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Identification
HMDB Protein ID HMDBP11616
Secondary Accession Numbers None
Name Protein arginine N-methyltransferase 6
Synonyms
  1. Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6
  2. Histone-arginine N-methyltransferase PRMT6
Gene Name PRMT6
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). It thereby acts as a transcription corepressor of various genes such as HOXA2. Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to stimulate the polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).
Pathways Not Available
Reactions
S-Adenosylmethionine + arginine-[histone] → S-Adenosylhomocysteine + N(omega)-methyl-arginine-[histone] details
GO Classification
Biological Process
negative regulation of transcription, DNA-dependent
virus-host interaction
base-excision repair
transcription, DNA-dependent
Cellular Component
nucleus
Molecular Function
histone methyltransferase activity (H4-R3 specific)
histone binding
histone methyltransferase activity (H2A-R3 specific)
histone methyltransferase activity (H3-R2 specific)
protein-arginine omega-N asymmetric methyltransferase activity
protein-arginine omega-N monomethyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location 1
Locus 1p13.3
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 41937.22
Theoretical pI 5.436
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|227908867|ref|NP_060607.2| protein arginine N-methyltransferase 6 [Homo sapiens]
MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEM
IADRVRTDAY
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q96LA8
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:18241
References
General References Not Available