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Identification
HMDB Protein ID HMDBP11929
Secondary Accession Numbers None
Name RuvB-like 1
Synonyms
  1. 49 kDa TATA box-binding protein-interacting protein
  2. 54 kDa erythrocyte cytosolic protein
  3. INO80 complex subunit H
  4. Nuclear matrix protein 238
  5. Pontin 52
  6. TIP49a
  7. TIP60-associated protein 54-alpha
  8. 49 kDa TBP-interacting protein
  9. ECP-54
  10. NMP 238
  11. TAP54-alpha
Gene Name RUVBL1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation. May be able to bind plasminogen at cell surface and enhance plasminogen activation.
Pathways
  • Wnt signaling pathway
Reactions
Adenosine triphosphate + Water → ADP + Phosphoric acid details
GO Classification
Biological Process
spermatogenesis
cell division
CENP-A containing nucleosome assembly at centromere
histone H2A acetylation
DNA repair
histone H4 acetylation
regulation of transcription from RNA polymerase II promoter
transcription, DNA-dependent
regulation of growth
mitosis
DNA recombination
Cellular Component
NuA4 histone acetyltransferase complex
Golgi apparatus
nuclear matrix
Ino80 complex
MLL1 complex
membrane
microtubule organizing center
Molecular Function
ATP binding
DNA helicase activity
Cellular Location Not Available
Gene Properties
Chromosome Location 3
Locus 3q21
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 50227.605
Theoretical pI 6.418
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|4506753|ref|NP_003698.1| ruvB-like 1 [Homo sapiens]
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAG
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9Y265
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:10474
References
General References Not Available