCCTTGCCCCCTGGTACCTACTCGGGCCCCACC
CAGCTGATACAGCCCAGGGCCCCAGGGCCCCATGCAATGCCCGTAGCACCTGGGCCTGCC
CTCTACCCAGCCCCTGCATACACACCGGAGCTGGGCCTTGTGCCCCGATCCTCCCCACAG
CATGGCGTGGTGAGCAGTCCCTATGTGGGGGTAGGGCCGGCCCCACCAGTTGCAGGTCTC
CCCTCGGCCCCACCTCCTCAATTCTCAGGCCCCGAGTTGGCCATGGCGGTTCGGCCAGCC
ACCACCACAGTAGATAGCATCCAGGCGCCCATCCCCAGCCACACAGCCCCACGGCCAAAC
CCCACCCCTGCTCCTCCCCCGCCCTGCTTCCCTGTGCCCCCACCGCAGCCACTGCCCACG
CCTTACACCTACCCTGCAGGGGCTAAGCAACCCATCCCAGCACAGCACCACTTCTCTTCT
GGGATCCCCGCAGGTTTTCCAGCCCCAAGGATTGGGCCCCAGCCCCAGCCCCATCCTCAG
CCCCATCCTTCACAAGCGTTTGGGCCTCAGCCCCCACAGCAGCCCCTTCCACTCCAGCAT
CCACATCTCTTCCCACCCCAGGCCCCAGGACTCCTACCCCCACAATCCCCCTACCCCTAT
GCCCCTCAGCCTGGGGTCCTGGGGCAGCCGCCACCCCCCCTACACACCCAGCTCTACCCA
GGTCCCGCTCAAGACCCTCTGCCAGCCCACTCAGGGGCTCTGCCTTTCCCCAGCCCTGGG
CCCCCTCAGCCTCCCCATCCCCCACTGGCATATGGTCCTGCCCCTTCTACCAGACCCATG
GGCCCCCAGGCAGCCCCTCTTACCATTCGAGGGCCCTCGTCTGCTGGCCAGTCCACCCCT
AGTCCCCACCTGGTGCCTTCACCTGCCCCATCTCCAGGGCCTGGTCCGGTACCCCCTCGC
CCCCCAGCAGCAGAACCACCCCCTTGCCTGCGCCGAGGCGCCGCAGCTGCAGACCTGCTC
TCCTCCAGCCCGGAGAGCCAGCATGGCGGCACTCAGTCTCCTGGGGGTGGGCAGCCCCTG
CTGCAGCCCACCAAGGTGGATGCAGCTGAGGGTCGTCGGCCGCAGGCCCTGCGGCTGATT
GAGCGGGACCCCTATGAGCATCCTGAGAGGCTGCGGCAGTTGCAGCAGGAGCTGGAGGCC
TTTCGGGGTCAGCTGGGGGATGTGGGAGCTCTGGACACTGTCTGGCGAGAGCTGCAAGAT
GCGCAGGAACATGATGCCCGAGGCCGTTCCATCGCCATTGCCCGCTGCTACTCACTGAAG
AACCGGCACCAGGATGTCATGCCCTATGACAGTAACCGTGTGGTGCTGCGCTCAGGCAAG
GATGACTACATCAATGCCAGCTGCGTGGAGGGGCTCTCCCCATACTGCCCCCCGCTAGTG
GCAACCCAGGCCCCACTGCCTGGCACAGCTGCTGACTTCTGGCTCATGGTCCATGAGCAG
AAAGTGTCAGTCATTGTCATGCTGGTTTCTGAGGCTGAGATGGAGAAGCAAAAAGTGGCA
CGCTACTTCCCCACCGAGAGGGGCCAGCCCATGGTGCACGGTGCCCTGAGCCTGGCATTG
AGCAGCGTCCGCAGCACCGAAACCCATGTGGAGCGCGTGCTGAGCCTGCAGTTCCGAGAC
CAGAGCCTCAAGCGCTCTCTTGTGCACCTGCACTTCCCCACTTGGCCTGAGTTAGGCCTG
CCCGACAGCCCCAGCAACTTGCTGCGCTTCATCCAGGAGGTGCACGCACATTACCTGCAT
CAGCGGCCGCTGCACACGCCCATCATTGTGCACTGCAGCTCTGGTGTGGGCCGCACGGGA
GCCTTTGCACTGCTCTATGCAGCTGTGCAGGAGGTGGAGGCTGGGAACGGAATCCCTGAG
CTGCCTCAGCTGGTGCGGCGCATGCGGCAGCAGAGAAAGCACATGCTGCAGGAGAAGCTG
CACCTCAGGTTCTGCTATGAGGCAGTGGTGAGACACGTGGAGCAGGTCCTGCAGCGCCAT
GGTGTGCCTCCTCCATGCAAACCCTTGGCCAGTGCAAGCATCAGCCAGAAGAACCACCTT
CCTCAGGACTCCCAGGACCTGGTCCTCGGTGGGGATGTGCCCATCAGCTCCATCCAGGCC
ACCATTGCCAAGCTCAGCATTCGGCCTCCTGGGGGGTTGGAGTCCCCGGTTGCCAGCTTG
CCAGGCCCTGCAGAGCCCCCAGGCCTCCCGCCAGCCAGCCTCCCAGAGTCTACCCCAATC
CCATCTTCCTCCCCACCCCCCCTTTCCTCCCCACTACCTGAGGCTCCCCAGCCTAAGGAG
GAGCCGCCAGTGCCTGAAGCCCCCAGCTCGGGGCCCCCCTCCTCCTCCCTGGAATTGCTG
GCCTCCTTGACCCCAGAGGCCTTCTCCCTGGACAGCTCCCTGCGGGGCAAACAGCGGATG
AGCAAGCATAACTTTCTGCAGGCCCATAACGGGCAAGGGCTGCGGGCCACCCGGCCCTCT
GACGACCCCCTCAGCCTTCTGGATCCACTCTGGACACTCAACAAGACCTGA
Protein Properties
Number of Residues 1636
Molecular Weight 178971.945
Theoretical pI 6.918
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Tyrosine-protein phosphatase non-receptor type 23
MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPR
DFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYN
LGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNL
MLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKL
VQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRF
TMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKL
VPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQ
LMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQA
GAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAAL
PTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKK
LFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVA
SYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRP
TAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSST
GPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQ
HGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPN
PTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQ
PHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYP
GPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTP
SPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPL
LQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQD
AQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLV
ATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLAL
SSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLH
QRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKL
HLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQA
TIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKE
EPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPS
DDPLSLLDPLWTLNKT
GenBank ID Protein 11862816
UniProtKB/Swiss-Prot ID Q9H3S7
UniProtKB/Swiss-Prot Entry Name PTN23_HUMAN
PDB IDs
GenBank Gene ID AB025194
GeneCard ID PTPN23
GenAtlas ID PTPN23
HGNC ID HGNC:14406
References
General References
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  5. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. [PubMed:17525332 ]
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  7. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  8. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Apr 28;7(2):143-50. [PubMed:10819331 ]
  9. Toyooka S, Ouchida M, Jitsumori Y, Tsukuda K, Sakai A, Nakamura A, Shimizu N, Shimizu K: HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3. Biochem Biophys Res Commun. 2000 Nov 30;278(3):671-8. [PubMed:11095967 ]