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Identification
HMDB Protein ID HMDBP13485
Secondary Accession Numbers None
Name Diphthine methyltransferase
Synonyms
  1. Diphthamide biosynthesis protein 7
  2. WD repeat-containing protein 85
Gene Name DPH7
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).
Pathways
  • peptidyl-diphthamide biosynthesis
Reactions Not Available
GO Classification
Biological Process
peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Molecular Function
diphthine methylesterase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 452
Molecular Weight 50574.915
Theoretical pI 6.589
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9BTV6
UniProtKB/Swiss-Prot Entry Name DPH7_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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