| Identification |
|---|
| HMDB Protein ID
| HMDBP11729 |
| Secondary Accession Numbers
| None |
| Name
| Elongation of very long chain fatty acids protein 6 |
| Synonyms
|
- 3-keto acyl-CoA synthase ELOVL6
- ELOVL fatty acid elongase 6
- Fatty acid elongase 2
- Fatty acyl-CoA elongase
- Long-chain fatty-acyl elongase
- Very-long-chain 3-oxoacyl-CoA synthase 6
- ELOVL FA elongase 6
- hELO2
|
| Gene Name
| ELOVL6 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16:0 acyl-CoAs.
|
| Pathways
|
- Biosynthesis of unsaturated fatty acids
- Fatty acid elongation
|
| Reactions
|
| A very-long-chain acyl-CoA + Malonyl-CoA → Coenzyme A + a very-long-chain 3-oxoacyl-CoA + CO(2) |
details
|
| Malonyl-CoA + Palmityl-CoA → 3-Oxooctadecanoyl-CoA + Coenzyme A + Carbon dioxide |
details
|
| Hexadecanoyl-[acp] + Malonyl-[acyl-carrier protein] → 3-Oxostearoyl-[acp] + Acyl-carrier protein + Carbon dioxide |
details
|
| Malonyl-CoA + Acyl-CoA → 3-Oxoacyl-CoA + Coenzyme A + Carbon dioxide |
details
|
|
| GO Classification
|
| Biological Process |
| fatty acid elongation, monounsaturated fatty acid |
| fatty acid elongation, saturated fatty acid |
| long-chain fatty acid biosynthetic process |
| long-chain fatty-acyl-CoA biosynthetic process |
| triglyceride biosynthetic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to endoplasmic reticulum membrane |
| Molecular Function |
| fatty acid elongase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q25 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 31375.81 |
| Theoretical pI
| 9.369 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>>gi|195539343|ref|NP_001124193.1| elongation of very long chain fatty acids protein 6 [Homo sapiens]
MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELR
KPLVLWSLTL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9H5J4 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:15829 |
| References |
|---|
| General References
| Not Available |
