| Identification |
|---|
| HMDB Protein ID
| HMDBP11733 |
| Secondary Accession Numbers
| None |
| Name
| TFIIH basal transcription factor complex helicase XPB subunit |
| Synonyms
|
- Basic transcription factor 2 89 kDa subunit
- DNA excision repair protein ERCC-3
- DNA repair protein complementing XP-B cells
- TFIIH basal transcription factor complex 89 kDa subunit
- Xeroderma pigmentosum group B-complementing protein
- BTF2 p89
- TFIIH 89 kDa subunit
- TFIIH p89
|
| Gene Name
| ERCC3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| ATP-dependent 3'-5' DNA helicase, component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.
|
| Pathways
|
- Basal transcription factors
- Nucleotide excision repair
|
| Reactions
|
| Adenosine triphosphate + Water → ADP + Phosphate |
details
|
|
| GO Classification
|
| Biological Process |
| transcription-coupled nucleotide-excision repair |
| response to oxidative stress |
| 7-methylguanosine mRNA capping |
| cell cycle checkpoint |
| protein localization |
| hair cell differentiation |
| nucleotide-excision repair, DNA damage removal |
| nucleotide-excision repair, DNA incision |
| termination of RNA polymerase I transcription |
| transcription elongation from RNA polymerase I promoter |
| transcription initiation from RNA polymerase I promoter |
| response to UV |
| DNA topological change |
| nucleotide-excision repair, DNA duplex unwinding |
| induction of apoptosis |
| virus-host interaction |
| viral reproduction |
| positive regulation of transcription from RNA polymerase II promoter |
| UV protection |
| response to hypoxia |
| positive regulation of viral transcription |
| transcription elongation from RNA polymerase II promoter |
| transcription initiation from RNA polymerase II promoter |
| Cellular Component |
| holo TFIIH complex |
| SSL2-core TFIIH complex |
| Molecular Function |
| ATP binding |
| transcription factor binding |
| ATP-dependent DNA helicase activity |
| peptide binding |
| 3'-5' DNA helicase activity |
| dATP binding |
| RNA polymerase II carboxy-terminal domain kinase activity |
| damaged DNA binding |
| ATPase activity |
| GTP binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q21 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 89276.985 |
| Theoretical pI
| 7.227 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>>gi|4557563|ref|NP_000113.1| TFIIH basal transcription factor complex helicase XPB subunit [Homo sapiens]
MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQVDESGTKVDEYGAKD
YRLQMPLKDD
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P19447 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:3435 |
| References |
|---|
| General References
| Not Available |
