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Identification
HMDB Protein ID HMDBP13410
Secondary Accession Numbers None
Name Rho GTPase-activating protein 22
Synonyms
  1. Rho-type GTPase-activating protein 22
Gene Name ARHGAP22
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
regulation of postsynapse organization
signal transduction
activation of GTPase activity
regulation of small GTPase mediated signal transduction
angiogenesis
cell differentiation
Cellular Component
cytosol
focal adhesion
nucleus
glutamatergic synapse
Molecular Function
GTPase activator activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 698
Molecular Weight 76778.155
Theoretical pI 8.148
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q7Z5H3
UniProtKB/Swiss-Prot Entry Name RHG22_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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