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Identification
HMDB Protein ID HMDBP12111
Secondary Accession Numbers None
Name Kit ligand
Synonyms
  1. Mast cell growth factor
  2. Stem cell factor
  3. c-Kit ligand
  4. MGF
  5. SCF
Gene Name KITLG
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Pathways
  • Hematopoietic cell lineage
  • MAPK signaling pathway
  • Melanogenesis
  • Phospholipase D signaling pathway
  • PI3K-Akt signaling pathway
  • Rap1 signaling pathway
  • Ras signaling pathway
Reactions Not Available
GO Classification
Biological Process
ectopic germ cell programmed cell death
extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of mast cell apoptotic process
neural crest cell migration
positive regulation of hematopoietic stem cell proliferation
positive regulation of leukocyte migration
positive regulation of mast cell proliferation
positive regulation of melanocyte differentiation
positive regulation of myeloid leukocyte differentiation
positive regulation of cell proliferation
cell adhesion
positive regulation of hematopoietic progenitor cell differentiation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein kinase B signaling cascade
male gonad development
MAPK cascade
positive regulation of Ras protein signal transduction
positive regulation of MAP kinase activity
embryonic hemopoiesis
ovarian follicle development
Cellular Component
cytoskeleton
cytoplasm
filopodium
plasma membrane
extracellular region
lamellipodium
extracellular space
integral to membrane
Molecular Function
stem cell factor receptor binding
growth factor activity
cytokine activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 273
Molecular Weight 30898.22
Theoretical pI 6.132
Pfam Domain Function
Signals
  • 1-25;
Transmembrane Regions
  • 215-237;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P21583
UniProtKB/Swiss-Prot Entry Name SCF_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  4. Martin FH, Suggs SV, Langley KE, Lu HS, Ting J, Okino KH, Morris CF, McNiece IK, Jacobsen FW, Mendiaz EA, et al.: Primary structure and functional expression of rat and human stem cell factor DNAs. Cell. 1990 Oct 5;63(1):203-11. [PubMed:2208279 ]
  5. Blair HC, Julian BA, Cao X, Jordan SE, Dong SS: Parathyroid hormone-regulated production of stem cell factor in human osteoblasts and osteoblast-like cells. Biochem Biophys Res Commun. 1999 Feb 24;255(3):778-84. [PubMed:10049787 ]
  6. Toyota M, Hinoda Y, Itoh F, Tsujisaki M, Imai K, Yachi A: Expression of two types of kit ligand mRNAs in human tumor cells. Int J Hematol. 1992 Jun;55(3):301-4. [PubMed:1379846 ]
  7. Anderson DM, Williams DE, Tushinski R, Gimpel S, Eisenman J, Cannizzaro LA, Aronson M, Croce CM, Huebner K, Cosman D, et al.: Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24. Cell Growth Differ. 1991 Aug;2(8):373-8. [PubMed:1724381 ]
  8. Lu HS, Clogston CL, Wypych J, Parker VP, Lee TD, Swiderek K, Baltera RF Jr, Patel AC, Chang DC, Brankow DW, et al.: Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells. Arch Biochem Biophys. 1992 Oct;298(1):150-8. doi: 10.1016/0003-9861(92)90106-7. [PubMed:1381905 ]
  9. Mauduit C, Hamamah S, Benahmed M: Stem cell factor/c-kit system in spermatogenesis. Hum Reprod Update. 1999 Sep-Oct;5(5):535-45. doi: 10.1093/humupd/5.5.535. [PubMed:10582791 ]
  10. Ronnstrand L: Signal transduction via the stem cell factor receptor/c-Kit. Cell Mol Life Sci. 2004 Oct;61(19-20):2535-48. doi: 10.1007/s00018-004-4189-6. [PubMed:15526160 ]