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Identification
HMDB Protein ID HMDBP13411
Secondary Accession Numbers None
Name Endothelial transcription factor GATA-2
Synonyms
  1. GATA-binding protein 2
Gene Name GATA2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
negative regulation of neural precursor cell proliferation
vascular wound healing
positive regulation of cell migration involved in sprouting angiogenesis
elevation of cytosolic calcium ion concentration
definitive hemopoiesis
somatic stem cell maintenance
homeostasis of number of cells within a tissue
negative regulation of fat cell differentiation
phagocytosis
positive regulation of neuron differentiation
neuron migration
response to lipid
urogenital system development
negative regulation of endothelial cell apoptotic process
positive regulation of phagocytosis
positive regulation of pri-miRNA transcription by RNA polymerase II
positive regulation of blood vessel endothelial cell migration
positive regulation of angiogenesis
cell differentiation in hindbrain
cell fate determination
regulation of transcription from RNA polymerase II promoter
positive regulation of mast cell degranulation
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
cell maturation
commitment of neuronal cell to specific neuron type in forebrain
embryonic placenta development
eosinophil fate commitment
GABAergic neuron differentiation
negative regulation of fat cell proliferation
negative regulation of macrophage differentiation
blood coagulation
positive regulation of megakaryocyte differentiation
positive regulation of phagocytosis, engulfment
regulation of forebrain neuron differentiation
regulation of hematopoietic stem cell differentiation
regulation of histone acetylation
regulation of primitive erythrocyte differentiation
semicircular canal development
ventral spinal cord interneuron differentiation
inner ear morphogenesis
negative regulation of transcription from RNA polymerase II promoter
cochlea development
positive regulation of transcription from RNA polymerase II promoter
cell fate commitment
negative regulation of Notch signaling pathway
positive regulation of erythrocyte differentiation
pituitary gland development
positive regulation of gene expression
negative regulation of gene expression
central nervous system neuron development
Cellular Component
cytoplasm
nucleus
nucleoplasm
transcription factor complex
Molecular Function
sequence-specific DNA binding transcription factor activity
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription factor binding
zinc ion binding
chromatin binding
DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II core promoter proximal region sequence-specific DNA binding
C2H2 zinc finger domain binding
sequence-specific double-stranded DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 480
Molecular Weight 50499.505
Theoretical pI 9.301
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P23769
UniProtKB/Swiss-Prot Entry Name GATA2_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  4. Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [PubMed:23186163 ]
  5. Hendriks IA, Lyon D, Young C, Jensen LJ, Vertegaal AC, Nielsen ML: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat Struct Mol Biol. 2017 Mar;24(3):325-336. doi: 10.1038/nsmb.3366. Epub 2017 Jan 23. [PubMed:28112733 ]
  6. Lee ME, Temizer DH, Clifford JA, Quertermous T: Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells. J Biol Chem. 1991 Aug 25;266(24):16188-92. [PubMed:1714909 ]
  7. Dorfman DM, Wilson DB, Bruns GA, Orkin SH: Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells. J Biol Chem. 1992 Jan 15;267(2):1279-85. [PubMed:1370462 ]
  8. Seo WY, Jeong BC, Yu EJ, Kim HJ, Kim SH, Lim JE, Kwon GY, Lee HM, Kim JH: CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2. Nucleic Acids Res. 2013 Oct;41(18):8526-36. doi: 10.1093/nar/gkt644. Epub 2013 Jul 25. [PubMed:23887938 ]
  9. Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87. doi: 10.1074/mcp.O113.027870. Epub 2013 Oct 15. [PubMed:24129315 ]
  10. Hsu AP, Sampaio EP, Khan J, Calvo KR, Lemieux JE, Patel SY, Frucht DM, Vinh DC, Auth RD, Freeman AF, Olivier KN, Uzel G, Zerbe CS, Spalding C, Pittaluga S, Raffeld M, Kuhns DB, Ding L, Paulson ML, Marciano BE, Gea-Banacloche JC, Orange JS, Cuellar-Rodriguez J, Hickstein DD, Holland SM: Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome. Blood. 2011 Sep 8;118(10):2653-5. doi: 10.1182/blood-2011-05-356352. Epub 2011 Jun 13. [PubMed:21670465 ]
  11. Ostergaard P, Simpson MA, Connell FC, Steward CG, Brice G, Woollard WJ, Dafou D, Kilo T, Smithson S, Lunt P, Murday VA, Hodgson S, Keenan R, Pilz DT, Martinez-Corral I, Makinen T, Mortimer PS, Jeffery S, Trembath RC, Mansour S: Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome). Nat Genet. 2011 Sep 4;43(10):929-31. doi: 10.1038/ng.923. [PubMed:21892158 ]
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