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Identification
HMDB Protein ID HMDBP11927
Secondary Accession Numbers None
Name tRNA-splicing ligase RtcB homolog
Synonyms Not Available
Gene Name C22orf28
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs.
Pathways Not Available
Reactions
Adenosine triphosphate + (ribonucleotide)(n) + (ribonucleotide)(m) → Adenosine monophosphate + Pyrophosphate + (ribonucleotide)(n+m) details
GO Classification
Biological Process
substrate adhesion-dependent cell spreading
tRNA splicing, via endonucleolytic cleavage and ligation
cell-matrix adhesion
Cellular Component
cytoplasm
tRNA-splicing ligase complex
Molecular Function
RNA ligase (ATP) activity
metal ion binding
ATP binding
Cellular Location Not Available
Gene Properties
Chromosome Location 22
Locus 22q12
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 55209.95
Theoretical pI 7.218
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|7657015|ref|NP_055121.1| tRNA-splicing ligase RtcB homolog [Homo sapiens]
MSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVG
GFLPAMKQIG
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9Y3I0
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:26935
References
General References Not Available