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Identification
HMDB Protein ID HMDBP13636
Secondary Accession Numbers None
Name Neuropeptide Y receptor type 2
Synonyms
  1. NPY2-R
  2. NPY-Y2 receptor
  3. Y2 receptor
Gene Name NPY2R
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
Pathways
  • Neuroactive ligand-receptor interaction
Reactions Not Available
GO Classification
Biological Process
locomotory behavior
elevation of cytosolic calcium ion concentration
nitric oxide mediated signal transduction
negative regulation of excitatory postsynaptic membrane potential
G-protein coupled receptor signaling pathway
outflow tract morphogenesis
negative regulation of synaptic transmission, glutamatergic
positive regulation of cell-substrate adhesion
secretion
behavioral fear response
cardiac left ventricle morphogenesis
negative regulation of feeding behavior
negative regulation of nervous system process
aging
negative regulation of secretion
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of dopamine secretion
positive regulation of peptide secretion
regulation of sensory perception of pain
negative regulation of cAMP-mediated signaling
positive regulation of smooth muscle contraction
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
Cellular Component
cilium
plasma membrane
non-motile cilium
integral to plasma membrane
Molecular Function
calcium channel regulator activity
signaling receptor activity
peptide YY receptor activity
neuropeptide Y receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 381
Molecular Weight 42730.69
Theoretical pI 7.232
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 52-72;87-107;125-145;166-186;217-237;269-289;305-325;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P49146
UniProtKB/Swiss-Prot Entry Name NPY2R_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [PubMed:15815621 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W: Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4661-5. [PubMed:8643460 ]
  4. Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL: Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J Biol Chem. 1995 Nov 10;270(45):26758-61. doi: 10.1074/jbc.270.45.26758. [PubMed:7592910 ]
  5. Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA: Expression cloning of a human brain neuropeptide Y Y2 receptor. Mol Pharmacol. 1996 Feb;49(2):224-8. [PubMed:8632753 ]
  6. Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R: Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. J Biol Chem. 1995 Sep 29;270(39):22661-4. doi: 10.1074/jbc.270.39.22661. [PubMed:7559383 ]
  7. Ammar DA, Eadie DM, Wong DJ, Ma YY, Kolakowski LF Jr, Yang-Feng TL, Thompson DA: Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene. Genomics. 1996 Dec 15;38(3):392-8. doi: 10.1006/geno.1996.0642. [PubMed:8975716 ]