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Showing Protein Renin receptor (HMDBP12594)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12594
Secondary Accession Numbers None
Name Renin receptor
Synonyms
  1. ATPase H(+)-transporting lysosomal accessory protein 2
  2. ATPase H(+)-transporting lysosomal-interacting protein 2
  3. ER-localized type I transmembrane adapter
  4. Embryonic liver differentiation factor 10
  5. N14F
  6. Renin/prorenin receptor
  7. Vacuolar ATP synthase membrane sector-associated protein M8-9
  8. ATP6M8-9
  9. V-ATPase M8.9 subunit
Gene Name ATP6AP2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (v-ATPase) and the acidification of the endo-lysosomal system (PubMed:12045255, PubMed:29127204, PubMed:30374053, PubMed:32276428). May mediate renin-dependent cellular responses by activating ERK1 and ERK2 (PubMed:12045255). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (PubMed:12045255). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (By similarity).
Pathways
  • Renin-angiotensin system
Reactions Not Available
GO Classification
Biological Process
positive regulation of canonical Wnt receptor signaling pathway
lysosomal lumen acidification
neutrophil degranulation
angiotensin maturation
central nervous system maturation
eye pigmentation
head morphogenesis
positive regulation of transforming growth factor beta1 production
rostrocaudal neural tube patterning
regulation of MAPK cascade
positive regulation of Wnt receptor signaling pathway
Cellular Component
endoplasmic reticulum membrane
extracellular vesicular exosome
plasma membrane
postsynaptic membrane
cell body
autophagic vacuole membrane
dendritic spine membrane
ficolin-1-rich granule membrane
tertiary granule membrane
vacuolar proton-transporting V-type ATPase complex
lysosome
apical plasma membrane
external side of plasma membrane
endosome membrane
lysosomal membrane
axon
integral to membrane
Molecular Function
signaling receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 350
Molecular Weight 39007.605
Theoretical pI 6.1
Pfam Domain Function
Signals
  • 1-16;
Transmembrane Regions
  • 303-323;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O75787
UniProtKB/Swiss-Prot Entry Name RENR_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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