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Identification
HMDB Protein ID HMDBP11578
Secondary Accession Numbers
  • 21022
Name 14 kDa phosphohistidine phosphatase
Synonyms
  1. Phosphohistidine phosphatase 1
  2. Protein janus-A homolog
Gene Name PHPT1
Protein Type Enzyme
Biological Properties
General Function Involved in phosphohistidine phosphatase activity
Specific Function Exhibits phosphohistidine phosphatase activity.
Pathways
  • Fructose and Mannose Degradation
  • Fructose and mannose metabolism
  • Fructose intolerance, hereditary
  • Fructosuria
Reactions
NADP + Water → Phosphoric acid + NAD details
Beta-D-Fructose 2-phosphate + Water → D-Fructose + Phosphoric acid details
N-Acetylmannosamine + Phosphoric acid → N-Acetyl-D-mannosamine 6-phosphate + Water details
GO Classification
Biological Process
negative regulation of ATP citrate synthase activity
negative regulation of lyase activity
peptidyl-histidine dephosphorylation
regulation of actin cytoskeleton reorganization
positive regulation of cell motility
negative regulation of T cell receptor signaling pathway
Cellular Component
cytosol
Molecular Function
phosphoprotein phosphatase activity
phosphohistidine phosphatase activity
calcium channel inhibitor activity
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs PHPT1
Gene Sequence
>378 bp
ATGGCGGTGGCGGACCTCGCTCTCATTCCTGATGTGGACATCGACTCCGACGGCGTCTTC
AAGTATGTGCTGATCCGAGTCCACTCGGCTCCCCGCTCCGGGGCTCCGGCTGCAGAGAGC
AAGGAGATCGTGCGCGGCTACAAGTGGGCTGAGTACCATGCGGACATCTACGACAAAGTG
TCGGGCGACATGCAGAAGCAAGGCTGCGACTGTGAGTGTCTGGGCGGCGGGCGCATCTCC
CACCAGAGTCAGGACAAGAAGATTCACGTGTACGGCTATTCCATGGCCTATGGTCCTGCC
CAGCACGCCATTTCAACTGAGAAAATCAAAGCCAAGTACCCCGACTACGAGGTCACCTGG
GCTAACGACGGCTACTGA
Protein Properties
Number of Residues 125
Molecular Weight Not Available
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>14 kDa phosphohistidine phosphatase
MAVADLALIPDVDIDSDGVFKYVLIRVHSAPRSGAPAAESKEIVRGYKWAEYHADIYDKV
SGDMQKQGCDCECLGGGRISHQSQDKKIHVYGYSMAYGPAQHAISTEKIKAKYPDYEVTW
ANDGY
GenBank ID Protein 8895093
UniProtKB/Swiss-Prot ID Q9NRX4
UniProtKB/Swiss-Prot Entry Name PHP14_HUMAN
PDB IDs
GenBank Gene ID AF164795
GeneCard ID PHPT1
GenAtlas ID PHPT1
HGNC ID HGNC:30033
References
General References
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  5. Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG 2nd, Smith RD, Wiley HS, Qian WJ: An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. J Proteome Res. 2009 Aug;8(8):3852-61. doi: 10.1021/pr900044c. [PubMed:19534553 ]
  6. Ek P, Pettersson G, Ek B, Gong F, Li JP, Zetterqvist O: Identification and characterization of a mammalian 14-kDa phosphohistidine phosphatase. Eur J Biochem. 2002 Oct;269(20):5016-23. [PubMed:12383260 ]
  7. Lai CH, Chiu JY, Lin W: Identification of the human crooked neck gene by comparative gene identification. Biochim Biophys Acta. 2001 Feb 16;1517(3):449-54. [PubMed:11342225 ]
  8. Ma R, Kanders E, Sundh UB, Geng M, Ek P, Zetterqvist O, Li JP: Mutational study of human phosphohistidine phosphatase: effect on enzymatic activity. Biochem Biophys Res Commun. 2005 Nov 25;337(3):887-91. Epub 2005 Sep 30. [PubMed:16219293 ]
  9. Busam RD, Thorsell AG, Flores A, Hammarstrom M, Persson C, Hallberg BM: First structure of a eukaryotic phosphohistidine phosphatase. J Biol Chem. 2006 Nov 10;281(45):33830-4. Epub 2006 Sep 21. [PubMed:16990267 ]
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