| Identification |
|---|
| HMDB Protein ID
| HMDBP11606 |
| Secondary Accession Numbers
| None |
| Name
| Aldo-keto reductase family 1 member B10 |
| Synonyms
|
- ARL-1
- Aldose reductase-like
- Aldose reductase-related protein
- Small intestine reductase
- ARP
- hARP
- SI reductase
|
| Gene Name
| AKR1B10 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
|
| Pathways
|
- Fructose and mannose metabolism
- Galactose metabolism
- Glycerolipid metabolism
- Pentose and glucuronate interconversions
- Pyruvate metabolism
|
| Reactions
|
| Glycerol + NAD → Glyceraldehyde + NADH + Hydrogen Ion |
details
|
| Glycerol + NADP → Glyceraldehyde + NADPH + Hydrogen Ion |
details
|
| beta-D-Galactose + NADH + Hydrogen Ion → Galactitol + NAD |
details
|
| beta-D-Galactose + NADPH + Hydrogen Ion → Galactitol + NADP |
details
|
| D-Xylitol + NADP → D-Xylose + NADPH + Hydrogen Ion |
details
|
| L-Arabitol + NAD → L-Arabinose + NADH + Hydrogen Ion |
details
|
| L-Arabitol + NADP → L-Arabinose + NADPH + Hydrogen Ion |
details
|
| Sorbitol + NADP → alpha-D-Glucose + NADPH + Hydrogen Ion |
details
|
| Lactaldehyde + NAD → Pyruvaldehyde + NADH + Hydrogen Ion |
details
|
| Propylene glycol + NADP → Lactaldehyde + NADPH + Hydrogen Ion |
details
|
|
| GO Classification
|
| Biological Process |
| cellular aldehyde metabolic process |
| daunorubicin metabolic process |
| digestion |
| doxorubicin metabolic process |
| farnesol catabolic process |
| steroid metabolic process |
| Cellular Component |
| lysosome |
| extracellular region |
| Molecular Function |
| aldo-keto reductase (NADP) activity |
| geranylgeranyl reductase activity |
| indanol dehydrogenase activity |
| retinal dehydrogenase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O60218 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:382 |
| References |
|---|
| General References
| Not Available |
