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Showing Protein Growth factor receptor-bound protein 2 (HMDBP13428)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13428
Secondary Accession Numbers None
Name Growth factor receptor-bound protein 2
Synonyms
  1. Adapter protein GRB2
  2. SH2/SH3 adapter GRB2
Gene Name GRB2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Pathways
  • Acute myeloid leukemia
  • Alcoholism
  • B cell receptor signaling pathway
  • Breast cancer
  • Chemical carcinogenesis - reactive oxygen species
  • Chemical carcinogenesis - receptor activation
  • Chemokine signaling pathway
  • Choline metabolism in cancer
  • Chronic myeloid leukemia
  • Colorectal cancer
  • EGFR tyrosine kinase inhibitor resistance
  • Endocrine resistance
  • Endometrial cancer
  • ErbB signaling pathway
  • Estrogen signaling pathway
  • Fc epsilon RI signaling pathway
  • Focal adhesion
  • FoxO signaling pathway
  • Gap junction
  • Gastric cancer
  • Glioma
  • GnRH signaling pathway
  • Growth hormone synthesis, secretion and action
  • Hepatitis B
  • Hepatitis C
  • Hepatocellular carcinoma
  • Human cytomegalovirus infection
  • Human papillomavirus infection
  • Insulin signaling pathway
  • JAK-STAT signaling pathway
  • MAPK signaling pathway
  • MicroRNAs in cancer
  • mTOR signaling pathway
  • Natural killer cell mediated cytotoxicity
  • Neurotrophin signaling pathway
  • Non-small cell lung cancer
  • Osteoclast differentiation
  • Phospholipase D signaling pathway
  • PI3K-Akt signaling pathway
  • Prolactin signaling pathway
  • Prostate cancer
  • Proteoglycans in cancer
  • Ras signaling pathway
  • Relaxin signaling pathway
  • Renal cell carcinoma
  • Signaling pathways regulating pluripotency of stem cells
  • T cell receptor signaling pathway
  • Thermogenesis
  • Viral carcinogenesis
Reactions Not Available
GO Classification
Biological Process
positive regulation of reactive oxygen species metabolic process
receptor internalization
insulin receptor signaling pathway
cell differentiation
actin cytoskeleton reorganization
regulation of MAPK cascade
aging
Ras protein signal transduction
anatomical structure formation involved in morphogenesis
branching involved in labyrinthine layer morphogenesis
positive regulation of actin filament polymerization
signal transduction in response to DNA damage
cellular response to ionizing radiation
epidermal growth factor receptor signaling pathway
Cellular Component
cytosol
protein-containing complex
cytoplasm
nucleolus
plasma membrane
Golgi apparatus
nucleus
cell-cell junction
nucleoplasm
signalosome
vesicle membrane
Grb2-EGFR complex
membrane
endosome
Molecular Function
protein kinase binding
protein-containing complex binding
epidermal growth factor receptor binding
SH3 domain binding
phosphotyrosine binding
protein domain specific binding
enzyme binding
ephrin receptor binding
insulin receptor substrate binding
neurotrophin TRKA receptor binding
phosphoprotein binding
protein-macromolecule adaptor activity
identical protein binding
protein phosphatase binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 217
Molecular Weight 25238.27
Theoretical pI 6.31
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q60631
UniProtKB/Swiss-Prot Entry Name GRB2_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  12. Thommes K, Lennartsson J, Carlberg M, Ronnstrand L: Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor. Biochem J. 1999 Jul 1;341 ( Pt 1):211-6. [PubMed:10377264 ]
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