Canmetcon
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Identification
HMDB Protein ID HMDBP11606
Secondary Accession Numbers None
Name Aldo-keto reductase family 1 member B10
Synonyms
  1. ARL-1
  2. Aldose reductase-like
  3. Aldose reductase-related protein
  4. Small intestine reductase
  5. ARP
  6. hARP
  7. SI reductase
Gene Name AKR1B10
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
Pathways
  • Fructose and mannose metabolism
  • Galactose metabolism
  • Glycerolipid metabolism
  • Pentose and glucuronate interconversions
  • Pyruvate metabolism
Reactions
Glycerol + NAD → Glyceraldehyde + NADH + Hydrogen Ion details
Glycerol + NADP → Glyceraldehyde + NADPH + Hydrogen Ion details
Beta-D-Galactose + NADH + Hydrogen Ion → Galactitol + NAD details
Beta-D-Galactose + NADPH + Hydrogen Ion → Galactitol + NADP details
D-Xylitol + NADP → D-Xylose + NADPH + Hydrogen Ion details
L-Arabitol + NAD → L-Arabinose + NADH + Hydrogen Ion details
L-Arabitol + NADP → L-Arabinose + NADPH + Hydrogen Ion details
Sorbitol + NADP → Alpha-D-Glucose + NADPH + Hydrogen Ion details
Lactaldehyde + NAD → Pyruvaldehyde + NADH + Hydrogen Ion details
Propylene glycol + NADP → Lactaldehyde + NADPH + Hydrogen Ion details
GO Classification
Biological Process
cellular aldehyde metabolic process
daunorubicin metabolic process
digestion
doxorubicin metabolic process
farnesol catabolic process
steroid metabolic process
Cellular Component
lysosome
extracellular region
Molecular Function
aldo-keto reductase (NADP) activity
geranylgeranyl reductase activity
indanol dehydrogenase activity
retinal dehydrogenase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight Not Available
Theoretical pI Not Available
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O60218
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:382
References
General References Not Available