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Identification
HMDB Protein ID HMDBP12145
Secondary Accession Numbers None
Name Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Synonyms
  1. PIP5K1-beta
  2. PtdIns(4)P-5-kinase 1 beta
  3. Phosphatidylinositol 4-phosphate 5-kinase type I beta
  4. Protein STM-7
  5. Type I phosphatidylinositol 4-phosphate 5-kinase beta
  6. PIP5KIbeta
Gene Name PIP5K1B
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity).
Pathways
  • Choline metabolism in cancer
  • Endocytosis
  • Fc gamma R-mediated phagocytosis
  • Focal adhesion
  • Inositol phosphate metabolism
  • Phosphatidylinositol signaling system
  • Phospholipase D signaling pathway
  • Regulation of actin cytoskeleton
  • Yersinia infection
Reactions Not Available
GO Classification
Biological Process
phosphatidylinositol biosynthetic process
regulation of phosphatidylinositol 3-kinase cascade
Cellular Component
cytosol
plasma membrane
endomembrane system
uropod
Molecular Function
1-phosphatidylinositol-4-phosphate 5-kinase activity
ATP binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 502
Molecular Weight 61035.725
Theoretical pI 8.259
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O14986
UniProtKB/Swiss-Prot Entry Name PI51B_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H: Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15. [PubMed:19369195 ]
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  6. Pook MA, Carvajal JJ, Doudney K, Hillermann R, Chamberlain S: Exon-intron structure of a 2.7-kb transcript of the STM7 gene with phosphatidylinositol-4-phosphate 5-kinase activity. Genomics. 1997 May 15;42(1):170-2. [PubMed:9177790 ]
  7. Loijens JC, Anderson RA: Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. J Biol Chem. 1996 Dec 20;271(51):32937-43. [PubMed:8955136 ]
  8. Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [PubMed:23186163 ]