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Showing Protein N-acetyltransferase 8 (HMDBP12652)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12652
Secondary Accession Numbers None
Name N-acetyltransferase 8
Synonyms
  1. Acetyltransferase 2
  2. Camello-like protein 1
  3. Cysteinyl-conjugate N-acetyltransferase
  4. ATase2
  5. CCNAT
Gene Name NAT8
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).
Pathways
  • Glutathione metabolism
Reactions Not Available
GO Classification
Biological Process
negative regulation of apoptotic process
response to drug
glutathione metabolic process
positive regulation of gene expression
amyloid fibril formation
amyloid-beta metabolic process
peptidyl-lysine N6-acetylation
Cellular Component
endoplasmic reticulum membrane
endoplasmic reticulum
endoplasmic reticulum-Golgi intermediate compartment membrane
endoplasmic reticulum-Golgi intermediate compartment
integral to membrane
Molecular Function
N-acetyltransferase activity
lysine N-acetyltransferase activity
cysteine-S-conjugate N-acetyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 227
Molecular Weight 25618.83
Theoretical pI 8.904
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 43-63;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9UHE5
UniProtKB/Swiss-Prot Entry Name NAT8_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Ozaki K, Fujiwara T, Nakamura Y, Takahashi E: Isolation and mapping of a novel human kidney- and liver-specific gene homologous to the bacterial acetyltransferases. J Hum Genet. 1998;43(4):255-8. doi: 10.1007/s100380050084. [PubMed:9852678 ]
  3. Popsueva AE, Luchinskaya NN, Ludwig AV, Zinovjeva OY, Poteryaev DA, Feigelman MM, Ponomarev MB, Berekelya L, Belyavsky AV: Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. Dev Biol. 2001 Jun 15;234(2):483-96. doi: 10.1006/dbio.2001.0261. [PubMed:11397015 ]
  4. Ko MH, Puglielli L: Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. J Biol Chem. 2009 Jan 23;284(4):2482-92. doi: 10.1074/jbc.M804901200. Epub 2008 Nov 14. [PubMed:19011241 ]
  5. Veiga-da-Cunha M, Tyteca D, Stroobant V, Courtoy PJ, Opperdoes FR, Van Schaftingen E: Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids. J Biol Chem. 2010 Jun 11;285(24):18888-98. doi: 10.1074/jbc.M110.110924. Epub 2010 Apr 13. [PubMed:20392701 ]
  6. Ding Y, Ko MH, Pehar M, Kotch F, Peters NR, Luo Y, Salamat SM, Puglielli L: Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation. J Biol Chem. 2012 Mar 9;287(11):8424-33. doi: 10.1074/jbc.M111.310136. Epub 2012 Jan 20. [PubMed:22267734 ]