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Showing Protein C-type lectin domain family 6 member A (HMDBP12810)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12810
Secondary Accession Numbers None
Name C-type lectin domain family 6 member A
Synonyms
  1. C-type lectin superfamily member 10
  2. Dendritic cell-associated C-type lectin 2
  3. DC-associated C-type lectin 2
  4. Dectin-2
Gene Name CLEC6A
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:23911656, PubMed:28652405). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (By similarity). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity).
Pathways
  • C-type lectin receptor signaling pathway
Reactions Not Available
GO Classification
Biological Process
positive regulation of cytokine production
stimulatory C-type lectin receptor signaling pathway
innate immune response
positive regulation of I-kappaB kinase/NF-kappaB cascade
adaptive immune response
defense response to fungus
Cellular Component
plasma membrane
integral to membrane
Molecular Function
carbohydrate binding
mannose binding
calcium ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 209
Molecular Weight 23997.94
Theoretical pI 6.261
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 21-41;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q6EIG7
UniProtKB/Swiss-Prot Entry Name CLC6A_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Flornes LM, Bryceson YT, Spurkland A, Lorentzen JC, Dissen E, Fossum S: Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. Immunogenetics. 2004 Oct;56(7):506-17. doi: 10.1007/s00251-004-0714-x. Epub 2004 Sep 11. [PubMed:15368084 ]
  4. Kanazawa N, Tashiro K, Inaba K, Lutz MB, Miyachi Y: Molecular cloning of human dectin-2. J Invest Dermatol. 2004 Jun;122(6):1522-4. doi: 10.1111/j.0022-202X.2004.22602.x. [PubMed:15175046 ]
  5. Gavino AC, Chung JS, Sato K, Ariizumi K, Cruz PD Jr: Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2. Exp Dermatol. 2005 Apr;14(4):281-8. doi: 10.1111/j.0906-6705.2005.00312.x. [PubMed:15810886 ]
  6. Zhu LL, Zhao XQ, Jiang C, You Y, Chen XP, Jiang YY, Jia XM, Lin X: C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. Immunity. 2013 Aug 22;39(2):324-34. doi: 10.1016/j.immuni.2013.05.017. Epub 2013 Aug 1. [PubMed:23911656 ]
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