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Showing Protein DnaJ homolog subfamily A member 1 (HMDBP12598)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP12598
Secondary Accession Numbers None
Name DnaJ homolog subfamily A member 1
Synonyms
  1. DnaJ protein homolog 2
  2. HSDJ
  3. Heat shock 40 kDa protein 4
  4. Heat shock protein J2
  5. Human DnaJ protein 2
  6. HSJ-2
  7. hDj-2
Gene Name DNAJA1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).
Pathways
  • Protein processing in endoplasmic reticulum
Reactions Not Available
GO Classification
Biological Process
spermatogenesis
positive regulation of apoptotic process
negative regulation of protein ubiquitination
negative regulation of apoptotic process
response to heat
protein folding
negative regulation of establishment of protein localization to mitochondrion
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
protein localization to mitochondrion
regulation of protein transport
toxin transport
sperm motility
response to unfolded protein
DNA damage response, detection of DNA damage
negative regulation of JUN kinase activity
androgen receptor signaling pathway
Cellular Component
cytosol
microtubule cytoskeleton
mitochondrion
extracellular vesicular exosome
perinuclear region of cytoplasm
nucleus
cytoplasmic side of endoplasmic reticulum membrane
membrane
Molecular Function
unfolded protein binding
metal ion binding
ATP binding
ATPase activator activity
C3HC4-type RING finger domain binding
G protein-coupled receptor binding
Tat protein binding
ubiquitin protein ligase binding
chaperone binding
low-density lipoprotein particle receptor binding
Hsp70 protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 397
Molecular Weight 44867.99
Theoretical pI 7.078
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P31689
UniProtKB/Swiss-Prot Entry Name DNJA1_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  23. Rauch JN, Gestwicki JE: Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem. 2014 Jan 17;289(3):1402-14. doi: 10.1074/jbc.M113.521997. Epub 2013 Dec 5. [PubMed:24318877 ]
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